2A2P


Conserved Protein Domain Family
Sep15_SelM

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pfam08806: Sep15_SelM 
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Sep15/SelM redox domain
Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum. Structurally it resembles the thioredoxin-fold.
Statistics
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PSSM-Id: 400935
View PSSM: pfam08806
Aligned: 33 rows
Threshold Bit Score: 79.5252
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2A2P_A        17 GRVETCGGCQLNRLKEVKAFVTEDI--QLYHNLVMKHLPGADPELVLL---SR-NYQELERIPLSQMTRDEINALVQELG 90  house mouse
XP_973321     76 KAVLEVCTCKFGAYPQIQAFIKSSRp-LQFPNLQIKYVRGLDPIIKLY---DK-DGTLQETVAIEKWNTDSVEEFLKTHL 150 red flour beetle
EFJ39998      31 AEFISCPGURLNHLPEVKRFLKGDIeqGAYENVAVNFIPGRIPELVLY---DS-NNVEVERMFVDKLKYDELHTLIQTKG 106 Volvox carteri ...
2_pfamImport   1 ARVERCAGKSLNRLKEVKAFVTQDI--PLYHNLAMRHAGVAGPPLGGAggpDS-ALLRLQRIPLSDMTREEINALVQELG 77 
Q802G7        30 ARVETCGGUQLNRMREVKAFVTQDI--PLYHNLVMKHIPGADPELVLL---NH-YYEELDRIPLSEMTRAEINKLLAELG 103 zebrafish
XP_001600851  33 AVVESCRGCQLNRLPDVKAFILEDV--PLYDNAEFKHIQGAPPELVLY---DH-AEKEIERLQIGLLTREECNELMYEKG 106 jewel wasp
XP_015838752  31 ARVESCPSCKLNRLPEVKAFIYEDL--PKYDNTEFKKIQGAPPVLLFL---ND-ADEIVEQHSLEKFSRQECNNLLKSKG 104 red flour beetle
OWR52099      29 ARIETCRGCSLNRLPEVKRFVMDDA--PHFERLEVKFITGAPPELILL---GN-GDKELERIPLSNLSRQECNDLVKSKG 102 Danaus plexippu...
CBN75212      30 GHIVSCSGUKLNKLPEAKKFLKNPEhaASYEDIEVEFKAGKPPVLTLF---DKaSGEETESINLEKFTIDEMHELLVSRG 106 Ectocarpus sili...
XP_013130818  29 aRVETCGGUQLNRLREVKAFVVQDI--PLYHNLVMKHIPGADPELVLL---NH-YYEELDRVALSDMTRSEINELLGKLG 102 Nile tilapia
2A2P_A        91 F 91  house mouse
XP_973321    151 Q 151 red flour beetle
EFJ39998     107 F 107 Volvox carteri f. nagariensis
2_pfamImport  78 F 78 
Q802G7       104 F 104 zebrafish
XP_001600851 107 F 107 jewel wasp
XP_015838752 105 F 105 red flour beetle
OWR52099     103 F 103 Danaus plexippus plexippus
CBN75212     107 F 107 Ectocarpus siliculosus
XP_013130818 103 F 103 Nile tilapia
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