2L81,1Z23


Conserved Protein Domain Family
Serine_rich

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pfam08824: Serine_rich 
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Serine rich protein interaction domain
This is a serine rich domain that is found in the docking protein p130(cas) (Crk-associated substrate). This domain folds into a four helix bundle which is associated with protein-protein interactions.
Statistics
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PSSM-Id: 400950
View PSSM: pfam08824
Aligned: 54 rows
Threshold Bit Score: 138.849
Threshold Setting Gi: 195996721
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2L81_A        17 LDPDTAIERLQRLQQALEMGVSSLMALV-TTDWRCYGYM--ERHINEIRTAVDKVELFLKEYLHFVKGAVANAAC----- 88  human
XP_015788323 369 LNLDSGLTLANRLENESLQAINKLIELSsKDSWRKLENL--RPVLDELMKCCSQLRFVTRELEVFTDGLYVNSLK----- 441 two-spotted spi...
EFX84699     525 LPLDAALETLSRLDAEVSSAISNLLSF-----WRAAS----GGDWAELQLRVLRLRASLQELCDFARGAIGNASQrlkng 595 common water flea
XP_001943111 268 IDLNCALECLDKLTSEVSSNTTQLLNYA-GPNWRSQKNL--EANLLDIKIISLRLKNSLYQFIEFSEGCLGNAVN----- 339 pea aphid
EEB14100     247 LELNSALETLNRLQNEASGAVQRLLGLL-SPGWRRLDNL--QNRIFDIKLAAERLRTSLHELSEFCEGSLGNAYK----- 318 human body louse
XP_002065969 164 LELNSALETLAKLQSQTTMAITRLLSFV-VPNWRIRSQL--EPCIMDLKLAALRLRTALHDLAEFGEGALGNATR----- 235 Drosophila will...
Q174Y6       164 LELSSALETLARLQNEATSAVSRLLGFV-SPNWRTKEKL--DPILMDLKLAAVRLRTALHDLAEFGDGALGNATK----- 235 yellow fever mo...
5_pfamImport   1 LEMNSALEWLGRLESDVTSGISGLVGVA-TIGWRSRANL--EPRLSELRWSVSRLSSSLHDLTLFCQSVRAAHH------ 71 
XP_002434429 455 LERDAALEMLVKVQQEVSSAISKLFSLT-HSTLKRQESAtnESRLYDLKTSCHKLRTSLREFLNFAQGALANAAH----- 528 black-legged tick
EFN70956     265 LELDSALEGLQRLQNEASAAIARLLGFV-SPGWRTPQRL--DATLMDLRLAALRLRTSLHDLAEFAEGTLGNAGK----- 336 Florida carpent...
2L81_A        89 LPELILHNKMKRELQRVEDSHQILSQTSHDLNEC-SWSLNILAINKPQNk---------------CDDLDRFVMVAKTVP 152 human
XP_015788323 442 NSSSSINNKLYRLSRQLKDSAHIVISTIQSLNSR-GWNLNELTELKKTS----------------HDELDQLIACMPGLK 504 two-spotted spi...
EFX84699     596 VGDQGVTIRLIRLLRPLQDANAIVQKTSQS-------CMDLFATSRRRPns------------enDAELDQLLACCRNLG 656 common water flea
XP_001943111 340 ARDKGISTKLHPLVFDLMKTDKMISFSTNALDCL-DWKPHLLHRDSNNEce------------ysEDALDKLISCAKLLT 406 pea aphid
EEB14100     319 AADKNLVIKLKPLAKALRDADKIVQETCNELDVM-NWSIQDLSRDSDQDs--------------sLDNLDRLIACAKSLT 383 human body louse
XP_002065969 236 SEDRNLALKLRPLVRALRDANKLIHDTSEALDAQgGWSVDQLARNDEKHgc------------rpPDSLDQLMACAQTLT 303 Drosophila will...
Q174Y6       236 AEDKGLAQKLRPLVKALRDADKLVHEASQNLDNQ-GWTMVTLQRPEATQklqq---------qlpPDSLDQLIACAQTLT 305 yellow fever mo...
5_pfamImport  72 --DKGLGGKLGPLVASLTKADLLVKECCQSLEFS-GWSTTLLAVEDPDIh--------------qPDALDALVSCAAALT 134
XP_002434429 529 LEDRKLCQKLARLAKPLVDSYQVVVTTTQALDDK-GWQISATRDTSAG-----------------PDELDQLIACARGLT 590 black-legged tick
EFN70956     337 APDKGLATKLRPLVKALRDSDKLVQEAATELDTM-EWDASKLCRGGGDTptptngpppsllppvqPDPLDQLIACARALT 415 Florida carpent...
2L81_A       153 DDAKQLTTTINTNAEALFRP 172 human
XP_015788323 505 EDIKHIMSIVKSCGNLLFPE 524 two-spotted spider mite
EFX84699     657 DDMRQVVTFIQSNGHLLFDT 676 common water flea
XP_001943111 407 DDIRQITSFIKGNSTLLFKK 426 pea aphid
EEB14100     384 EDIRRAASSLQGNAPLLFKR 403 human body louse
XP_002065969 304 EDVRSTTSFIQGNASLLFKR 323 Drosophila willistoni
Q174Y6       306 EDVRQTASFIQGNGTLLFKR 325 yellow fever mosquito
5_pfamImport 135 DDIRQVTSFIQGNATLLFKK 154
XP_002434429 591 EDIQQIASTIQGNSTLIFKK 610 black-legged tick
EFN70956     416 EDVRQVASFIQGNSTLLFKR 435 Florida carpenter ant
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