6D12


Conserved Protein Domain Family
RRM_3

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pfam08777: RRM_3 
Click on image for an interactive view with Cn3D
RNA binding motif
This domain is found in protein La which functions as an RNA chaperone during RNA polymerase III transcription, and can also stimulate translation initiation. It contains a five stranded beta sheet which forms an atypical RNA recognition motif.
Statistics
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PSSM-Id: 400913
View PSSM: pfam08777
Aligned: 11 rows
Threshold Bit Score: 92.0458
Threshold Setting Gi: 74855304
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6D12_A         11 GVIVKII--STEPLPgRKQVRDTXAAIS---EVLYVDLLEGDTECHARFKTPLD--ALAVINAYTEI-------NKKHCW 76   human
Q54TG6        229 GVILCFKg-VGKGLH-RGDIKEIFSQYG---EVQFVGYNSDEENGSVRYKTAES--CKRAIESLTETkk----eIGGQIP 297  Dictyostelium...
Q7ZWE3        429 GVIVKIS--YNQPLPsKRCIKDMLSELS---PVAYVDLLDGDTEGHVRFKSSED--AQKVIKARFEF-------QKKYNW 494  zebrafish
O01806        230 GLILAVDg-LGPDST-IDSIKTFFKLHG---SVGYVAHENGGKTAEIRFNNDSEg-AQKAWDNAVAAgtdgkviLQEAEL 303  Caenorhabditi...
Q6K6X2        330 G----LSgkANSPIS-REDLKEAFKKFG---TVRYVDFSIGDESGYLRFEDSKA--AEKARMSAVLAdeg-gliVKDHIV 398  Japanese rice
XP_002638994  232 GLILAVDg-IKGESS-VDSIKTFFKQYG---SVGYVAHEVGNATAEVRFNNDSEggAQKAWEKAVEAgtdgkvmMNDAEI 306  Caenorhabditi...
P05455        231 GCLLKFSgdLDDQTC-REDLHILFSNHG---EIKWIDFVRGAKEGIILFKEK----AKEALGKAKDAnng-nlqLRNKEV 301  human
CAG09938      211 GCLLKFSg-ELEDVS-REDFHELFSGHG---KIKWVDFARGAKEGALLFDGN----AKEAFEKAKEAngg-elkIKDCSV 280  spotted green...
Q7PWI4        261 GACVFMEg-LGKETT-RESIKEAIRALDetlEFAYIDYQKGDASGYVRFNKQDA--GKQLLEKLTDKkl----kIDDAEV 332  Anopheles gam...
Q17EQ5        250 GACVHLAg-FNKETS-RETIKETILKLDeslEVAFIDYQKTDSEGTVRFAADDA--GKKFMEKLTDSki----qIDEEEI 321  yellow fever ...
CAF96679     1532 GVIVKIT--DSKALPaRSRIKDALSRLS---PVAYVDVLEGDAEGHVRFHSPED--ARAACEGRAAL-------QKELGW 1597 spotted green...
6D12_A         77 KXEILSGDHEQRYWQKILVDRQAKL--NQPREKKR 109  human
Q54TG6        298 TYNLLEGEEEKKEWEKIIERKKNAA--KNGGFKKG 330  Dictyostelium discoideum AX4
Q7ZWE3        495 NLELLSGDHERRYWQKILVDRQAKL--NTPREKKR 527  zebrafish
O01806        304 SARVLDGEEEEKYWTEFNARKNQRQggGRGGRGGR 338  Caenorhabditis elegans
Q6K6X2        399 TLEPVTGEAEKDYWNTIRGIQGKYK--DNRSYKGR 431  Japanese rice
XP_002638994  307 TARVLEGEEEEKYWTEFNNRKSQKQ----NFRGGR 337  Caenorhabditis briggsae
P05455        302 TWEVLEGEVEKEALKKIIEDQQESL--NKWKSKGR 334  human
CAG09938      281 TWQLLEGDEEKEALKRIIEAQQETQ-----RNKGR 310  spotted green pufferfish
Q7PWI4        333 TADLLVDEKETEYLKKIAEEQAKRK--VNAKNKGR 365  Anopheles gambiae str. PEST
Q17EQ5        322 TARLLEGDEEKEFLRKVVKDQQARRqaSNARNKGR 356  yellow fever mosquito
CAF96679     1598 RLEVISGEREQRYWQKILVDRQVKL--NRPREKKR 1630 spotted green pufferfish
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