Conserved Protein Domain Family
GON

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pfam08685: GON 
GON domain
The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.
Statistics
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PSSM-Id: 400843
View PSSM: pfam08685
Aligned: 39 rows
Threshold Bit Score: 194.732
Threshold Setting Gi: 674572326
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX81745             251 SCKDVQLRSAAAKdrktppaDGPYTLI--VAGK--NMTIYCHLMNTSSPLEYLTLTtGHQDNYAEVYDKTLIRPDSCPYQ 326  common...
CDS42751            1618 SCWDQKQRHPASS-------DGLYELA--VHRR--VVRIYCSDMESSYPREYLPL---HHLNYASIWHFKEAREQNCSST 1683 Echino...
Q7KSH7              1344 SCADLKEMHGYNK-------DGNYQLE--VRSR--MVHIYCHGMNSRTPQEYVNVD--PQENYSIYYEYRTKQTNSCPPE 1410 fruit fly
KRF83491            1455 TCADLQHMYRVYK-------DGEYTLQ--VHSR--QVRIYCHQMNSRTPREYITVE--PQENYSIYYEYKTRLIDSCPPT 1521 Drosop...
WGS:AAQB:GK11632-PB 1350 SCSDLQRINRVYE-------DGEYWLV--IRSR--QIRVYCYRMNSRTPSEYITVQ--PQENYSIYYENKTHRMDSCPTE 1416 Drosop...
Q177I1               847 TCHDIQRTRRTRH-------DGEYMLT--VKGQ--PVSIYCHNMSSNAPTEYLTLQsGLLENYAIYNNKRAEIAGVCSPS 915  yellow...
Q7QB38              1228 NCNDARRKHKT---------DGEYMMH--VNGT--KAKIYCHGMATDTPTEYLSLPaGPTENYAIYINRRAADANKCENS 1294 Anophe...
ETN67137            1201 NCKDAQSRHRT---------DGEYMIQ--VNGT--SVRIYCHGMATATPIEYLTLTsGPVENYAIYINRRAADANKCQVS 1267 Anophe...
EDO27330              47 SCAEIKKMWSGYQ-------DDEYTIQ--MSPQcePVRLFCHGMRTAKPQEYITLDsGPDKNYASFHRERLLNYESCSGK 117  starle...
XP_002612811         117 SCVEAKSLSSDTN-------DGEYILYpfATDSdvSIRIYCHGMASGEPKEFLTLPsGPDENYAVIFAGRMRYAYQCTGS 189  Florid...
EFX81745             327 GARKDSCdcFLNRRS-TGT-----------------TSFNKIRLNVTS--LRVDSHDFTFARLvRGhQMVGYGEAGDCYS 386  common...
CDS42751            1684 NVYYKGK--VTDTNVtSGTpseiqslellefpadsvTVFKKLHINLNS--LHVDIFDERFSET-LGtRFVPYASAKSCSR 1758 Echino...
Q7KSH7              1411 SRGHEYY-----NDQnSGR-----------------THFRKLRLNITD--LRIMDNDFKFADS-RG-LAQKLGSAGDCYN 1464 fruit fly
KRF83491            1522 SRDHEYA-----NDQnSGR-----------------THFSKLRLNISE--MRIIENDFEFAES-RG-QRQALGSAGDCYN 1575 Drosop...
WGS:AAQB:GK11632-PB 1417 SREHEYY-----NPEnSGR-----------------TYFSKLRLNVTN--LRIIENDFEFAET-RG-QRQKLGSSGDCYN 1470 Drosop...
Q177I1               916 SAD------RVDESIdYGA-----------------THYRKIRLNIHT--LQVLVDDHRFTDR-SG-KPQAFGSAGDCYS 968  yellow...
Q7QB38              1295 QRD------WADSSIsYGA-----------------THYRKIRINVST--LQVHTNDFRFTNS-SG-KKQPFGSAGDCYS 1347 Anophe...
ETN67137            1268 DRD------WTDETNsYGA-----------------THYRKIRLQLPT--LQVITNDFQFTNS-SG-KKQSFGSAGDCYS 1320 Anophe...
EDO27330             118 TNPSPQL-----TEKyWGT-----------------SRFNKIRIDPSS--GLIHRDDFTFSFH-TG-NPVKYGRAGDCFS 171  starle...
XP_002612811         190 ---------LQDPWAnRGT-----------------TKFSKLRIQFDTsrVKVIRNVYTFAQT-TGpNDVPYGKAADCYS 242  Florid...
EFX81745             387 TAN-CPQGRFSINLQGTGLRVSPHTSWAGHGHRSSLW--IN--RLEdnQKIQGKCGGYCGRCSPDPHAGLKLDV 455  common water...
CDS42751            1759 GTS--QLGKFLINLKGTGFTVSKETQWRTSRLQSFGH--VA--RTGdsMIVMGSCGGDCGGCWPDPllkleaad 1826 Echinococcus...
Q7KSH7              1465 RIGqCPQGDFSINMKDTDFSIRPGTVWRMHGQYSVMKriSE--FDTttQMRRGFCGGYCGGCYIAPDSGLYLDV 1536 fruit fly
KRF83491            1576 RNMnCPQGDFSISLERTGFAMRPGTVWNTYGSRSIMQ--RAsgFDTsaTSRRAFCGGFCGRCHISPTSGLYVEV 1647 Drosophila v...
WGS:AAQB:GK11632-PB 1471 RNMrCPQGDFSINIERTGFIIRPGTVWNKLGNRVVMHrtAG--FDTakFSRRAFCGGYCGSCSISSTAGLYLDV 1542 Drosophila w...
Q177I1               969 NTGrCPQGDFSINLENTPFRIRPRTQWETKGVNAVLNflIR--LEApyKKVRARCGGYCGICSVSRSTGLFLEL 1040 yellow fever...
Q7QB38              1348 NTGrCPQGDFAINLKGTPFRIRPHTSWEKSGVHAVIKflVP--LQPpyQKVRALCGGYCGSCSVSRRTNLYLEL 1419 Anopheles ga...
ETN67137            1321 NTGrCPQGDFAINLEGTPFRIRPRTVWKTNGVNAVIKflVS--LKPpyQKVRALCGGYCGSCSISSDTHLYLEL 1392 Anopheles da...
EDO27330             172 AASkCHKGRFNIDLTGTGLRVRSDIEWEQWGSPKIPHrlLSyrKSDdgTKVFGECGGSCGGCTP-KNERLYLEp 244  starlet sea ...
XP_002612811         243 AKQgCAKGTFKVNLTGTDLALAPEVHWVMGPHYPASLiiNDmfISEdrKVASARCGGWCGHCRPNGgeiyltps 316  Florida lanc...
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