2FSQ


Conserved Protein Domain Family
2H-phosphodiest

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pfam08975: 2H-phosphodiest 
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Domain of unknown function (DUF1868)
This group of 2H-phosphodiesterases comprises a single family typified by the protein mlr3352 from M.loti. Members are also present in various alpha-proteobacteria, Synechocystis, Streptococcus and Chilo iridescent virus. The presence of a member of this predominantly bacterial group in a large eukaryotic DNA virus represents a potential case of horizontal transfer from a bacterial source into a virus. Several proteins of bacterial origin have been noticed in the insect viruses (L.M.Iyer, E.V.Koonin and L.Aravind, unpublished observations and these appear to have been acquired from endo-symbiotic or parasitic bacteria that share the same host cells with the viruses. Presence of 2H proteins in the proteomes of large DNA viruses (e.g. T4 57B protein and the Fowl-pox virus FPV025) may point to some role for these proteins in regulating the viral tRNA metabolism. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family.
Statistics
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PSSM-Id: 401067
View PSSM: pfam08975
Aligned: 14 rows
Threshold Bit Score: 144.404
Threshold Setting Gi: 326650817
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2FSQ_A           30 RFSAEGEFLPEPGNTVVCHLVE---GSQTEsAIVSTRQRFLDXPEASQLAFTPVSSLHXTVFQGVIESRRALPYWPQTLP 106 Agrobacteriu...
WP_012330489     59 KFTSRGKLLPCPGNTIVCPIDI---DGPAA-ALMAYRATIAAEPYADKFVFTPPSSYHMTVFEGVVDLVRKPGFWPADLP 134 Methylobacte...
Q9A7D3           44 KFDADGRVKPFAGNTIICHVPQqgpGSETFdALLDIYRQLPVHAFAAKVTALPPSSHHMTIFGGANDQDRKPGLWPADLP 123 Caulobacter ...
EPS37077         56 KFDVDGKVQPYAGCTVTSPLSS---SSELHvSLVSLYEKLAASHLSNLYALLPTTSWHMTVFEGLTNPER--DYWPKYLK 130 Dactylellina...
XP_013961074     31 KFDDKGNVLPFPGNTIISHLPQ---DSELYkTLLPIHEILQKSRFTKFYTLLPPPSWHMTDFEGVCDHQRKRETWPQELA 107 Trichoderma ...
XP_006969382     23 KFDTNGNVLPFPGNTIVCHLPQ---DSQLFkALLSIHEKLQQSRFTKFYALLPPTSWHMTVFEGVCDQRRKPGVWPKDLA 99  Trichoderma ...
IEC:ABF-0018567  50 KFNPDGSVRRFPGNTIISHIPL---GSSASnAFTAVRDTLRQQDFSPCLAFTPPSSYHMTVFEGVTESKRKLPFWPADLP 126 Dickeya dada...
Q8PED2           43 KFLRSRRPMPFAGNTFVGHLEQqgdGYASFdRVLDIYRELPEHGFANKLAVLPPSSYHVTLLGGVNETDRAHGPWPSDLA 122 Xanthomonas ...
Q163H6           17 Y--SRTAFLPEAGNTVICHLDT---AHPTHhAILAARSKMQALRGAQRFLFTPAASLHMTVFEGAIETRRTADAWPKDIS 91  Roseobacter ...
Q28U92           19 RYDAE-RFLPDPGNTVVCHLDL---DSPGGaAVLRARAAMKALPGADRLLFTPEDSLHMTVFEGVLDARRRPNAWPSFVD 94  Jannaschia s...
2FSQ_A          107 LDTPIDAVTDYYRDRLSTFP--TLPAFNXRVTGLRPVGXV 144 Agrobacterium fabrum str. C58
WP_012330489    135 LDAPLGQCDRVFLEKLETFDlgCAPRFRMKVAEGASNRDV 174 Methylobacterium sp. 4-46
Q9A7D3          124 LDLPMADCDRLLGERLKAFRldCDLPLRMRVNLAEPAASE 163 Caulobacter vibrioides
EPS37077        131 -DKSMDEVVAIFKSKLENFDlqCELPFRLSVVGfdplqka 169 Dactylellina haptotyla CBS 200.50
XP_013961074    108 LDAPLQKCHDLFRDKLSTFDlgIQPPLKLSVTGLVMSKAG 147 Trichoderma virens Gv29-8
XP_006969382    100 LDAPLQSCHDLFHEKLSKFDvgIQTPLRMAVTGIIMSKAG 139 Trichoderma reesei QM6a
IEC:ABF-0018567 127 TDAPMQSCTDHLARKLVGFDlqATLPFKLRITDFNARqds 166 Dickeya dadantii 3937
Q8PED2          123 RDAALADINASFLSRLQQRNttPLGACRFVVDPTAAMTGS 162 Xanthomonas campestris pv. campestris
Q163H6           92 RDAGIDHATAHVLERLAGFV--PPPAFSVRIAGVAPTGLI 129 Roseobacter denitrificans OCh 114
Q28U92           95 VAAPVAHVTEAMRVRLDGFE--GPGAFEVAVAAVRPGGME 132 Jannaschia sp. CCS1
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