Conserved Protein Domain Family
Cytotoxic

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pfam09000: Cytotoxic 
Cytotoxic
The cytotoxic domain confers cytotoxic activity to proteins, enabling the formation of nucleolytic breaks in 16S ribosomal RNA. The structure of the domain reveals a highly twisted central beta-sheet elaborated with a short N-terminal alpha-helix.
Statistics
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PSSM-Id: 401084
View PSSM: pfam09000
Aligned: 7 rows
Threshold Bit Score: 119.91
Threshold Setting Gi: 428271158
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_015696195            433 HPAPETeeISGLSGLRQSKKKTPKQSGGGLRERWADSKGrRIYEWDSQHGELEEYRASDGeHLGSVDHKTGQQLKPAVKG 512  Rah...
jgi:Srot_2950           352 IPAPKT--LEGFPDAKPDKKKTPVRGGGSLRPRWKDKKG-KIYEWDSKKGTVEKYSKDGKtHEGEFDPKTGEQVGKPVPG 428  Seg...
jgi:Sta7437_3601          4 IPPPKN--LSAFPEAKQVKPKTPIAGGG-LRKRWKDKD--YIYEWDSYHGRVEKYDKRGN-HLGEFDPNTGEQTKPADSN 77   Sta...
jgi:HSM_1646            349 IPAPRKdeITGITGLTEVKRKTSIQGGGKLRNRWKDREG-YIYEWDSQHGTLEKYNHKGK-HLGEFNYKTGKQTKSADPT 426  His...
SLUandSVAtrep:TPE_1597  133 iPAPDS--IPDIPDAKIAKRKTLVQKGGALRKRWKDDKG-NIYEWDSLHGELEKYNKRGI-HQGVVDPNTGEQIETPKND 208  Tre...
Q7NU32                 3739 VPRPDVsdITGVDGLKRDRPKTPVQGGGGLRPRWKDEMG-NIYEWDSYHGELEKYNKNGK-HLGAFDYRTGQQIKPPEPG 3816 Chr...
CBJ91313                490 HPAPETedIKGLGDLEEAAAKTPKQGGGGKRARWFGDKRrKIYEWDSQHGELEGYRASDGkHLGSFDPKTGRQLKSADPK 569  Xen...
WP_015696195            513 RNIK 516  Rahnella aquatilis
jgi:Srot_2950           429 RTVE 432  Segniliparus rotundus DSM 44985
jgi:Sta7437_3601         78 RKIK 81   Stanieria cyanosphaera PCC 7437
jgi:HSM_1646            427 RRIE 430  Histophilus somni 2336
SLUandSVAtrep:TPE_1597  209 RKVe 212  Treponema pedis str. T A4
Q7NU32                 3817 RKVE 3820 Chromobacterium violaceum
CBJ91313                570 RNIK 573  Xenorhabdus nematophila ATCC 19061
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