1Q1V


Conserved Protein Domain Family
DEK_C

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pfam08766: DEK_C 
DEK C terminal domain
DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family. This domain is also found in chitin synthase proteins and in protein phosphastases.
Statistics
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PSSM-Id: 400903
View PSSM: pfam08766
Aligned: 252 rows
Threshold Bit Score: 28.1145
Threshold Setting Gi: 75205209
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1Q1V_A         12 PTDEELKETIKKLLASANLEEVTMKQICKKVYENYpTyD-LTERKDFIKTTVKELI 66  
XP_004345410 1039 ELD--VINKLREFMMCSDLDSVTPKEMRTALESHF-N-IdMNYCKKFIDEKILVIM 1090 Capsaspora owczarzaki ATCC 30864
EDQ92582      350 ELEQRIISKLKEIMFKSDLDTITSKQLRLQLEAEF-D-MdLKKYRKIIDQQMITVM 403  Monosiga brevicollis MX1
EFX84171      162 DRERLIRSTLKEVMMTLDLDDVTSVDIRRRVEEEL-Q-MdLTDQKSFLDTEMLTIL 215  common water flea
XP_002001008  336 ETESVIKMKLKAIMMSVDLDEVTSKYIRGRLEDLL-D-MdLGEYKSFIDAEMLRIL 389  Drosophila mojavensis
6_pfamImport    1 SVETLIRDRLKQVMMTMDLDNCTCKQVRLELENVI-D-MdLTAYKRYIDTEMFNIL 54  
XP_011450064  262 QFKKRLNVELKNVMMRMDLEEATCKAIRTELQAAM-N-MdLSEHKSYIDQEMMRIL 315  Pacific oyster
EDO37675      164 LLRKLLRHKLREVMMTVDLEEVTSRQVRELVEAEV-Q-MdLKQYKQYIDKEMLTIF 217  starlet sea anemone
ESN93831      216 QLENVIRLKLKQIMMTVDLEEVTSKYLRTRLEEEM-S-MsLLEWRRFIDDEMIIIM 269  Helobdella robusta
XP_014240169  358 ETEKVIRTALKEIMMSVDLDEVTSKQVRTKLEESL-D-VdLGEFKSFIDQEMLIIL 411  bed bug
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