4J1Q


Conserved Protein Domain Family
KR

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pfam08659: KR 
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KR domain
This enzymatic domain is part of bacterial polyketide synthases and catalyzes the first step in the reductive modification of the beta-carbonyl centers in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.
Statistics
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PSSM-Id: 370044
View PSSM: pfam08659
Aligned: 52 rows
Threshold Bit Score: 150.017
Threshold Setting Gi: 81372808
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4J1Q_A    203 GVYLITGGAGSLGLLFAKEIAN----RtG-RSTIVLTGRSV--------------LSEDKEnELEALRSIGA----EVVY 259 
Q4KCD4   2749 GVYAITGGGGGLGLVFARQIAS----S-CrNPVLYLAGRSq--------------PSAAAQgMFEQLQALGA----RVVY 2805 Pseudomonas prote...
Q4KCD8   4831 GVYLITGGLGGVGTVLAREIRA----A-ApRARVVLCGRTp--------------ATAPs--VLAKLEQLGA----GVDY 4885 Pseudomonas prote...
Q63LK8   1909 GVYLVTGAAGGLARALADAIARgmggD-ApRATLVLTGRSp--------------ARDDMRaLVASLCALGV----AADY 1969 Burkholderia pseu...
Q4KCD7   2852 GVYLITGGAGGLGLIFARTIAE----Q-CrDVTLILLGRSh--------------LDSRQQaQLQAIRDLGA----AVVY 2908 Pseudomonas prote...
Q7N5R3   3549 GVYLITGGLGGIGQLLARHISN----Q-CsKVKLGILSRRg--------------TNAVSEaLLDVLQKSGA----EVMM 3605 Photorhabdus laum...
Q5YVB9   1741 GTYLITGGFGGFGLATARWLIG----K-G-ARRLMLVGRSGa-------------ATPAAKqQIAAWAALGV----TVLE 1797 Nocardia farcinica
BAC69262 3433 GVYLITGGLGGLGRVVAERLVR----R-G-ARRLALLSRGr--------------PGADAAgWIKGLEERGV----TVHL 3488 Streptomyces aver...
Q5YMZ6   1254 GTYVVTGGLGRLGAVAVRWLLD----A-G-ARDVVVLTRA---------------PRPVPA-PLDGLED-------RFVV 1304 Nocardia farcinica
Q5LV53   1169 GTYLITGGFGGIGLTLARHLMD----H-H-GANVILLGRDPlptdpaawlaghspADRTSR-RLRALAELEAlergEVMA 1241 Ruegeria pomeroyi
4J1Q_A    260 READVSDQHAVRHLLEEIKERYGTLNGIIHGAGSSKDRFIIHKTNEEFQEVLQPKVSGLLHVDECSKd--FPLDFFIFFS 337 
Q4KCD4   2806 RSLDVSDAAAVSQWIDGIYAEQGQLHGLIHSAGVIRDSLIMHKSASDFAQVLAAKVTGIENLDQAIGe--RPLDFMLCCS 2883 Pseudomonas prote...
Q4KCD8   4886 RAVDLASADQVEQLIAELVRDDRGLHGIIHCAGVTRDTLLAEKSIEDFAAVFAAKVDGVRHLDRYSAg--LALDFFVLYS 4963 Pseudomonas prote...
Q63LK8   1970 RVLDVADRDAVARMVEAIVGEFGALHGVVHCAGVLRDNYLLRKSADEFAQVLAPKVRGTVNLDFATRd-vRSLDFFVTFS 2048 Burkholderia pseu...
Q4KCD7   2909 QPLDLTDAQGLERLIAQICTAHGGLNGVLHGAGVNRDRLLAQKTPQDVVEVFAAKVLGTDLLDRACRr--LYLDFFVLFS 2986 Pseudomonas prote...
Q7N5R3   3606 LRADVADDAALTKALAQMRARFGAINGVIHSAGIEASGLLEHGTSQDWRHVMAAKVSGTQQLMTAISq--DPLDFVLLCS 3683 Photorhabdus laum...
Q5YVB9   1798 ERADVADRAAVAGIVARAHQPEHPLRGIFHAAGAVADNRIELMDLDQLTRVYRAKVHGARALHDAVEqagIEPDMIVLYS 1877 Nocardia farcinica
BAC69262 3489 ARADVADRAGLTAALAALRRDAGPVAGVVHAAGVLDDATVANLTDERVLRVLAPKVLGTTLLTELIPe----AGNLVLFA 3564 Streptomyces aver...
Q5YMZ6   1305 VRCDVADRAELAAALGDIREDGATIRGLVHAAEVFETAAFAEVTAGQLTRLFEPKVTAARHLLALTAh--DPTDFVLLFT 1382 Nocardia farcinica
Q5LV53   1242 IAADVANIDQMRRALTLAEDRFGALTGVIHAAGHIADGPALAKTEADLHRVLSPKMTGLRVLDELFPd--GVLELMVLCA 1319 Ruegeria pomeroyi
4J1Q_A    338 SVSGCLGNAGQADYAAANSFMDAFAEYRRSLAAskkrfgS------TISFNWPLW 386 
Q4KCD4   2884 SQAA-MGNLGQADYASANAWMDAYMHYRQNLAA------DgkrkgrSLSINWPLW 2931 Pseudomonas protegens Pf-5
Q4KCD8   4964 SIASVLGNPGQTDYAAANGYLDAFASLREQQVA------AgtrqgrSLAINWPLW 5012 Pseudomonas protegens Pf-5
Q63LK8   2049 SGAGVVGNPGQADYAVANAFMDAFAAHRASLGA------Arp--gvSVSIAWPIW 2095 Burkholderia pseudomallei
Q4KCD7   2987 SCSAVLGSVGQADYAAANAFIDQFAELRNLRVE------QglrfghTLSLNFPLW 3035 Pseudomonas protegens Pf-5
Q7N5R3   3684 SLASLVGGMGQADYAAANRYLDAVAHYWRQQAI------P------VTSVNWDTW 3726 Photorhabdus laumondii subsp. laumondii
Q5YVB9   1878 SGGSMFGIFGQYNYTAANLAVEALAEEWSRAGE------R------VLCVGWGHM 1920 Nocardia farcinica
BAC69262 3565 SAAGLLGSAGQSPYSAANAFLDAWAHHLSRTDR------R------ALSLDWGAW 3607 Streptomyces avermitilis MA-4680 = NBRC 14893
Q5YMZ6   1383 SAAGTLGAPGRAAYAAASAAADALAGGRRR----------------VLALGWEIR 1421 Nocardia farcinica
Q5LV53   1320 SSSTASRPAGQVDYVAANEYLNAFADSRQGGAT------R------VVAVNWGVW 1362 Ruegeria pomeroyi
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