2KRG


Conserved Protein Domain Family
EBP50_C

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pfam09007: EBP50_C 
EBP50, C-terminal
This C terminal domain allows interaction of EBP50 with FERM (four-point one ERM) domains, resulting in the activation of Ezrin-radixin-moesin (ERM), with subsequent cytoskeletal modulation and cellular growth control. It includes a disordered section between two reasonably well conserved hydrophobic regions.
Statistics
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PSSM-Id: 401087
View PSSM: pfam09007
Aligned: 28 rows
Threshold Bit Score: 100.209
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2KRG_A        93 TDEFFKKCRVIPSQEHLNG------PLP----VPFTNGE-IQKENSREALAEAAles--prpALVRSAS--SDTSEELNS 157
7_pfamImport   1 TDQLFHRLGMRPTSSQVKGq-------------------vYQPVMKITVTNSPTtstspkslSDGSSASv-SSRSSITQS 60 
2_pfamImport   1 TDDFFRRCQVIPSEAHLSG------PLP----EPVVNGEvEEKMNGKVTKESG---------PTNPTPEetSIPTTPTAL 61 
POI32349     201 ADEFFKKCRVVPSEAHLAG------PLP----EPIANGD-IEKENGGEPRLNSVserp-pspALATSPEg-SETHSEPDM 267 Chinese bamboo-...
XP_007668079  37 TDEFFKKCRVVPSQEHLSG------ALP----EPVANGE-VEKESSREVHLAPVpes--prpAIARS-Tl-SVTSEEVNS 101 platypus
XP_023358263 245 TDEFFKKCKVIPSQEHLSG------PLP----EPVANGE-VEKESSG-TWTEEVces--pkpASSRS-Tl-SETSDEMDS 308 Tasmanian devil
XP_001369788 243 TDEFFKKCKVIPSQEHLNG------PLP----EPVANGE-VEKESSSATWSEAAcec--pkpASSRS-Tl-SDASDEVDS 307 gray short-tail...
XP_010719995  98 ADEFFKKCRVVPSEAHLAG------PLP----EPIANGD-IEKENGGEPRLNSVser--ppsPALATSPegTETHSEPDA 164 turkey
XP_027327270 222 TDEFFKKCKVVPSEAHLAGplpepvANGdiekEN-----------SEELRSSSAsers-pspVLATSPDg-SETRSEPGV 288 mallard
NP_001006751 199 ADSYFKECNVVPGKQHLTG------PLP----EKLANGG-LEKLNNSEEQIHPEsplsspepAPDMVTPk-LEAQK---- 262 tropical clawed...
2KRG_A       158 QDSPPKQDSTAPSST-------------------------SSSDP--ILDFNISLAMAKERAHQKRSSKRAPQMDWSKKN 210
7_pfamImport  61 ELSSSDMSFQVHDEDdg---------------------rvLDPFMdsGLRFSPTAAEAKLKALAGRNKKRAPAMDWNKKH 119
2_pfamImport  62 TREVKKKIPESKLLGlfvppppmgtqdkllllipktqeeeKDDASdpGLNLNISLAAAKERAHQKR---KAPQMDWSKKN 138
POI32349     268 QEGDKR-----------------------------------SSAPssLLDLDIPLAVAKERAHQKRTSKRAPQMDWSKKN 312 Chinese bamboo-...
XP_007668079 102 QESPKKADPTP------------------------------TPGSdpVPDFAISLAAAKERAHQKRSSKRAPAMDWSKKN 151 platypus
XP_023358263 309 QD---KQDSTPPSST--------------------------SSSSdpILDFNISLAVAKERAHQKRSSKRAPQMDWSKKN 359 Tasmanian devil
XP_001369788 308 QDSPKK-DSTPPSST--------------------------SSSSdpILDFNISLAVAKERAHQKRSSKRAPQMDWSKKN 360 gray short-tail...
XP_010719995 165 QEGDKR-----------------------------------SSAPssLLDLDIPLAVAKERAHQKRTSKRAPQMDWSKKN 209 turkey
XP_027327270 289 PEGDKR-----------------------------------SSASgsLLDLDIPLAVAKERAHQKRTSKRAPQMDWSKKN 333 mallard
NP_001006751 263 --DSSENTPAPASDA--------------------------TSPTepVLDLNMSLALAKERAHQKRSQKKAPSMDWSKKK 314 tropical clawed...
2KRG_A       211 ELFSNL 216
7_pfamImport 120 ETFSNF 125
2_pfamImport 139 EVFSNL 144
POI32349     313 ELFSNL 318 Chinese bamboo-partridge
XP_007668079 152 ELFSNL 157 platypus
XP_023358263 360 ELFSNL 365 Tasmanian devil
XP_001369788 361 ELFSNL 366 gray short-tailed opossum
XP_010719995 210 ELFSNL 215 turkey
XP_027327270 334 ELFSNL 339 mallard
NP_001006751 315 EVFSSL 320 tropical clawed frog
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