3TJ3


Conserved Protein Domain Family
NUP50

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pfam08911: NUP50 
NUP50 (Nucleoporin 50 kDa)
Nucleoporin 50 kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C-terminus of NUP50 binds importin-beta through RAN-GTP, the N-terminus binds the C-terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localization signals from importin-alpha.
Statistics
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PSSM-Id: 401019
View PSSM: pfam08911
Aligned: 78 rows
Threshold Bit Score: 34.1873
Threshold Setting Gi: 527303711
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3TJ3_C         8 KRNAEKELTDRNWDq-------EDEa----EEVGtFSMASEEVLKNRA--IKKAKRRN------------------VGfe 56 
KDE05471       3 KRGADKQLTDQNWErdas-ddeDNNst--gSGEAsFKTAAPEALAGRR--IRGLPQRK------------------GAgg 59  Microbotryum ly...
OAV91185       3 KRQAEKQLTDRNWNd-------QEPdd--tPSTGaLKTASLQAISKRQ--IRSLPKKT------------------GAsa 53  Puccinia tritic...
XP_007396926   2 KRGAEKQLTKDVed------idDDEvv--eSGQG-LKKADDNMLANRK--IRGLPKRAtag-------------laSGsa 57  Phanerochaete c...
ESK96637       2 KRVADRQLTKDHED--------EEDde--sQEQSvFKKADDSVLASRQ--IRGLPRRAqktassssivsnasteadSNet 69  Moniliophthora ...
XP_001830289   2 KRVADKQLIREEADve-----eTNDtg--ePGTG-FRKADEAVLATRKqvIRALPKRAagg------------sfnAAat 61  Coprinopsis cin...
EDR11859       2 KRGAEKQLVKDAFD--------DDSnedesPSQG-FKKADEAVLAARP--MRGLPKRV------------------TTst 52  Laccaria bicolo...
EKM80640       2 KRGAEKQISKDSFEe-------EEEqe--eTPQTgFARANESVLKTRP--MRGLPKRAs-----------------VAsl 53  Agaricus bispor...
XP_003030483   2 KRGAERQATRDDADn-------DGDdn--ePGQG-LKKADEATLAGRK--IRGLPKRS------------------RSst 51  Schizophyllum c...
EPT04488       2 KRGATRQLTKDEDVdddrdddgRDDde--ePQQG-LQLADAATLAKRP--MKSLPKRRga--------------gaSGsd 62  Fomitopsis pini...
3TJ3_C        57 sd-------------------------------tggaFKGFKGL 69 
KDE05471      60 ptpaaatst------------------ssaaaptpspFGSFSGF 85  Microbotryum lychnidis-dioicae p1A1 Lamole
OAV91185      54 spaa----------------------------sqfgaVPPFPAI 69  Puccinia triticina 1-1 BBBD Race 1
XP_007396926  58 ptla----------------------------avpskFAGFAGF 73  Phanerochaete carnosa HHB-10118-sp
ESK96637      70 psatpptt--------------------tttttttttFGGFGGF 93  Moniliophthora roreri MCA 2997
XP_001830289  62 psaaa-------------------------atnappkFGGFAGF 80  Coprinopsis cinerea okayama7#130
EDR11859      53 ptpanp-----------------------sapastpkFGGFNGF 73  Laccaria bicolor S238N-H82
EKM80640      54 pppatq-----------------------tgvadtprFNGFSGF 74  Agaricus bisporus var. burnettii JB137-S8
XP_003030483  52 paattd------------------------apssapkFAGFSGF 71  Schizophyllum commune H4-8
EPT04488      63 kpqiqvpkngavyfgrtrdpseaaaatatsepepapkFGGFGGF 106 Fomitopsis pinicola FP-58527 SS1
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