3FLO,5EXR


Conserved Protein Domain Family
zf-DNA_Pol

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pfam08996: zf-DNA_Pol 
DNA Polymerase alpha zinc finger
The DNA Polymerase alpha zinc finger domain adopts an alpha-helix-like structure, followed by three turns, all of which involve proline. The resulting motif is a helix-turn-helix motif, in contrast to other zinc finger domains, which show anti-parallel sheet and helix conformation. Zinc binding occurs due to the presence of four cysteine residues positioned to bind the metal centre in a tetrahedral coordination geometry. Function of this domain is uncertain: it has been proposed that the zinc finger motif may be an essential part of the DNA binding domain.
Statistics
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PSSM-Id: 401082
View PSSM: pfam08996
Aligned: 132 rows
Threshold Bit Score: 132.33
Threshold Setting Gi: 281203060
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FLO_B          9 ITD-VERFKDTVTLELSCPS--CDKRFPFGGIVSSN-----------------YYRVSYNGLQCKhCEQLF-----TPLQ 63  
EFO86903     1272 ctwqQESYELCEGVIVICPYaeCGETNVIRETFDSTt---------------dPTCPRLLLSGCSkCDKSWe---sSEHQ 1333 Caenorhabditi...
CAP32014     1272 ctwqQENYELCEGVVVVCPHpeCGHSNVIRETFDCVt---------------dPTSPRFLIAGCSqCNGTWe---sSEHQ 1333 Caenorhabditi...
Q9NAH1       1228 cawhQENYDLCEGIHVICPLdgCGHSNVIRETFDCVt---------------dASSPRLLFSGCAqCQGSWd---lQEHQ 1289 Caenorhabditi...
NP_001266164 1352 vaDdEERFRGCEPLTLTCPS--CSCSFECAPIFSSIcssirqnp--adlqvgeSASKVWERFSCPkCPEESeg-niSSAL 1426 tomato
XP_009393418 1338 IIDdEERYRGCEPLRLSCPS--CSSTFDCPPV-SSLlstmhkesqsdsqaedlTGANFWKRMRCPrCPDSIdgceiSSAM 1414 wild Malaysia...
ERN08693     1340 tADdEDRYRGCEPLWISCPS--CSASFECPTV-SSLitalasqkktesqtqeePGGNFWLRLRCSrCPDEGdgsriSPAM 1416 Amborella tri...
RVW55391     1404 lsAdEERYRGCEHLILSCPS--CFGTFDCPTLFNSVhtsiteks--tqvqveeS-NNFWQRLRCPkCPEEGdvgrmSPAL 1478 wine grape
XP_006573639 1336 vaDdEERYRGCEPLVLSCPS--CSGTFDCPPVFKSIcllgserqrptsvapeeAEYNFWRKLCCPkCPDVKi----SPVM 1409 soybean
XP_002523609 1316 aVNdEERYRSCEPLLLSCPS--CSGTFECPAVFGSIctsisanp--tklqveeSVSNFWCRMRCPkCPEEGdtgriSPAM 1391 castor bean
3FLO_B         64 L--TSQIEHSIRAHISLYYAGWLQCDDSTCGIVTR---QVSVFGKR----CLNDG-C-TGVMRYKYSDKQLYNQLLYFDS 132 
EFO86903     1334 AviFNQIDRQLGEFVSRHHAAAFRCDEPTCEFKTR---VQTMKWCRegleCVR---CsTGVLRREYTSKQLFDQQMFFRQ 1407 Caenorhabditi...
CAP32014     1334 AviSNQIDCQLGEFVARHHIAAYKCDEPTCEFKTR---VQTMKWCRegleCIR---CsTGVLRREYTSKQLFDQQMFFRQ 1407 Caenorhabditi...
Q9NAH1       1290 AviGNQVDRQMSEFVARHHLAAFKCDEPTCEFKTR---VQTMKWCRegleCIR---CsTGVLRREYTSKQLFDQQMFFRT 1363 Caenorhabditi...
NP_001266164 1427 I--ANQVKRQVEGFISTYYKGVMMCDDETCNYTTRslnLRVIGDSErgtvCPNYPrC-NGHLLRQYTEADLYKQLAYFCF 1503 tomato
XP_009393418 1415 L--ANQVKRQAESFICTYYKGLMMCDDEICKYTTRslnLRVIGDSErgtvCPNYPrC-NGHLIRQYTEADLYKQLSYFCH 1491 wild Malaysia...
ERN08693     1417 I--ANQVKRQAEKFISKYYDGLMMCDDEMCKHTTRtlnLRVIGESErgtvCPNFPrC-NGHLIKEYTEAELYRQLSYYCH 1493 Amborella tri...
RVW55391     1479 I--ANQVKRQADGFISMYYKGSMMCDDETCKHTTNslnLRVIGDSErgtvCPNYPrC-NGRLVRKYTEADLYKQLSYFCH 1555 wine grape
XP_006573639 1410 I--ANQVKRQAERFILMYYRGLLVCDDETCKHTTRsisLRLVGDSErgtvCPNYPrC-NGRLVRKYTEADLYKQLSYFCH 1486 soybean
XP_002523609 1392 L--ANQVKRQAEGFVSMYYKGLMTCDDETCKHITRslnLRLIGDSErgtvCPNYPrC-NGRLVRKYTEAELYKQLSFYCY 1468 castor bean
3FLO_B        133 LFDCEKNKKQELKPiylpddldypkeQ------------------LTESSIKALTEQNRELMETGRSVV-QKYLNDCGRR 193 
EFO86903     1408 IFDVETAIRKLSDS------------QkskifelimgfyifsfpgASENSDRQRFTACRIDSMEIVNRItKKYLERNSYN 1475 Caenorhabditi...
CAP32014     1408 IFDVDAALRKMSDS------------Qk----------------rAAENRDRQQFNACRIDSMDIVNRInEKYLERNSYN 1459 Caenorhabditi...
Q9NAH1       1364 ILDVDAAVRKLSDA------------Q------------------KKAAKVRVEYNGCKIDSMMLADRInEKYLEKNAYN 1413 Caenorhabditi...
NP_001266164 1504 VLDTVRCIEKV--E------------S------------------NMRLQVEKELVRIRPVVEAAASTV-EKFRDRCAYS 1550 tomato
XP_009393418 1492 VLDATRFLEKL--E------------Q------------------KVTAPIEKELNMIRPVVSPAASVI-QKIRDRCSYG 1538 wild Malaysia...
ERN08693     1494 VLDSARFIGKL--E------------Y------------------SMRIAIEKHLASIRPLVEPASSTI-QRIRESCAYG 1540 Amborella tri...
RVW55391     1556 VLDTVRCIEKM--E------------V------------------STRIPIEKELARIRPLVNLAASTT-QKIRDRCAYG 1602 wine grape
XP_006573639 1487 VFDTVSCIEKM--E------------A------------------KSRIPIEKELIKIRAVIKSAASTA-QEIRDRCAFG 1533 soybean
XP_002523609 1469 LLDTVRCMEKM--D------------A------------------GTRISLEKKITKIRPMVDLAVSTV-QKIRDRCAYG 1515 castor bean
3FLO_B        194 YVDMTSIF 201 
EFO86903     1476 RVDLSYIF 1483 Caenorhabditis remanei
CAP32014     1460 RVDLSYIF 1467 Caenorhabditis briggsae
Q9NAH1       1414 RVDLSYIF 1421 Caenorhabditis elegans
NP_001266164 1551 WVQLKDLi 1558 tomato
XP_009393418 1539 WVQLDDLc 1546 wild Malaysian banana
ERN08693     1541 WVRLKDLc 1548 Amborella trichopoda
RVW55391     1603 WVQLDDLt 1610 wine grape
XP_006573639 1534 WVKLENLv 1541 soybean
XP_002523609 1516 WVQLSDLs 1523 castor bean
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