Conserved Protein Domain Family
ASD1

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pfam08688: ASD1 
Apx/Shroom domain ASD1
This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure. ASD1 has been implicated directly in F-actin binding.
Statistics
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PSSM-Id: 400846
View PSSM: pfam08688
Aligned: 40 rows
Threshold Bit Score: 151.344
Threshold Setting Gi: 1720725887
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013123993  877 ALQRSRSSFHLDGsKEEDSSKDFPWRQEIQei-maPMQDTSTNRSYRDSLKDAQSKVLRSTSFRRRDLTSsgsaqpppap 955  Nile tilapia
A2ALU4        662 KLQKSKSTVTLAG-DSEAEDCAGDWRADVG-----AVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDP---------- 725  house mouse
Q13796        640 KLQKSRSTVALTA-AGEAEDGTGRWRAGLGg----GTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDP---------- 704  human
XP_023395451  680 KLQKSKSTVTLAG-TDEPKEDPGGWRVELGav-tgATPEGSFTSTYKDHLKEVQARVLRATSFKRRDLDP---------- 747  African savan...
XP_007501006  701 KLQKSKSTATLTG-ANEEEEDADGWKAEAGenfsaSTAEGSFNNTYKDHLKEAQARVLRATSFKRRDLGP---------- 769  gray short-ta...
XP_022272026  595 KLQKSKSTVTLTG-SGDAAEEAGSWRAERGga-tsATPEGSFTGTYKDHLKEAQARVLRATSFKRRDLDP---------- 662  dog
XP_002930837  646 RLQKSKSTVTLPG-TGGAAEEASGWRAERGda-tgAAPEGSFPGTYREHVKEAQARVLRATSFKRRDLDP---------- 713  giant panda
XP_012915038  622 RLQQSKSTVALTG-AGGVAGEAAGWGMQHGaa-tsATPEGSFTGTYRDHVKEAQARVLRATSFKRRDLEP---------- 689  domestic ferret
ELK07552     1034 NLQKSRSSVTLAG-PYEAEGEAAGVRAGVRa----ATLEAALPGTYKDHLKEAQARVLRATSFKRRDLDP---------- 1098 black flying fox
XP_023356111  610 KLQKSRSTVTLTG-TNEEEEFADGWKPGSGqnfstTASEGSFNNTYKDHLKEAQARVLRATSFKRRDLEP---------- 678  Tasmanian devil
XP_013123993  956 PSVSSSGsQQPPPVP------PKYHSlekkgpttmpkprgivitpqSQPLVTSPHTPKERHvVTpdvrgpsppplPSVPP 1029 Nile tilapia
A2ALU4        726 TPADQYS-GPSEHRT------FDHSAsssl-------------ssfPGEPDSAPRFCETGL-AK-----------APSSG 773  house mouse
Q13796        705 NPGDLYP-ESLEHRM------GD--------------------------PDTVPHFWEAGL-AQ-----------PPSST 739  human
XP_023395451  748 SPGDHCP-VPPEHRP------GDRDTss----------------lyPLGLDAAPHFLEGDS-AK-----------LSLPG 792  African savan...
XP_007501006  770 SSADHYSkSSPERKA------NGYSSsf----------------llALDPDSASQFFDVSQ-TK-----------TSTSG 815  gray short-ta...
XP_022272026  663 SPADHHA-GSPEHRA------EEHS----------------------ADPDTAPHFWEGGL-AK-----------PPPSG 701  dog
XP_002930837  714 SPVDHYA-GSLEHRA------EEHG----------------------ADLDTVPLVREGGL-AK-----------PPPPG 752  giant panda
XP_012915038  690 SAADPYA-GSPEHRA------EDHG----------------------TGPDPVPRVWEGGS-AK-----------PSPSG 728  domestic ferret
ELK07552     1099 SPADRHA-ASLERRA------GDPH----------------------EHPGTASRVAKVGL-AR-----------SPSCA 1137 black flying fox
XP_023356111  679 SSSDHYSkSSPErktngysssssLT----------------------LDSDSASHFFDVSQ-TK-----------ASTSG 724  Tasmanian devil
XP_013123993 1030 VGQPALPRICGRKRLTADQKKRSYSEPENMNEVGISDPETvslfrrggE---------TSVADRRKMFE 1089 Nile tilapia
A2ALU4        774 VGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRph-----pTvrtp-edtvGTFADRWKFFE 836  house mouse
Q13796        740 SGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSph-----qHprts-edtvGTFADRWKFFE 802  human
XP_023395451  793 GGVPHILRIGGRRRFTAEQKLKSYSEPEKIHEVGLSGNYRph-----qVpnrv-edtvGTFADRRKFFE 855  African savanna elephant
XP_007501006  816 NGVQHVSRIGGRKRFTAEQKLKSYSEPEKINEVGISGDYHhp----chYpsts-geamGSFADRCKFFE 879  gray short-tailed opossum
XP_022272026  702 GGMPHVLRIGGRKRFTVEQKLKSYSEPEKMNEVGLSGDYRph-----qHpdaseetvvGTFADRWKFFE 765  dog
XP_002930837  753 AGVPHVPRIGGRKRFTLEQKLKSYSEPEKMNEVGLSGDERpp-----qHpgts-eetmGTFADRWKFFE 815  giant panda
XP_012915038  729 AGGPHVPRIGGRKRFTLEQKLKSYSEPEKMNEVGLSGHERpq-----qHpgts-detlGTFADRWKFFE 791  domestic ferret
ELK07552     1138 GGVSHVARIGGRKRLTAEQKLKSYSEPEKMNQVGLSGAHCpqpe-----------ekvGTFADRCKFFE 1195 black flying fox
XP_023356111  725 NGMLHVPRIGGRKRFTAEQKLKSYSEPEKIHEVGISGDLRhp----cqYpsta-geamGSFADRWKFFE 788  Tasmanian devil
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