5BNH


Conserved Protein Domain Family
HIRAN

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pfam08797: HIRAN 
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HIRAN domain
The HIRAN domain (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. The HIRAN domain is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes. It has been predicted that this domain functions as a DNA-binding domain that probably recognizes features associated with damaged DNA or stalled replication forks
Statistics
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PSSM-Id: 400928
View PSSM: pfam08797
Aligned: 49 rows
Threshold Bit Score: 56.1843
Threshold Setting Gi: 81760697
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5BNH_A         8 FGSLRGHVVGLRy-yTG-------VVNNNEMVALQRDP-NNPYDKNAIKVNNVNGNQV-GHLKKELAGALAYIM--DNKL 75  human
KPA59038       3 LNVQDFHLAAFAy-yDGldv--idQLKPGTPVQLVGEP-SNPHDSEAVAIF-YQGTKL-GYIPSDKNSLISRLI--YFGH 74  Streptococcus suis
Q5LCS0        68 PGYCYYELGGMRy--QAl-----tGFDIGVHEGYAKAElNNRYDKYAVGVYREGDHKLmGYVRREQNRELYEFM--LNNN 138 Bacteroides fra...
Q5KUR0       132 KLCVSFFVHGMRy--QNlpqnwatWLAINETLKLVQEP-TNTYDPHAVAIYTHGGKKL-GYVPAFYSKAVFSLL--EN-G 204 Geobacillus kau...
Q3SI53        33 IVLQDSPLAGFQy-hAGktl--wpQMQVGDALTLVREP-DNRHDAKAVRVE-WHGHKI-GYVPRRENADVARLL--DA-G 103 Thiobacillus de...
Q47IS2        23 VLVQNSPLAGSQyyaVGel---wqEMKVGDGLDLFREP-DNKHDRNAIRVE-WRGHKL-GYVPRAQNRAVAAAM--DA-G 93  Dechloromonas a...
Q74H43        31 IDLLEVHIAGFQy-hEGmsagvfsMLKRGGELCLRREP-DNPYDPFAIAMETQAGNKL-GYLPRRINGIPAAIL--DQGV 105 Geobacter sulfu...
WP_011969108 540 IYLTSVNIAGTSy-fDMsei--ynKLLEEDIVYLKRDS-DNEYDKNAIEVITTEGFVM-GYVPKDNNLILKNLI--DKGK 612 Clostridium bei...
Q895W7       535 IYLFSTYVAGVYy-rDTsvv--edYIGVNDILFLKEEP-ENPYDKNAILVTNENGYVL-GYLPKSVNKIPKNLL--AGGK 607 Clostridium tetani
Q8PBU2       147 SFEAFFFVRGISy-iPGta---diDLKIGDRLFVMKDF-QNEQDSAALLLRTGDPVSVvGYAPRYYSHDLSRLAelCPPQ 221 Xanthomonas cam...
5BNH_A        76 AQI--EGVVPFGANna---fTMPLHMTFWGKEE 103 human
KPA59038      75 GDIleARIQMSNTEn-----HPDRQFRVVVKLK 102 Streptococcus suis
Q5LCS0       139 CIAkaKFRIWIHQGei--ygAAYIKEEWKSSLG 169 Bacteroides fragilis NCTC 9343
Q5KUR0       205 ANP--SVRVVYMNEkstphwWLKVAFECEIpsf 235 Geobacillus kaustophilus
Q3SI53       104 QTL--DARIVRLAEvr--dpWARVRFEIVIPLn 132 Thiobacillus denitrificans ATCC 25259
Q47IS2        94 DRL--TARVSSLSDnk--npWQRVAFEVFVEL- 121 Dechloromonas aromatica RCB
Q74H43       106 TTR--AEIVEIDALap---pWERVLVRVWQEV- 132 Geobacter sulfurreducens
WP_011969108 613 YLY---GKVEEISEd-----YSVIKIQIYLSYK 637 Clostridium beijerinckii
Q895W7       608 FLY--TIIEEYSLE------SNTISIDVYLSYK 632 Clostridium tetani
Q8PBU2       222 DLLvtVERLNNNAPa-----AYKVLCKVVAPWp 249 Xanthomonas campestris pv. campestris
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