2YB0,4DK4


Conserved Protein Domain Family
dUTPase_2

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pfam08761: dUTPase_2 
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dUTPase
2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate (EC:3.6.1.23). Members of this family have a novel all-alpha fold and are unrelated to the all-beta fold found in dUTPases of the majority of organisms. This family contains both dUTPase homologs of dUTPase including dCTPase of phage T4.
Statistics
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PSSM-Id: 400900
View PSSM: pfam08761
Aligned: 18 rows
Threshold Bit Score: 136.696
Threshold Setting Gi: 529280981
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2YB0_E          16 ILHSLAELQDGLNAMIDPSW-----RAvrsldnwA-----LAITMESTELLDSY-PWKWWKNLNaTPDLANVRIELVDIF 84  Leishmania major
tigr:GBAA_3815  17 DITELFEMQKELDKRIGYKGn----DKmd----mLf----RALLVEISEAWNETrAFKMWSTGF-GVPKNGLLEELIDGL 83  Bacillus anth...
Q6F1K9           6 TLKWLSEQQEFLDNKIIEKHnltldHEi------Frk-klIAFWVELGEYANEEkSFKYWKQGA-PGAKEVQLEEYIDGL 77  Mesoplasma fl...
Q6MTA1           6 tLKWLNEKQIILDQFIQNKWnfkndKTl------Ldk-klTAFLVELGEYANEErSFKYWSNKK-PSGLEIQLDEYIDGI 77  Mycoplasma my...
Q30TB7           3 KILLMLQLQATLNEATNGDGwtsgvTKnskvinwK-----RCIYMECAEMIGSF-SWKHWKNIDqEADWANLQIEVVDVW 76  Sulfurimonas ...
4DK4_B          16 ILRSLAELQDGLNTVVDKNW-----RQlrrpgdwS-----LAITMEAAELLDSY-PWKWWKNVKaQPDLQNVKIELTDIL 84  Trypanosoma b...
Q47UU7          15 QISQMLVMQDAMNSRVSDTWreng-------yewY-----RAIWVECAEMLDHH-GWKWWKHQE--IDIAQVQLELVDIF 79  Colwellia psy...
Q4A5X7           2 NLKEIFLRQKALDEKILQKSns--lRSekldsnyRfklasIALLVELAEFANEIeSFKYWKANK-KDNSAKIREEFADAL 78  Mycoplasma sy...
Q6KI21           2 NLRKILDLQRELDKSIHFAHeidktKNl------Kte-kiLAFFVELGELANEIqFFKYWKKDK-KLDWKKILEEYSDGL 73  Mycoplasma mo...
Q98QA9           3 NIEKMLREQEKLDNLILKKCnilnfEA-------VqnkvaLALLVEVSELANEVqSFKYWKLSK-QIDLAKVKEEYSDGI 74  Mycoplasma pu...
2YB0_E          85 HFSLSGAMQMRSTPDDEipa-------------------------------asLKPLKEVMTTFLpakectsdpygfVFf 133 Leishmania major
tigr:GBAA_3815  84 HFLMNIVIELDKCTWRHelip-----------------------------sfsMQSIMRKDTSNVnml------fewYMq 128 Bacillus anth...
Q6F1K9          78 HFIISLGNQINYNFETFn-----------------------------------FNDLGYNNNIDC------------YF- 109 Mesoplasma fl...
Q6MTA1          78 HFIISVANQINYNFLEFn-----------------------------------YNFLNKESIIDI------------YF- 109 Mycoplasma my...
Q30TB7          77 HFIMSLAIENYANSHKG------------------------------------GVEELALDISELenfckidtknelFAs 120 Sulfurimonas ...
4DK4_B          85 HFSLSGAMQVSDENSGAvhkaeagsngesgkhwcyfdqpralpaaggaeyvacVETPGSSLSAPVsadec--dladfMFf 162 Trypanosoma b...
Q47UU7          80 HFGLSLRLMSGDSAEL-------------------------------------IASELSKELHQG--------------- 107 Colwellia psy...
Q4A5X7          79 HFLVSFANEYKICYNV-------------------------------------STKIISDDINIQ------------LI- 108 Mycoplasma sy...
Q6KI21          74 HFLSSFILESNGSEII-------------------------------------EPIVISNNLNFQ------------FL- 103 Mycoplasma mo...
Q98QA9          75 HFLNSISFYYQLSNLI-------------------------------------PFKVISPDINEQ------------FR- 104 Mycoplasma pu...
2YB0_E         134 pltdtqNAIASFRNIIQLA-NA--YRFDVIIECIIYAAEDLGFN---LVAYYIAKHTLNCIRQLSGY 194 Leishmania major
tigr:GBAA_3815 129 dvltakRAWCQYRDLTTTM-----GHLRRAFGIFFRICYLYGFTyedVIDSYKEKNAENFERQENGY 190 Bacillus anthracis str. 'A...
Q6F1K9         110 ------ELIKDLTALVNQP-ND--QTFSKILNSFLQIAKVQNYSeedLIKTYKAKHEKNQQRQVENY 167 Mesoplasma florum
Q6MTA1         110 ------EIISCLNSFIKEN-NN--TNYSNLLNAFLNICEIKNYTqeqIINAYNIKNEINFQRQNNNY 167 Mycoplasma mycoides subsp....
Q30TB7         121 q----dEIMQKVESIIFNVlNRdnFELEKLIEEFFDLVVMSGLDletLYKLYVGKNILNQFRQDNGY 183 Sulfurimonas denitrificans...
4DK4_B         163 plsdtnNALASFQNIIRLA-SL--QRFQLVTSAVIAAADDIGFN---LVAYYVAKHTLNGIRQMKGY 223 Trypanosoma brucei
Q47UU7         108 ------TAESDFKIALENLaSAavTSRAFDAKALADCMSLMNMDldeLFRQYVGKNTLNFFRQDHGY 168 Colwellia psychrerythraea 34H
Q4A5X7         109 ------EILKSVVDFFNDL-NK--EKLTKAFELILGIYQMLGYTeadLLSDYIKVNEKNLKRLENNY 166 Mycoplasma synoviae 53
Q6KI21         104 ------EILKQINELEENF-SK--KSTEKIFSLYLGIAKILKISdeeIEAEYIKKNIINHERIKNKY 161 Mycoplasma mobile
Q98QA9         105 ------AVFISIAEFMKKP-SK--ESILEVYSLYLGIAKLLNISneeIEKSYFEKNLINQKRAKGSY 162 Mycoplasma pulmonis
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