Conserved Protein Domain Family
T3SS_needle_reg
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pfam09025: T3SS_needle_reg 
YopR, type III needle-polymerization regulator
The YopR core domain, predominantly found in the Gammaproteobacteria virulence factor YopR, is composed of five alpha-helices, four of which are arranged in an antiparallel bundle. Little is known about this domain, though it may contribute to the virulence of the protein YopR. YopR controls the selective access of early (YscF, YscI and YscP) substrates to the type III secretion machines of yersiniae and other Gammaproteobacteriae. YopR is a mobile regulatory component thought to function as a checkpoints probing the completion of discrete intermediary stages in the assembly of the type III injection pathway. The location of secreted YopR (into the medium) is directly controlling the secretion of YscF, the polymerized needle protein pfam09392, thereby impacting the assembly of type III machines.
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Statistics
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PSSM-Id: 286158
Aligned: 3 rows
Threshold Bit Score: 191.385
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7N0U6  39 QQMLKErqqrwlqgepLENVLGDLDPATQRKVIWQWYQAlssdKQPSQRAQLQAkLIAPVQERLWSQFGGLAGNIKPPLD 118 Photorhabdus laumondi...
P68590  28 SELKTQ----------LENKLKSESAEKTREVLWQQYYA----SNPPDHAVLEV-LATPVREALLARFGQHQGSVVPAID 92  Yersinia pestis
Q87P26  68 KEAETVskqs--vlssLKDVIS--DPQTQKEALWYAFHQak-sAKGTDDAVPE--LLSVLKQELLGDFAG-QLMAEPPTD 139 Vibrio parahaemolyticus

Q7N0U6 119 MPELRKIVREFAPTGRQQETVLLEVLGEIKP------IPgneYLSDLIRQELKTLIPRNGMVDNLIRNSHKPDLE 187 Photorhabdus laumondii sub...
P68590  93 LPELRSVLQQFDSFGKRWEAILLQVLEGIKPnesqvgLP---YLSELINKELMILLPSNSIVDSLLHNSHQIDMD 164 Yersinia pestis
Q87P26 140 RAALKAMLAQSFPLGAQKEQALWHCWAELKS------LPemtSTVDLVREELSFVIQKNAMVKNIMTHSHKLDLS 208 Vibrio parahaemolyticus
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