5X9Z


Conserved Protein Domain Family
Ins145_P3_rec

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pfam08709: Ins145_P3_rec 
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Inositol 1,4,5-trisphosphate/ryanodine receptor
This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.
Statistics
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PSSM-Id: 400861
View PSSM: pfam08709
Aligned: 9 rows
Threshold Bit Score: 266.659
Threshold Setting Gi: 122021144
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5X9Z_B          4 KMSSFLHIGDICSLYAEGSTN-----GFISTLGLVDDRCVVQPEAGDLNNP---PK-KFRDCLFKL-CPMNRYSAQKQFW 73   house mouse
Q9Y0A1         78 GNNGNLHIGDIISLYTESSSNqe-qrGFLSTLGLVDDRCIVELKDGRPESP---PK-KFRDCLFKV-CPVNRYAAQKHLW 151  Caenorhabditi...
Q14573          3 EMSSFLHIGDIVSLYAEGSVN-----GFISTLGLVDDRCVVEPAAGDLDNP---PK-KFRDCLFKV-CPMNRYSAQKQYW 72   human
Q5TQX0          4 GSVSFLHLGDIVSLYSEGSVS-----GFLSTLGLVDDRVVVCPGAGDLNEP---PE-KFRDCLIKI-CPMNRYSAQKQFW 73   Anopheles gam...
EDO37876        3 QVTSFLHIGDIVSLYAEGNVT-----GFISTLGLIDDRCVVQPGAGDLSNP---PK-KFRDCLFKI-CPMNRYSAQKQFW 72   starlet sea a...
Q24498         11 DDVSFLRTEDMVTLSCTATge----rVCLAAEGFGNRHCFLENIAD-KNVP---P--DLSQCVFVI-EQALSVRALQELV 79   fruit fly
XP_011609906    9 eEIQFLRTGDHVVLQCTASILkeqikVCLSCEGFGNRLCFLETTSNAQSVP---P--DLAICCFIL-EQSLSVRALQEML 82   torafugu
Q4DBL7          3 RKQRIIKYGSLVHFSCEE--------GYIAASGLEAEDLFIREKNDTDIDEeplPLlGFETSVFRIeAPASSLAAKAQEA 74   Trypanosoma c...
Q57XB2          3 QSRVPIRYGAFIHLSCDE--------GYVTAGGLGNEGLFIRNKNELSDDAeplPLfGFETSVFQIlPPTVAKVAAEEGL 74   Trypanosoma b...
5X9Z_B         74 KA--AKPGANSTTDAvllnkLHHAADLEKKQNetenrkllgtvIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTL 151  house mouse
Q9Y0A1        152 TEqkRFQTGDSMFDDdlmnkLKVAADKEREENesefqktlgnvIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYL 231  Caenorhabditi...
Q14573         73 KAkqTKQDKEKIADVvllqkLQHAAQMEQKQNdtenkkvhgdvVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTL 152  human
Q5TQX0         74 KA--AKQSTTTNTDTsllkrLHHAAEIEKKQNesenkkllgtvVQYGSVVQLLHLKSNKYVTVNIRLPALLEKNAMRVYL 151  Anopheles gam...
EDO37876       73 KA--AKP-TTSATDAvllkkLHHAAELEKKQNeseykkmlssvVQYGSVMQLLHVKSNKFLTVNKRLPALREKNAMRVTL 149  starlet sea a...
Q24498         80 TAa-GSETGKG--------------TGSGHRT-----------LLYGNAILLRHHNSDMYLACLSTS-SSNDKLSFDVGL 132  fruit fly
XP_011609906   83 SNtsLDE----AVDL-----DKWSSQGGGHRT-----------LLYGHAILLRHTHSSMYLSCLTTSRSLTDKLAFDVGL 142  torafugu
Q4DBL7         75 VAdrFSNNNTLLME--------HFSNINTAPE-----------LMYGKPFLLLHSVSQMCVAVFPSKPSKSDPNCVRLVL 135  Trypanosoma c...
Q57XB2         75 SKgnRAPNSNPLSD--------GVSNIYSTQQ-----------VTFGQLFVLVHAVSRLHVAALPSEPSERDPDCARLVL 135  Trypanosoma b...
5X9Z_B        152 DEAGN-EG--SWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAG-------QP-LH-ASSHQLVDNPGcNEVNSVNCNTSWK 219  house mouse
Q9Y0A1        232 DRAGN-EG--SWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSttqaghvKSqLH-LSSFNLLDHQSaAEVNCLNEPTEWQ 307  Caenorhabditi...
Q14573        153 DATGN-EG--SWLFIQPFWKLRSNGDNVVVGDKVILNPVNAG-------QP-LH-ASNYELSDNAGcKEVNSVNCNTSWK 220  human
Q5TQX0        152 DANGN-EG--SWFYIMPFYKLRSAGDNVVVSDKVILKPVNAN-------RQnLHvAVTYELPDNPGsKEVNVLNSSTSWK 221  Anopheles gam...
EDO37876      150 DPNGN-EG--SWFYIVPFYKLRAAGDNVVVGDMVILNPVNAG-------QP-LH-ASNQELIDNPGcKEVNCVNCQTSWK 217  starlet sea a...
Q24498        133 QEHSQgEA--CWWTVHPASKQRSEGEKVRVGDDLILVSVATE-------RY-LHtT-----KENEQ-SIVNASFHVTHWS 196  fruit fly
XP_011609906  143 QEDSTgEA--CWWTIHPASKQRSEGEKVRVGDDLILVSVSSE-------RY-LHlS-----YASGD-LMVDASFMQTLWT 206  torafugu
Q4DBL7        136 VKAGEvESdfCEFVVTPRYKIHDDGDPVCRGDEVLLRLAAFP-------IF-VHvTGR-------------KHPGLNTWG 194  Trypanosoma c...
Q57XB2        136 APPGEiEQtfCQFIFTPRYTTHGEGDVVCRGDEVLVQLSSIP-------IF-LQtTVVSPTRPVKH-----ETFGSASFP 202  Trypanosoma b...
5X9Z_B        220 IVLFMKWSDN 229  house mouse
Q9Y0A1        308 VFMFLLFDEN 317  Caenorhabditis elegans
Q14573        221 INLFMQFRDH 230  human
Q5TQX0        222 ITLFMEQREN 231  Anopheles gambiae str. PEST
EDO37876      218 ISLFLSYDEN 227  starlet sea anemone
Q24498        197 VQPYGTGISR 206  fruit fly
XP_011609906  207 MTPVMSGCEl 216  torafugu
Q4DBL7        195 MPSEEDGCDS 204  Trypanosoma cruzi
Q57XB2        203 YEPTDGCGRG 212  Trypanosoma brucei
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