5IFE


Conserved Protein Domain Family
SF3b1

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pfam08920: SF3b1 
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Splicing factor 3B subunit 1
This family consists of several eukaryotic splicing factor 3B subunit 1 proteins, which associate with p14 through a C-terminus beta-strand that interacts with beta-3 of the p14 RNA recognition motif (RRM) beta-sheet, which is in turn connected to an alpha-helix by a loop that makes extensive contacts with both the shorter C-terminal helix and RRM of p14. This subunit is required for 'A' splicing complex assembly (formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA) and 'E' splicing complex assembly.
Statistics
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PSSM-Id: 401026
View PSSM: pfam08920
Aligned: 43 rows
Threshold Bit Score: 106.292
Threshold Setting Gi: 312215590
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5IFE_C               332 SKRKSRWD----ETPASQMgg-----------------------------------stPVLTP------------GKTPI 360  human
XP_001613109         265 RKKISRWDkvgeGTTASAAdglaqsdlmktprvvaaggvalggmaaggmaaggatpggLLKTPylvpg---sgnfVNTPY 341  malari...
Q4UCL9               138 KKKVSRWD----KTPMm---------------------------------------------------------eQQTPM 156  Theile...
Q7RM47               221 KKKISRWD----RTVENSTssnnnnnfgd--------------------gkmassgmnQLKTPiisgnkynenmiINTPI 276  Plasmo...
EME38464             240 ATKKSRWD----STPA---------------------------------------------LDggaapakkkskwDLVSA 270  Dothis...
CCG81011             308 TTKRSRWD----ETPV----------------------------------------------Pvngast-krsrwDQTPA 336  Taphri...
CBX95542             223 SSKRSRWSep-ePEPE---------------------------------------------KPaedaap-vrsrwDTTAV 255  Leptos...
EMD94120             219 PKKRSRWS----PAPE---------------------------------------------DTkeaaap-arsrwDTTAV 248  Bipola...
KDE09112             258 KKKRSRWD----ETPAQAAt-------------------------------------aGSGAPgetpr---rsrwDQTPV 293  Microb...
WGS:AACS:CC1G_00913  178 KKRRSRWD----AAPPD------------------------------------------VQQPaetpk---rsrwDQAPA 208  Coprin...
5IFE_C               361 -------GtpaMNMATPtpg---------himSMTP-------EQLQAWRWEREIDERNRPLSDEELDAMFP---EGYKV 414  human
XP_001613109         342 vvnqlgnA---PAMFTP---------------MMTPgvaslatDSIIRMKIKNEMEIRNRPLTDEDLDELLPs--EGYEI 401  malari...
Q4UCL9               157 aht------gmYGMATP----------------MTPqiv--vpESMLKFNITTSYEDRNRYLTDEELDELLPv--EGYEI 210  Theile...
Q7RM47               277 l---------gTNIMTP----------------ITPysgsvqnNDYIKIKIKNEMDYRNRPLTDEDLDNLLPi--DGYEI 329  Plasmo...
EME38464             271 geqttqvQp----nAAP----------------AQP-----------MAGFGTDISGRNAALSDEELDEMLPs--eGYKI 317  Dothis...
CCG81011             337 ----------------Pgsvs--------akqVTAP-------AAVIPTSFGTDVAGRNLPLSDEELDELLPk--tGYKI 383  Taphri...
CBX95542             256 ---------------VPasatpaapaangahpFMPP-----------TFAFGTDISSRNAPLSDEQLDMMLPgeaEGYKV 309  Leptos...
EMD94120             249 ---------------APaatatpap-aangahpIAP-----------TFAFGTDISSRNAPLSDEQLDMMLPgeaEGYKV 301  Bipola...
KDE09112             294 -----------GVAQTPnaag--------lygAMTPfkgatgsNASIPG-AGQLIDPRNRYLSDEELNQMLPt--EGYEI 351  Microb...
WGS:AACS:CC1G_00913  209 ------------VQDTP----------------MQP-------IIMNAPGVMHE-DKHNRYLTDEELDALLPt--SGYAI 250  Coprin...
5IFE_C               415 LPPPAGYVPIRTPARKLT------ATPT-PLGGM---T 442  human
XP_001613109         402 VQPPEEYEAIRRNKLKAFfktvasAAGT-PLLVGsgaT 438  malaria parasite P. vivax
Q4UCL9               211 VLPPPDYQPYRKPSSYTY------GTVT-PHftipddv 241  Theileria annulata
Q7RM47               330 VKPPEEYETIRKNKLKILfknmndTTTT-PLIQGnknv 366  Plasmodium yoelii yoelii
EME38464             318 LDPPPGYEPLRAPARRLA-----------PSATPvntG 344  Dothistroma septosporum NZE10
CCG81011             384 LIPPPGFEPIRAPAKRVQ------VEDAd--------G 407  Taphrina deformans PYCC 5710
CBX95542             310 LEAPPGYEPVRRPV----------GMPVlPTGY----Q 333  Leptosphaeria maculans JN3
EMD94120             302 LEPPPGYEPVRRPV----------GMPAlPTGY----Q 325  Bipolaris maydis C5
KDE09112             352 VDPPAGYAPIRTPARKLQ------ETPM-AMNGGgfim 382  Microbotryum lychnidis-dioicae p1A1 Lamole
WGS:AACS:CC1G_00913  251 VTPPPGYAPLVAP-RNLM------ATPVtk------iE 275  Coprinopsis cinerea okayama7#130
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