Conserved Protein Domain Family
MTCP1

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pfam08991: MTCP1 
Mature-T-Cell Proliferation I type
Members of this family adopt a coiled coil structure, with two antiparallel alpha-helices that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows a cysteine motif, required for the stabilisation of the coiled-coil-like structure. Additional inter-helix hydrophobic contacts impart stability to this scaffold. The precise function of this eukaryotic domain is, as yet, unknown. MTCP1 is found in mitochondria. Mature-T-Cell Proliferation) is the first gene unequivocally identified in the group of uncommon leukemias with a mature phenotype.
Statistics
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PSSM-Id: 401078
View PSSM: pfam08991
Aligned: 44 rows
Threshold Bit Score: 51.903
Threshold Setting Gi: 302754020
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGX90215      12 PCHPRACAIQgsysDPMG-NNYNEARCQDVIKALYTCCESFYKRHG--DSASSPSCPKPSLLRLKMKQ 76  Cordyceps militaris CM01
XP_003227844   6 PCQKYACEIQ----KCLQaNNYVESKCEAAIQEMRKCCVRYPKGR-------SISCSGFESEEKAKQK 62  green anole
EDX08106       8 PCKPNACRIQ----ACLTkNHYQEDKCLDVLEAMRQCCLKWHKE--------SLCCSGIDLEKTYLPD 63  Drosophila simulans
EDS35093       9 PCKVSACRIQ----TCLKeHKFDETRCYDVLEAMRQCCLKWHQV--------SLCCSGIKLDRDYLAD 64  southern house mosquito
EFA00720       6 PCKVFACRIQ----KCLEdNKYQESACQHAIEDLHNCCRKWTNQ--------SFVCEGIRIDPAPRKE 61  red flour beetle
EFN77414       6 PCKQFACKLQ----KCLNdNIYQPSHCQSVIEELRICCKKHTRD--------SLVCDGIDITRQYQHN 61  Jerdon's jumping ant
EFN74971       6 PCKQFACKLQ----KCLKdNVYQPSRCEEIIEELRKCCVKHSST--------STVCDGIDTSKRYEHN 61  Florida carpenter ant
G2TRJ8         3 DCQKEACNLQ----SCIQrNQYNQGNCEKFVNDLLLCCKRWYDKNSltGNEAPHTCPELKPLLRQLSS 66  Schizosaccharomyces pombe 9...
XP_007416662   9 ICQLEACQLQ----KCLNrFTYQPERCEELVKRLYKCCKVMYDENG--DQIKSTACASKEKVKEKIEK 70  Melampsora larici-populina ...
EDR07833       6 TCQTEACDLQ----SCLNrNTYAPEKCEKNLRSLYECCQRFYKLTE--GRGESTSCPLPNVVQRWMRD 67  Laccaria bicolor S238N-H82
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