1UGJ


Conserved Protein Domain Family
CAMSAP_CKK

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pfam08683: CAMSAP_CKK 
Microtubule-binding calmodulin-regulated spectrin-associated
This is the C-terminal domain of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal, or CKK, domain - defined as being present in CAMSAP, KIAA1078 and KIAA1543, The C-terminal domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved with the metazoa. The structure of a murine hypothetical protein from RIKEN cDNA has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.
Statistics
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PSSM-Id: 400841
View PSSM: pfam08683
Aligned: 19 rows
Threshold Bit Score: 148.581
Threshold Setting Gi: 255079754
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UGJ_A          8 PRLYKEPSAKSNKFIIHNALSHCCLAGKVNEPQKNRILEEIEKSKANHFLILFRDSSCQFRALYTLS-----------GE 76  
U4PAZ9        973 HKLYAKTVTKSNRGLINNALQFSVFPGAVNNATRQATITQMASSSSKHFLILFRDQKCQYRGLYTWD-----------EI 1041 Caenorhabditi...
XP_001638377 2759 PQCYVKPSGKSNRKLIVNAISYVCLSGTVNKDAKERCLQAISESNGYHFMVLFKD-GLKFRGLYSFN-----------PE 2826 starlet sea a...
XP_011673936 2002 PKLFVKPTSKSNRHIIINAISHCILAGVVNEKTKDKVLQEIAKADQKHFMILFRDHSLQFRSLYSFT-----------PE 2070 purple sea ur...
EKC40450     1629 PKLFVKPSSKSNRHIIINAISQCVLAGPVNSDQKNKVLEVLAKSDAKHFLILFRDHSCQFRGLYSFD-----------PD 1697 Pacific oyster
XP_015794640 1171 PKLYVKPTAKSNRGIITNAIN-VVLAGAVNANLKKKVLEEMNNSESKHFLILFRGAGMQFRAIYSYN-----------PD 1238 two-spotted s...
EEC02376     1368 PKLFVKPAAKSNRGIVLNALN-TVLAGQVNADTKRRVLEEMGVSDSKHFLILFRDAGCQFRGLYSYQ-----------PE 1435 black-legged ...
EFX79702        4 PRLYKQPAARSNRSIILNAVEYCVFPGVVNREAKQRVLEEITRSESKNFLVLFRDGGLTFRALYSFN-----------PE 72   common water ...
ESO03211     1327 PKLFVKPSSKSNRHLIENALSHCCLAGTVNQDNKAKVLEVLQRSESKHFVVLFRDVGMQYRGLYAYSttas----nggAD 1402 Helobdella ro...
ESO04191       16 PRLFVKPSSKSNKNIVENALSHCCLAGLVNQDVKCKALEALQKSSSKHFVVLFRDVGMQYRGLYAYNinhnipcsdigTR 95   Helobdella ro...
1UGJ_A         77 T-E--ELSRLAGYGPRTVTPAMVEGIYKYNSDRKRFTQI-PAKTMSMSVDAFTI 126 
U4PAZ9       1042 S-D--TAVKISGQGPPKCTEAMMNSMFKYDSGAKNFTNI-ATKHLSATIDGFAI 1091 Caenorhabditis elegans
XP_001638377 2827 N-E--QLYKVFGIGPRVITAKMIDNLYKYSSGGKEFVKI-HSKTLSISVDGLSI 2876 starlet sea anemone
XP_011673936 2071 S-E--ELTKVYGTGPRHITNKMTDTLYKYNSGGKHFAKV-PSKSLSVQIDGVTI 2120 purple sea urchin
EKC40450     1698 S-E--DSIKIHGIGPKQITSKMIERFYKYNSGGKSFSEVtSTKHLSVSIDAVVI 1748 Pacific oyster
XP_015794640 1239 ReDrqEIVKLHGNGPKIVTDDMIDKFYKYNCGGKNFNEV-QTKHLSVTIDAFTI 1291 two-spotted spider mite
EEC02376     1436 R-E--EVGRLFGVGPRTVTAPMMDLFFKYNSGAKSFSRI-HTKHLTVTIDAFTI 1485 black-legged tick
EFX79702       73 K-E--EIIKMYGTGPKLVNDTMFEKFFKYNSGGKCFSQV-HTKHLTVTIDAFTI 122  common water flea
ESO03211     1403 G-D--EIVKLHGVGPKIVTSKLIEKFFKYNSGSKTFSEVtSTKHLSATIDGITL 1453 Helobdella robusta
ESO04191       96 G-C--EIVRLHGVGPKVVEPKQIEKFFKYNSGAKNFFEVtSTKHLSATIDGVTL 146  Helobdella robusta
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