Conserved Protein Domain Family
CRT10

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pfam08728: CRT10 
CRT10
CRT10 is a transcriptional regulator of ribonucleotide reductase (RNR) genes. RNR catalyzes the rate limiting step in dNTP synthesis. Mutations in CRT10 have been shown to enhance hydroxyurea resistance.
Statistics
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PSSM-Id: 400874
View PSSM: pfam08728
Aligned: 7 rows
Threshold Bit Score: 542.151
Threshold Setting Gi: 74607105
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q759E8    127 ISPAHTLLPQWERLNIkeegiTEDIFDFRH-----GCA------------FDNNLMCTSe----NSVLFIALGYEFRVFD 185  Eremothecium goss...
Q6FWJ3    108 HQPADNLLPSDMKLCV-----NFTVRKYVSrksveGFG------------FKNNLMQIF-----GDYIIIGRSSTVEIHN 165  [Candida] glabrata
Q6CUM3    106 CDPGEILLPNYYQIKVre-igSYPVHVFQHrs------------------gcNNFIILQn----RYALYISSVRTIKIVD 162  Kluyveromyces lactis
Q6CAP7     67 EAPSDFLPSQQMATMFdkeatTrv----------qFMGdstvgvmgeisqFKGNLAVEAt---rWPVLFIACGTHIEMFA 133  Yarrowia lipolytica
EDK39330  502 KDPYRPGLTSVDTISFssvmkDSPSSKFRDglkvsFVDykrinqagaarkYKNNIAGIIkdsdgREFLVTACESCLVFHE 581  Meyerozyma guilli...
Q6BNR5    282 YDPHRSEFTAIEDSDPtklviLPPAQKFRDliqlePLGvkklmgldnvrkYKNNISATIsdsegNNFLVTCANSDIVIFD 361  Debaryomyces hans...
ABN67500  175 IDAFSKDYTTIENTDPsrilrKPLAEMYKDglrlkHIGirklhalenirrFKNNISTIIndsdgRDYLVLASNSELIIFD 254  Scheffersomyces s...
Q759E8    186 LTKVDLSADtkhqs--rafnlLDSYLLYSAIPLPDTgFLSQVP-MDYRIHFI-KACSFYGDEYVAMCCESGYIMMF---- 257  Eremothecium goss...
Q6FWJ3    166 RACLTAASKlfylklsdwsahIDETTMTEQLKIPDA-FISTNL-MDVTINYM-KILEIKGGFYLCLCCDSGIVLFYslat 242  [Candida] glabrata
Q6CUM3    163 LTHLST---------------HNEILDAEQNLLIDD-LFTNSS-NEYTLSLMeRLPSFMGVTVLVFGDSAGNVSFYress 225  Kluyveromyces lactis
Q6CAP7    134 ADGSPDLV-------------GAFYAEPNIVTTEMR-EGAVRPnSPHDINML-SMVILCGHECLVANYDDGRSGLWvvsr 198  Yarrowia lipolytica
EDK39330  582 FDPLTQHPQte--------vcFAFETKPSYTTAWDR-LVSTSPeNPHTINYLkVYDNWLGQQVLAVCIDDGMVLMWytst 652  Meyerozyma guilli...
Q6BNR5    362 FDSISQLPNhl--------pvFRFDTKPTFTSTTDR-LISTWPyFPHTINFL-KTDTWLGKQILGACLDDGTLMIWyvet 431  Debaryomyces hans...
ABN67500  255 FDDVVALPNkk--------svLRFDTRPPFTSTTDR-LISTWPyFPHTVNFIrTFNNFCGRQVLGACIDDGSLMLWytdt 325  Scheffersomyces s...
Q759E8    258 LVrdfkAYd--------aSDDID-H---FGR---PTMQPR---YILEAAG---SCWAFDIYdDH-----PDIKIIAAGHN 311  Eremothecium goss...
Q6FWJ3    243 IV----MF----------IEDNK-Hg--TSR---IEIAPY---MVLRTPV---SCWSADSI-DY-----DGRTYIALGHN 290  [Candida] glabrata
Q6CUM3    226 FItsfsAV------------------------------PDkavLNLRLPSertKVLSCDYV--------DQSSNLTIFSS 267  Kluyveromyces lactis
Q6CAP7    199 IIaevqEG--------------------VSR-----YLPH---VTFKSDA---SVWGTG----------TSGSLLALSDN 237  Yarrowia lipolytica
EDK39330  653 ITeqmsKHrqr----frgSVNLD-Em--ERAiysVKIKPD---FKIRLKK---SAWGIDLS-TYtdslgDTHHVIVTSDN 718  Meyerozyma guilli...
Q6BNR5    432 ITeqltKFgltknnkvdnESELDnSytdQNRfygIKINPD---FKLKMEA---SLWGLDFL-SYeddggNMHNLIIASDN 504  Debaryomyces hans...
ABN67500  326 IIkyikSMkire--kvgrQDDADsLyrdTNRfhgLRVNPD---FKFKLEA---SVWGLDFL-NYndtfgNSHNLIVASDN 396  Scheffersomyces s...
Q759E8    312 AgsapTGITL--FAHYKD--CTRFAIE-----EIT--------------TEHNVPCVNFIKNT--SP-GFdITLAYTCIY 365  Eremothecium goss...
Q6FWJ3    291 G----PGISL--FVISYD--EDNVVVGpvhckEVI--------------TVHNVPCLSFIPGEtnTD-GS-LLLVYASIF 346  [Candida] glabrata
Q6CUM3    268 K----EVLTV--LFFDS---KERTPISd----EIT--------------FPASLSCITFLDCTvnGF-----IVICEDRT 315  Kluyveromyces lactis
Q6CAP7    238 S----RKIDIydLASLADklQEKHYVDrvnlySDEgveqvqlpryrsplMMNNIPSISIVVDEddAF-----YVTAGTIG 308  Yarrowia lipolytica
EDK39330  719 S----QTITL--LYYHVG--DQQFYSEe----SKQ--------------TSHNIPEVSFIRFYdnDG-LHyVFVAAASIS 771  Meyerozyma guilli...
Q6BNR5    505 S----QSIVL--FYYHVQ--DERFYHIk----SHQ--------------VLHNIPEVSFLSSHiqDE-IHkIKVACASIS 557  Debaryomyces hans...
ABN67500  397 S----QSVTL--FYYHQQ--DSRFYHVk----SHQ--------------ILHNIPEVSFVSHEvsNEgCHlVKVSCACIS 450  Scheffersomyces s...
Q759E8    366 GSVGTIRIQpflYMERDGatd----------------------------------------------kiKIPWEYWDEQY 399  Eremothecium goss...
Q6FWJ3    347 GNLTSLAIK---FDQTNN---------------------------------------------------DIDVSMKDTQF 372  [Candida] glabrata
Q6CUM3    316 ATKFTLHFPiktLQSGQIyy-----------------------------------------------elLEDSKAIDSHG 348  Kluyveromyces lactis
Q6CAP7    309 YEVATIKF----FTGERLekwkqsysemdirpfsrslss---------esldsivdaadeswedshiykPFEGGIWIHRN 375  Yarrowia lipolytica
EDK39330  772 AELVTFGFM---FYIQRGplslahdelsgkthitnvqpsy--------hvmgdveaplaprirsslerlDLVAIMLINRT 840  Meyerozyma guilli...
Q6BNR5    558 GELIIFKFN---FKLNDGpldrdeyeyfrneviyyvdatmaqiesrrenrpseedlretelrmkrfhrvLFNSPTVVSRV 634  Debaryomyces hans...
ABN67500  451 GELLIFQFE---FRIKSGpldqdeyeyfkketiyyidstme------ihnrdpnlensdeiklkkfkriSFLLPRVLTRT 521  Scheffersomyces s...
Q759E8    400 F-TSWCWTITPVSRKDFHRTTAYEYLTNTyDQEQKKKDLELIYQGSLILDSFPSiPSHSPIMGIAANMAQLFVPVSRLDP 478  Eremothecium goss...
Q6FWJ3    373 F-GEFCWTVTPLTSADFMEVSAYEFLNLNyQKVSKVSTLSSMCQDSQILGNSPSnCYKTKSFGIGALTTQVKVPVSQLEL 451  [Candida] glabrata
Q6CUM3    349 LcSHDESTLISISKDDFLSVPKYEFLTLSyNTSRNEETVRQIYQNSMILEVLPLyPSESNYLGFGASIAQIEVPIPNFSL 428  Kluyveromyces lactis
Q6CAP7    376 SlGTHVWTVTTVSPRAFKQSPTLYEVHAN-KWANEQQVAAQLQRDSSKAKNIFD---PLRPFYPAVRFTHYDIPTCPLQS 451  Yarrowia lipolytica
EDK39330  841 ElPEDSWTVKVIDPRWFLPVQSLRAMTGD-PSIREEKEITRIMNESRLLNGQCD-PLQTSFLGLAAEYQFYETPVVDI-- 916  Meyerozyma guilli...
Q6BNR5    635 LlGEDCWTCKPISSNAFKQVQSVRAMTGD-HRINEEQEIQHIMNESEILDFQYD-PLKTSHLGLSARWQFFESPVLTL-- 710  Debaryomyces hans...
ABN67500  522 VfGEDCWTTKPISSTYFNEVDSLAVAIGD-PFLREEKIVKSIMNESAALDL--------DHLGFGANWQFFQSRVVSI-- 590  Scheffersomyces s...
Q759E8    479 F--NGYQCMDGimefhfac---------------aqllngdGDIIpyRKARIKSNCMTYN-DEDSCMYFVPR---SDLPL 537  Eremothecium goss...
Q6FWJ3    452 S--CRYGMVNLpvklrfttfdnegfiqearllpnyisgippGGTI--EFFLHNNTEVQYKvDVQSAQKEKVRfnyAFPAL 527  [Candida] glabrata
Q6CUM3    429 LyrNDESLVNCpielry-------------------tayqkYGKHyhEVYVNKKVLNESFsQDPDCYISKRShgyGDSKV 489  Kluyveromyces lactis
Q6CAP7    452 GgiQPSGVQAL------------------------------AGMFpaMGVPTPGFNYKPHyLLPQCKKETRKmtqWYERY 501  Yarrowia lipolytica
EDK39330      --------------------------------------------------------------------------------      Meyerozyma guilli...
Q6BNR5        --------------------------------------------------------------------------------      Debaryomyces hans...
ABN67500      --------------------------------------------------------------------------------      Scheffersomyces s...
Q759E8    538 GDEKL--DkgvqesdlrrnmdfvttsrtiqkeyvdallrlKVKEPSSRSQQEPfylsfdeqpmlekkpnsvhlirhlhgp 615  Eremothecium goss...
Q6FWJ3    528 SSETLyeDierriekvldsttld--nnlnsrqndgfsqlfKVRQKSQIWGEKNglkyqynrnylttiynshdleelsqpf 605  [Candida] glabrata
Q6CUM3    490 GKVHVtsDr------------------------------sDVRQTRIGWEIVSdaeldfckdykdkflslqdqvetlrie 539  Kluyveromyces lactis
Q6CAP7    502 GIERVedNa------------------------------kNSASSAQSWSDEG--------------------------- 524  Yarrowia lipolytica
EDK39330  917 ----------------------------------------EGKEAE---QEDK--------------------------- 926  Meyerozyma guilli...
Q6BNR5    711 ----------------------------------------TTKLTE---NQDS--------------------------- 720  Debaryomyces hans...
ABN67500  591 ----------------------------------------SSETTA---D------------------------------ 597  Scheffersomyces s...
Q759E8    616 eeslnnnlagsslyrnpaiqrlhprevtrywmsndsfwgqkieiepspriepltlQASTPRPSTHGEDSGSNEGAFPlag 695  Eremothecium goss...
Q6FWJ3    606 sqv----------------------sndyvvlcassvfhsgyrgswkdiapyninEITSTENEEIPEDHKFLHPSLSlas 663  [Candida] glabrata
Q6CUM3    540 rkgypcf--------------dlqfidniecsadllrriyfhktwkftqiksselKSGEFSPSNIKDCFTARQLDIPiln 605  Kluyveromyces lactis
Q6CAP7    525 -------------------------------------------------------DSEQTKLSDTDEGAQEPPSDAP--- 546  Yarrowia lipolytica
EDK39330  927 -------------------------------------------------------EKESARVYSIDEEY----------- 940  Meyerozyma guilli...
Q6BNR5    721 -------------------------------------------------------TLESAKLTGVDDDY----------- 734  Debaryomyces hans...
ABN67500  598 -------------------------------------------------------LYKAGRITGIDDEY----------- 611  Scheffersomyces s...
Q759E8    696 ernrtlcddivdASLTNHIKKLYRLFSSLQKESRHKAEGPEFDS------VvsQDYMFVITTNTSVYLVRSDPLIVNALT 769  Eremothecium goss...
Q6FWJ3    664 aqe----gnqrkWGIHNHVKKVHDLLNCIEPNTRNYPMGYKLKE------F--HSGFLLVTTAQKVYLVKTHPMLILSYT 731  [Candida] glabrata
Q6CUM3    606 r--------idkDAVDEYVDKSIIKYLRICDESRFNNDGPKFFSk-----TsgSNFIFEATSTFETSLLGTDPIIMNAFT 672  Kluyveromyces lactis
Q6CAP7    547 ------------NSLYEH---------EVEREKKESPL---------------KDLFVIVTTHRSLYLCRHDDLFVNGAC 590  Yarrowia lipolytica
EDK39330  941 ------------QRIHKSMKKFHDDWAEEPI---QSVNGKWYLKlssflkIgkLAPILAMTTEHRACLFSSQTLICYGAT 1005 Meyerozyma guilli...
Q6BNR5    735 ------------RRIHKGIDNFVCNQQQKYISKKKSLNGKSYWPl-----DepSINMLAVSTSKKLGLFRADTLYCNSST 797  Debaryomyces hans...
ABN67500  612 ------------RRIHKGIQ------------------------------DleSENFLVVSTTKKLALFRADTLFCTCAT 649  Scheffersomyces s...
Q759E8    770 MdELFPTKD-VTTCQPAIEh--lNRISIVCYIRELSCIVVASQIGLLSVLRLTEYNGIYSFRQEYVIGwehippekrdti 846  Eremothecium goss...
Q6FWJ3    732 SdEIFPLES-ITLCSFKGTimalNRINFVCHIKEMNCIAVASQVGLISLLRLTKYKGIHSFRQEYILGwntlgpenddef 810  [Candida] glabrata
Q6CUM3    673 R-PIFPL---NFNCVDLSS----NKI-MVCHLREINCIVVANGSGLMFLYRLTEWRGIYAFRFEKILNilriqdicddsd 743  Kluyveromyces lactis
Q6CAP7    591 A-NVFSWED-IYGFGEQQF----DRLSFAHYIPDLCVYICGSPIGAVSVFRLTQKAGVFCMRQEWAFP------------ 652  Yarrowia lipolytica
EDK39330 1006 R-RIFNLSKhPRTHIDDAS----ARLSISHVIPELSCFIVISQQGLASIFRLCKHRGVYGMRQEHILP------------ 1068 Meyerozyma guilli...
Q6BNR5    798 K-KLFNLSI-PFSDESKFS----NRISITHIIPALLCFIAVTQQGLISIMRLCQHRGLFGMRQEHIFP------------ 859  Debaryomyces hans...
ABN67500  650 K-RVFDLAI-PFNEEVKFS----NRMSITCVIPKLSCIIAVSQLGLATIMRLCCSRGVYAMRQEHIFP------------ 711  Scheffersomyces s...
Q759E8    847 cms--------qyttgpqddsavpcGHCNTVFPSFLIQGLDYVYV--------------PDDPGNGILEHALLYVAYRNN 904  Eremothecium goss...
Q6FWJ3    811 qc----------iysklhgstnvycGIDDIDFPFLEINGMDYIYC--------------PRDDVKGVAEYAYLIVSFGSD 866  [Candida] glabrata
Q6CUM3    744 deerstfcetnrrftqnnsdfhhtcNECRLVIKYPMVQSMDYIHM--------------PETNA------VLLYVCTTAC 803  Kluyveromyces lactis
Q6CAP7    653 -------------------------DTSQILFFTDRLRLLAGVAVapihtsirenvigsRERQWNEPCLRYRVTLIYGDG 707  Yarrowia lipolytica
EDK39330 1069 -------------------------SARSLSEIYAGGKTICGLAV--------------RRASAAVEDPRYLIYITYTDG 1109 Meyerozyma guilli...
Q6BNR5    860 -------------------------NALSLALGSRGYRTIAGLAI--------------RDMSL-PKFPRYFIYVTYTDG 899  Debaryomyces hans...
ABN67500  712 -------------------------NALGLALGYNGYRTISGLAV--------------REKSILPRVTRYFVYLSYTDG 752  Scheffersomyces s...
Q759E8    905 LA-RYSI 910  Eremothecium gossypii
Q6FWJ3    867 IA-KFKI 872  [Candida] glabrata
Q6CUM3    804 LV-VYEI 809  Kluyveromyces lactis
Q6CAP7    708 YRiNYEI 714  Yarrowia lipolytica
EDK39330 1110 LViTYEL 1116 Meyerozyma guilliermondii ATCC 6260
Q6BNR5    900 IIvAYKL 906  Debaryomyces hansenii
ABN67500  753 IVvAYDL 759  Scheffersomyces stipitis CBS 6054
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