Conserved Protein Domain Family
Vps51

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pfam08700: Vps51 
Vps51/Vps67
This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues.
Statistics
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PSSM-Id: 400855
View PSSM: pfam08700
Aligned: 46 rows
Threshold Bit Score: 41.4913
Threshold Setting Gi: 74606609
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7S488        247 LDSPDFSAQPYLA-ELLQSSTLAELLKTYARILSEIRALDAEKKALVYDNYSKLISATETIRKMRTSMfdpnaltgDKLD 325  Neurospora cr...
Q9UTL1          7 MSSHSSNWKEIFR-----THSIAQTIQLEKFVSQQIEEKGRELQQNVCFNYQSFIEASENLSNIRNNL--------EKVL 73   Schizosacchar...
Q7RZT4          9 LSTLLSSAQIFSS-----NYPLPHIRAIHKALHAEIDDKQSRLRTQVGGSYRELLGTADTIVQMRGDM--------ESVQ 75   Neurospora cr...
Q2U987          1 MALDGPDPQSLNSwQDAFQYPIPTVRRVEQELRRDIASNKEKLRALVGTRYRELVGTAETIVSMNREM--------QEVD 72   Aspergillus o...
Q6C0N6         24 MALGLSSWQSTMS-----KYSIADVVIIEQQLRSKKDRRNEELRCLINTTYRDLLGTTDDIQSLSEKM--------TKQH 90   Yarrowia lipo...
XP_001276848    6 NVNINEDPRLLFE-----KYDVATIKKIKESAQTEIEHKQNVLRQFIGDNYKPVLETPPVLKDIQVIF--------EDTR 72   Trichomonas v...
XP_011387543   79 FDPFGTEPDTLFL-----SLTVKEVEAYERAVRSTALGKQEELRSLVGQRYEDLLGTANTIIDMAGSS--------SGLS 145  Ustilago mayd...
Q6BJZ0         17 IINEDTSIDDIFT-----HLTIQQIQKLNKNYKQNVTNAKEDLHGLVGNKYRDLIKIAEDISNMYVVT--------SEVD 83   Debaryomyces ...
Q4E335          3 SEEAVQEVRRIFT-----NNTVEQVRDYLSTITRGIQESDYRLKQIVGQSYRDLIAACDKVVGMEQTC--------RKLL 69   Trypanosoma c...
CBZ11904        3 MEEAAQEVRRILC-----QNDVEETLNYLSTVTRCIEDNQHDLRAVIGNSYRDLLGACDGVVGMERDC------------ 65   Leishmania ma...
Q7S488        326 PMASTLDAVLGKVYE 340  Neurospora crassa
Q9UTL1         74 QNSYEFQSMVSLPKV 88   Schizosaccharomyces pombe 972h-
Q7RZT4         76 ATLGRMGGRCGRQVV 90   Neurospora crassa
Q2U987         73 ATLADIGRRCNPRLM 87   Aspergillus oryzae
Q6C0N6         91 TLLSNLSHG----DI 101  Yarrowia lipolytica
XP_001276848   73 QTLSKITEYSKNFNS 87   Trichomonas vaginalis G3
XP_011387543  146 HRLLELLSRVRLAAA 160  Ustilago maydis 521
Q6BJZ0         84 QKLSDLSYGQSRFVS 98   Debaryomyces hansenii
Q4E335         70 QMQKQLHTEQQLTLS 84   Trypanosoma cruzi
CBZ11904       66 ADILTIEEAMERASA 80   Leishmania major strain Friedlin
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