1UIX,1S1C


Conserved Protein Domain Family
Rho_Binding

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pfam08912: Rho_Binding 
Rho Binding
Rho Binding Domain is responsible for the recognition and binding of Rho binding domain-containing proteins (such as ROCK) to Rho, resulting in activation of the GTPase which in turn modulates the phosphorylation of various signalling proteins. This domain is within an amphipathic alpha-helical coiled-coil and interacts with Rho through predominantly hydrophobic interactions.
Statistics
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PSSM-Id: 401020
View PSSM: pfam08912
Aligned: 42 rows
Threshold Bit Score: 44.9171
Threshold Setting Gi: 196016114
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UIX_A          4 SDVANLANEKEELNNKLKEAQEQLSRLK-D---EEISAAAIKaqfeKQLLTERTLKTQAVNKLAEIXNRKE 70  
NP_001171981  949 NRIMTLNTEKDELNKKLKESSEAQEAME-T---KHQEMEKQMeqnkKLLGEEKLKKEQAVSKLAEIMNRKD 1015 purple sea urchin
5_pfamImport    3 TQVEDIRKEKETWSKKLESANEEIEALK-Q---TALQVATMKagyeKSLNQEKMLKLQAVNKLAEILNRKQ 69  
Q29IT7        953 KKLGQKANEYEDLVQQHKKQQDELGQLRaT---KDEEITKLL----DKCKTEVLLKQVAVNKLAEVMNRRD 1016 Drosophila pseudoobscura
XP_015025050  954 KKLKQKASEWDELLVQHKKQLDELQQQRaA---KDEEIAKLG----EKCKNEVLLKQVAVAKLAEVMNRRD 1017 Drosophila virilis
Q179S5        890 KKLNNKAFELDDLTQQNRKMQDELSVLKsE----QSEMEKLR----TKLKTETMLKQQAVNKLAEIMNRKD 952  yellow fever mosquito
Q7PRV2        938 KSLGNKEYELEDVLQQSKKQQEELYRLKyE----LGELDKCR----AKLVNETILKQQAVNKLAEIMNRKD 1000 Anopheles gambiae str....
ETN67237      884 KNLTNKSYELDDLMQQCKKLQDELYVLRlE----QGELDKCK----TKLLNETILKQQAVNKLAEIMNRKD 946  Anopheles darlingi
NP_001265264  944 KNVDQYLKEKEDLNKRFKELQDQLSKAQ-S---NAEEIEKLS----SKLKTEQLLKQQAVNKLAEIMNRKD 1006 honey bee
EKC40137      877 KEIEELTAEKNDLNSRLQKLSEDLRQVQsQsggSSSEIEKLK----KNLEEEKLKKIQAVNKLAEIMNRKE 943  Pacific oyster
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