5EAN


Conserved Protein Domain Family
Dna2

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pfam08696: Dna2 
DNA replication factor Dna2
Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, ( 5'-flap endonuclease) and helicase activities. It is required for Okazaki fragment processing and is involved in DNA repair pathways.
Statistics
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PSSM-Id: 400852
View PSSM: pfam08696
Aligned: 131 rows
Threshold Bit Score: 118.04
Threshold Setting Gi: 573481236
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5EAN_A                   75 SQDREHEVLCILRNGW-SSVP-VEPGDIVHLegdc------------tsePWIIDD--DF------------G-YFILYP 125 
3_pfamImport              1 KDKDGKIRMVYLQDIW-SEVP-VEEGNKINLiaakk----------weedDFIVDD--EQ------------G-IVILNP 53  
Q9U3F2                  122 IDKEGTTRIVYLQDHW-SEMS-IEAGSTINLigaqa----------wgdrDFLVND--DV------------G-IVILNP 174  Cae...
EFO86185                129 VDKNGKTRLVYLQDRW-SELD-IEVGNTINLigpek----------wgddDYIAND--TK------------G-IVILNP 181  Cae...
CAP23520                147 VDKQRKTRVIYLQDQW-AELD-VEVGNAINLiapqv----------wgndDYIVNN--QK------------G-IVILNP 199  Cae...
EFX65778                 37 DETYKTKKICMLRDFW-LDTA-IKVGDDVHIhadwyesfd---enfenydlaIVDR--QS------------G-LIVVKP 96   com...
XP_649299                37 EQQEKKQFILYLDDLW-YETS-LKVGDFIHLifleertk------nslpnpfILNN--RT------------PiLLIQNP 94   Ent...
A0BNB9                   97 fgdNQKTIEIFLFDHY-NNLKqIRKGMQIRVngefi-----------dsraIIFTQkiQN------------KnSFTLEP 152  Par...
PRJNA71415:HALLA_13505   56 svdGKDARTVTLWGKWtESAAlLEPG--IEL---------------------LVTNveEDeyqgetqysttgDsYVVVEP 112  Hal...
EAX95406                 79 pglghSERYVHLRGQW-ATSS-ISIADPCFIvgkwelgddpvgnvyqnkyYTIIDD--AN------------G-FFISLP 141  Tri...
5EAN_A                  126 DMMISGTSVASSIRCLRRAVLSETF--RGSDPATRQMLIGTILHEVFQKAI------Se----------------sFAPE 181 
3_pfamImport             54 NALVPCTAVASASWCMRKTVLNERF--KFGNASNKAMLLGTIMHEIFQSAI------Is-----------------KKRP 108 
Q9U3F2                  175 DALVPCTAVASATFCARKTVLNDKF--KFGNASNKAMLLGTIMHEIFQTAI------Ts-----------------KKRP 229  Cae...
EFO86185                182 NALVPCTAVASSLFCSRKVILNDKF--KFGNASNKAMLLGTIIHEIFQTAI------Ts-----------------KKRP 236  Cae...
CAP23520                200 NALVSCTAVASATFCARKTILNEKF--KFGNASNKAMLLGNIVHEIFQTAI------Tn-----------------KKRP 254  Cae...
EFX65778                 97 DLLVSGTSVVSSLFCQRKAVLSERF--RGIEPTNQVMLNGTIVHRLLQKAL------Iek---------------tYDTS 153  com...
XP_649299                95 DYLINTTSTVSSTWCNRQTVIKNYL---FLDDYYEATTLGTIIHGTIQHILi-----Tnp--------------peFNKT 152  Ent...
A0BNB9                  153 ETLVAPSILNGLDFCRRKQFTREFFqnQCFG-TTLEMLSGKILHDFFQNIImdvksyDslfenieqldehqkdlqqLVVE 231  Par...
PRJNA71415:HALLA_13505  113 SFLVNVTAVRNWVECPRLYYLNKLSgv----pLNYPVVKGTIVHEVFGDLL--------------------------RGR 162  Hal...
EAX95406                142 HVLISGTEMATAQRCRRQTYINSVCpeRI---SNMDMFRGSICHILLQRVF------Fg-----------------LRNQ 195  Tri...
5EAN_A                  182 RLQELALQTLRe--vRHLKEMYRLNLS-QDEILCEVEEYLPSFSKWAEDFMRKGPSSEFPQMqlslpsdgSNRSsp---- 254 
3_pfamImport            109 IVESDLLKIWStqapKYAEELVALSFT-PNCLISELEPYFSIISEWINKHYPISNSFFRKKE--------PLPS------ 173 
Q9U3F2                  230 VMENDLMKIWNkqapKYAEELVALSFT-PSCLDAELQPYFSIICGWINKHYPLSNSFFSKRE--------PLPS------ 294  Cae...
EFO86185                237 LVEDNLLQIWNtqapKYAEELVALSFT-PSCLNVELKPYFSVICDWINKHYPLSNSFFTKRE--------QLPS------ 301  Cae...
CAP23520                255 LVDSDLLKIWTtqapKYAEDLVALSFT-PTCLDAELQPYFSVICNWINKHYPTSTGLFTKRE--------PLPS------ 319  Cae...
EFX65778                154 SLNKIADKLLSd--pSTIHDLYGANIP-KSNLKNSVSEYIPMIKNFIDKYINATRPCEVSKR--------DNRQqvvgks 222  com...
XP_649299               153 IFKSMIEELSE----ELLTKVYVLGIT-RKEFIDHAMEFYDTVNNWYQCWKTKTIKTNLNR------------------- 208  Ent...
A0BNB9                  232 NLPQSFLQPISqlysKYIQEFYHLEKKtVREMLINIIPKCVNTLRWIQQFVIKQQPISLKQQ--------KSSDv----- 298  Par...
PRJNA71415:HALLA_13505  163 DLEAAIDERID----ERGLELGLLGET-PEAVAEDVRDNAAAIEGWLEQGRLTEEDGAATAA--------DNPEraf--- 226  Hal...
EAX95406                196 DIDHTLDQLLE----SSKYELFLMEET-KESAKSTIIPYLETIRLIADAIETNSN------------------------- 245  Tri...
5EAN_A                  255 ---------cNIEV-------------------VKSLDIEESIWSPRFGLKGKIDVTVGV 286 
3_pfamImport            174 ----------KSVL-------------------LEVHDIEENIWDSRLGLKGKVDVTMRT 204 
Q9U3F2                  295 ----------KSEL-------------------LEVYDIEENIWDSKLGLKGKIDVTMRT 325  Caenorhabditis elegans
EFO86185                302 ----------KSEL-------------------LEVYDIEENIWDSKLGLKGKVDVTMRT 332  Caenorhabditis remanei
CAP23520                320 ----------KSQL-------------------LEVHDIEENIWDSKLGLKGKVDVTMRT 350  Caenorhabditis briggsae
EFX65778                223 rkfgssptmwDGQI-------------------DSVCDIEENMWSPWLGIKGKVndkklg 263  common water flea
XP_649299               209 ----------EIHF-------------------SEFIASEPQIQSQIFGFKGAIDILlnd 239  Entamoeba histolytica H...
A0BNB9                  299 ---------fKIKI-------------------LKWVSNEQLISSSVYGLKGFIDVVVQV 330  Paramecium tetraurelia
PRJNA71415:HALLA_13505  227 ------------------------------tpaEGSWRSEQLLISETFGIRGRADAVRRg 256  Halostagnicola larsenii...
EAX95406                246 ----------KFTLdhrlfngiatpiealppygAKTVQEEENIWSFQWGLKGKIDATMEk 295  Trichomonas vaginalis G3
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