5ULJ,5BTH,3FQD


Conserved Protein Domain Family
RAI1

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pfam08652: RAI1 
Click on image for an interactive view with Cn3D
RAI1 like PD-(D/E)XK nuclease
RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z and binds to a nuclear exoribonuclease. It is required for 5.8S rRNA processing. Profile-profile comparison tools demonstrate this to be a PD-(D/E)XK nuclease, with a full set of canonical active site signature motifs characteristic to the PD-(D/E)XK nuclease superfamily.
Statistics
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PSSM-Id: 400814
View PSSM: pfam08652
Aligned: 120 rows
Threshold Bit Score: 54.0466
Threshold Setting Gi: 307173137
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5ULJ_D              236 VDCVW-DYIPEDg---kDVLSHYMELKTTRIL-----ESNGQVV--NFE-KKLFKTWAQCFLMGIRKVVYGFRDDSFFLR 303 Scheffer...
EFN64237            209 iDGISsQQHITDtl--iGKTFEMIELKTLSIRqyneiGTEQHYKygTMRvNKVITWWSQNYLAGIERLICGLRNRNEEVR 286 Florida ...
WGS:AAPP:GF21826-PA 222 MDCIVsSQPVNFqdpnnLKHLEFVELKTGAYD-----MNRHQEQ--TFKlFKSANWWSQSFLVGIKTIYAGLRDTKGVVK 294 Drosophi...
Q9VXA8              223 lDCVDsKEPVDFkdcrvLDSLKFVELKTSVFN-----MNPHQIR--TFKsFKSANWWSQSFLVGITTLYVGLRDTKGMLQ 295 fruit fly
EDX18141            223 lDCVDsMEPVDFkdrkvLESLKFVELKTSALN-----MNKYQTR--SFNsFKSANWWSQSFLVDITTLYVGLRDTKGMMH 295 Drosophi...
XP_001991508        218 MDCIKsDVQMNLsdpkqLRAAEFIELKTTTNK-----MNGYCRS--LFNnYKSCNWWSQSFLVGIATIIAGKRDNKGLth 290 Drosophi...
XP_002011927        159 MDCIKsDVYVDLkdpeqLRLAEFVELKTAAYK-----MTQRQQQ--TFAnYKSLNWWSQSFLVGIDTIITGLRDDNGLVH 231 Drosophi...
WGS:AANI:GJ19359-PA 225 MDCIKsNVYIDLkdpaqLRLAEFVELKTTAHN-----MTKKQQR--SFDnYKSLNWWSQSFLVGIGTIIAGLRDNNGLVH 297 Drosophi...
WGS:AAQB:GK25715-PA 229 MDCIEtSQEVNLndakvLRSLKFVELKTSFQR-----MSPRQKS--NFElYKSSVWWSQSFLVGISTIYSGLRDQYGFVQ 301 Drosophi...
EDW32643            225 MDGIVsRNPVNFndpeaLKNLQFVEFKTGAFE-----AEARQQR--SFNfCKSRTWWGQSFLVGVKTIMVGLRDGDGICH 297 Drosophi...
5ULJ_D              304 D 304 Scheffersomyces stipitis CBS 6054
EFN64237            287 m 287 Florida carpenter ant
WGS:AAPP:GF21826-PA 295 E 295 Drosophila ananassae
Q9VXA8              296 R 296 fruit fly
EDX18141            296 K 296 Drosophila simulans
XP_001991508        291 v 291 Drosophila grimshawi
XP_002011927        232 D 232 Drosophila mojavensis
WGS:AANI:GJ19359-PA 298 E 298 Drosophila virilis
WGS:AAQB:GK25715-PA 302 D 302 Drosophila willistoni
EDW32643            298 d 298 Drosophila persimilis
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