Conserved Protein Domain Family
Sda

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pfam08970: Sda 
Sporulation inhibitor A
Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilized by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A).
Statistics
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PSSM-Id: 370219
View PSSM: pfam08970
Aligned: 18 rows
Threshold Bit Score: 44.5274
Threshold Setting Gi: 288546349
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
PRJNA212797:N288_22105  1 MSSlllLSDENLFKVFEDALLCDVDTDFIRLIADEINRRQLSHLLPVA 48  Bacillus infantis NRRL B-14911
ADC50232                1 MHS---LSDDVLIQSYYRAQEYGLDDDFLDLLFRELCKRNLQHLASQL 45  Bacillus pseudofirmus OF4
Q9K7P9                  1 MDN---IHDDVLIEAYVRAKELNLKQDFIELLMNEMVRRCLPFQEEGi 45  Bacillus halodurans
Q5WIV5                  1 MKT---LSDNILIEACKNAIKLNLDPDFIHLLLKECQRRNISISHH-L 44  Bacillus clausii KSM-K16
Q9KDA9                  1 MET---LSDTFLMEACKYAIKLNLDPDFIHILIEECERRSLPIPENDL 45  Bacillus halodurans
BAM47211                1 MDK---LTNELLLECYEKAVELNLDEAFIRLIEQEIYSRSLTHMISGf 45  Amphibacillus xylanus NBRC 15112
Q9KCW7                  1 MK----LSDQQLLEAYDQALKLELEDDFISVLKEEMIKRNLEVDKDIE 44  Bacillus halodurans
MA:Aflv_0810           14 MKC---LPDDLLIESYYKAKELQLSKEFIQLIEREIFRRRLHHKLKQT 58  Anoxybacillus flavithermus WK1
jgi:GWCH70_2461         1 MKH---LSDELLIESYYKAKELKLSPEFIELIEKEIHRRSLGHKIKLS 45  Geobacillus sp. WCH70
Q8EPU6                  1 MEN---LSDELLLESYYTACELQLSPDFLSLFEEEIHKRCLSHKIKNT 45  Oceanobacillus iheyensis
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