Conserved Protein Domain Family
HUN

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pfam08729: HUN 
HPC2 and ubinuclein domain
HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription. It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes. Hpc2 is one of the proteins of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone proteins. the Hip4 sequence from SCH. pombe is an integral component of this complex that is required for transcriptional silencing at multiple loci. HPC2, ubinuclein/yemanuclein, and the cell cycle regulator FLJ25778 share a conserved domain that is predicted to bind histone tails. This domain is also referred to as the HRD or Hpc2-related domain.
Statistics
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PSSM-Id: 400875
View PSSM: pfam08729
Aligned: 35 rows
Threshold Bit Score: 32.6208
Threshold Setting Gi: 74858138
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFC45863         219 KSTKKKKEEEKRRFDYDSEDSFID------------DTEydvIATDFPMIphqeAQQLEKHT-----FYDDEDSEE 277 Naegleria gruberi
EPT00040         160 KKRRKKKNRASEY--YDTADPFID------------DSE---LAQDERTF----FAQTKQKG-----FYVSSGQVa 209 Fomitopsis pini...
Q5K8G8           340 KKKKRPTD-------YDLEDPFID------------DSE---IMIDAPTH----YARPAREG-----FFVHSGPLQ 384 Cryptococcus ne...
Q55BH3           342 FHYYLDSDGDSTISEYDIEDPFVDdslllikdhahsDSN---GIDDDSDD----INNLETNG-----FYVIQNGID 405 Dictyostelium d...
GAC74953         338 KRRKVNDDKYDIG-QYDVRDPFVD------------DSE---LNIDEPTH----FAKPKADG-----FYVTQGTVE 388 Moesziomyces an...
jgi:MICPUN_58884 263 KQQKRGGKNQYVEEWYDMDDDFID------------DDE---LDEYFERT----GRKDKLGGkggdrFYVNAGQIE 319 Micromonas commoda
1_pfamImport       1 GDEGGGLDRRDDDDLYDSEDSFID------------DVE---LQQNIEDArgqtRVQTKHVG-----FFVNAGEEI 56 
JCVI:AT1G21610.3 113 sSDGEELDGAPDDDEYDTEDSFID------------DAE---LDEYFEVD----NSTVKHDG-----FYVNRGKLE 164 thale cress
XP_004249852     119 sDDEEDLNDFPDDDEYDTEDSFID------------DTE---LDEYFQVD----NSAIKHDG-----FFVNRGKLE 170 tomato
XP_006679245     171 KPVKKTTNVADAECNYDLEDDFID------------DSE---MFTDAMEGv--eEVPEWDFG-----YFVWHGSVE 224 Batrachochytriu...
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