1YOV


Conserved Protein Domain Family
E2_bind

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pfam08825: E2_bind 
E2 binding domain
E1 and E2 enzymes play a central role in ubiquitin and ubiquitin-like protein transfer cascades. This is an E2 binding domain that is found on NEDD8 activating E1 enzyme. The domain resembles ubiquitin, and recruits the catalytic core of the E2 enzyme Ubc12 in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.
Statistics
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PSSM-Id: 400951
View PSSM: pfam08825
Aligned: 130 rows
Threshold Bit Score: 60.2017
Threshold Setting Gi: 123491499
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YOV_B       357 FSPSAKLQEVLDYLTNSASLQMKSPaitaTL---EGKNRTLYLQSV--TSIEERTRPNLSKTLKELg----lVDGQELA- 426
2_pfamImport   1 --DSMTLQNLIDHLC-GDNFWLSKP----SIs---sGSANLFMQGP--PSLRAATSPNLDKTLRELv-----KDGESLT- 62 
Q22T77       347 ISRSTKLQELQDLLKEKPF-ELTDP----SL-----TADNGSMLIP--VVMRNQHAEKLPMSFTQLiaeghyQEGLIIH- 413 Tetrahymena the...
XP_004031048 361 ISKNMLLKDFQKLLQSKPY-EFLDP----SL-----TGQDGRLIIP--VVMRDLHKEKLEMTFDQLaqqniyKEGEIIY- 427 Ichthyophthiriu...
XP_001325848 189 LNDNETVSEFIQRL--EKEYNLKNA----RLvinTDNDRIIPIYSP---KIYKESQGNLSKPMKNFv-----ESGSEIIg 254 Trichomonas vag...
Q19360       349 VSPSSTLESLIIRLSE--RFHLKHP----TL---ATSTRKLYCISSfmPQFEQESKENLHTSMKDLv-----SDGEEIL- 413 Caenorhabditis ...
6_pfamImport   2 IHPTATFESLVTRVTE--KFHLKNP----TL---ETALRKLYCISLlfPQLEEESHRNLHLSIKDVl-----HDGDEVL- 66 
CAP34451     349 VSSTYTLEELINSLME--RYHLKNP----TL---ETAQRKLFCISLlfPQLEEESKANLHLFLKDIv-----ADGDEIL- 413 Caenorhabditis ...
ESS33614     493 dPDETSLQDLLELLSQDPALNLKGP----GIs---sATAVLFLQKP--PQLRQQLETNLRKSLRELadsgmlKEGEELL- 562 Toxoplasma gond...
CCX30751     350 IDPEWTLQDFIDHLAAKPDLQIKKP----NL---KRNHAQLYEHDN-----AAEYSTGLDKKMREMv-----AEGEELE- 411 Pyronema omphal...
1YOV_B       427 VADVTTPqtVLFKLHF 442
2_pfamImport  63 ITDAVFVgdMALSLQI 78 
Q22T77       414 VTDKKLFapAKIQIHF 429 Tetrahymena thermophila SB210
XP_004031048 428 ITDQKIHsvAKVIVSF 443 Ichthyophthirius multifiliis
XP_001325848 255 ITPDNLDstYIIRIi- 269 Trichomonas vaginalis G3
Q19360       414 VSDEALSraLTLRIQL 429 Caenorhabditis elegans
6_pfamImport  67 LSDVALPraITLRIRF 82 
CAP34451     414 VSDEVLAraITLRINF 429 Caenorhabditis briggsae
ESS33614     563 VTDVALPstLRLRLFF 578 Toxoplasma gondii VEG
CCX30751     412 VRSEL-PfvSKFSLVF 426 Pyronema omphalodes CBS 100304
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