Conserved Protein Domain Family
SLD3

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pfam08639: SLD3 
DNA replication regulator SLD3
The SLD3 DNA replication regulator is required for loading and maintenance of Cdc45 on chromatin during DNA replication.
Statistics
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PSSM-Id: 400803
View PSSM: pfam08639
Aligned: 46 rows
Threshold Bit Score: 182.608
Threshold Setting Gi: 294658215
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003348305  91 IFQNIRMQYFEALYHSKGSLAYFAKGPLSRARAAFHLDCDLNLEMNdLIDFLRSLVLTTALIDKKY--RETLPEVIGK-- 166  Sordaria macro...
EMF17974     230 TLQELARQYLDALYLSRTPLAYFVKGPLARTRAAFS------SHPAdLISFLRGTVLTSATMDKKF--RDVLLELVKD-- 299  Sphaerulina mu...
EME49439     242 PLEDLTKQYLEALYISRLPLAFFVKGPLARARAALT------SQPAeLVNFLRGTILPAAVMDKKF--RERIVELVKE-- 311  Dothistroma se...
XP_007782792 233 LFENFISQYLEALYLSKASLAYFAKGPISRVRASFAGSQDGSFQLSeLAIFYRSILHSTTSIDKKY--KEKLPELIKG-- 308  Coniosporium a...
CBX92696     304 QLESLVQQYLDAVYLSKTSLAYFAKGPMTRLRNTFTAPVEGAPATHeLVSFLRAMILSPKSSEKKY--YEKLPAVIKA-- 379  Leptosphaeria ...
EMD91743     259 QLDLLVQQYLDAVYMSKTSLAYFTKGPLTRIRNAFTLAEEGAPPTHdLVTSLRAMLLSPKASEKKY--YEKLPSFIKA-- 334  Bipolaris mayd...
EFQ93293      53 qLALLVHQYLDAVYMSKTSLAYFAKGPVTRIRNAFTSTEEGAPATHeLVAFLRTMLLSPKASEKKY--HDKLPLLIKA-- 128  Pyrenophora te...
EGX53339     247 glaRLRQQYYSLLYTSKSSLQYFPKTSLSRARVLFPTNGESPVSRLdLLLCLENMVMSVEECDDKY--RAGIRDVSNA-- 322  Arthrobotrys o...
EDK44813     233 PETYIQTKYYSSLYALTEPLNYFPKTALTRYRNMCT-------SQEeVSSILRSIILSIDEFDRRY--ARGVKLFLSEac 303  Lodderomyces e...
XP_002770737 185 PVKFLYSRYYSILYSLNTPLSYFPKTTISRFKNLCG------NDNSaVKEHLSSLHLSVKELDDRHggKYGILKTLDV-- 256  Debaryomyces h...
XP_003348305 167 ---------------------MKTVVEDsDQGr-aQPKPR-KKRAKKPKLGKN-----GLYPSEEEHIERWWVTHkpsti 218  Sordaria macro...
EMF17974     300 ---------------------FAILDTP-------GTKPK-RKRKWKPKRDKQ-----GLFVGERDHIEQWWQKM----- 340  Sphaerulina mu...
EME49439     312 ---------------------YSVLEPHdPKP------QQrKKRKWKAKRDKT-----GLFIDEKDYVEQWWRRE----- 354  Dothistroma se...
XP_007782792 309 ---------------------MPMAFCSdEEPmtsATVRRkKTTTRKLKPSKD-----GMYSDETEYVRKWWLS------ 356  Coniosporium a...
CBX92696     380 ---------------------LPPGTLSeDEHm--HGANKvKKSKKKIKLSRN-----GVYPNEDLMIRKWWLS------ 425  Leptosphaeria ...
EMD91743     335 ---------------------MAPGSYSdDETm--AGASKaKKSKKKAKLGRD-----GVYAQEEILVKRWWQS------ 380  Bipolaris mayd...
EFQ93293     129 ---------------------IPPGSYSdDEVa--TGAGKaNKSKKKMKLSRD-----GVYPREETFIKKWWQS------ 174  Pyrenophora te...
EGX53339     323 ---------------------RRAQSGMaDQMt--------NDQLESAIVPPN-----CLRDNEIKYVLKWLKSL----- 363  Arthrobotrys o...
EDK44813     304 nyfeldsmeklkaklnilvfmAQENEGDnEEG------KNgQEEQEKQKLKIT-----GITPDQ---------------- 356  Lodderomyces e...
XP_002770737 257 ---------------------SKIGTGDfDMK------TKyENQNQKEFLNKNhdlfvKLTATEKN-------------- 295  Debaryomyces h...
XP_003348305 219 qDDEKMA------TAPEAKHH-------ISVLRRRETQLQMIIILEIL-------------ALEplnrpvEATEdsqlpg 272  Sordaria macro...
EMF17974     341 -EGTGKDsgshepFEAVLRRR-------GQAIRIRETSLQIIIIMEVL-------------ALE--------AStpllpa 391  Sphaerulina mu...
EME49439     355 -DDGERIsgpnetFDMAVKRR-------SQRLRNRETFLQVILIHEIT-------------ALE---------Aspphdp 404  Dothistroma se...
XP_007782792 357 -DWAITSqrdfgsADDVARKR-------TANLKVRETLAQLIVAMEVM-------------ALEslpa------------ 403  Coniosporium a...
CBX92696     426 -ELPSSDsmgaetIDQRIKRR-------VGDLRVRETLAQLIIMLEII-------------ALEslh------------- 471  Leptosphaeria ...
EMD91743     381 -ELPTGDamatetMDQRIKRR-------IGDLRVRETLAQLILMLEII-------------ALEams------------- 426  Bipolaris mayd...
EFQ93293     175 -ELPNGDsmatetMEQRIKRR-------IGDLRVRETLAQLILMLEVV-------------ALEals------------- 220  Pyrenophora te...
EGX53339     364 -SDDDGPirslgqEEIHLQKC-------TTELRSRETELQVIVILEIL-------------AIK------EGLSdektke 416  Arthrobotrys o...
EDK44813     357 -----------------MQKV-------LLQLKIREAQLQIVILLEYFwsieidevklvenHLEkvtkelQKSHskqnvs 412  Lodderomyces e...
XP_002770737 296 -QNDINDtntnanQEKQVHSSddnnlsfALDLKVREAQLQILILLELLdcwqvvesdflatNLK---------------- 358  Debaryomyces h...
XP_003348305 273 letqGTLGG--AKPEANk-------------KKSRTTN------------------------------------LPLLLD 301  Sordaria macro...
EMF17974     392 vpalDGVQD--VGSQTQenrpad---ldkkqRKKKDSN------------------------------------MTAILE 430  Sphaerulina mu...
EME49439     405 latrMDAGE--SQDVTLrdqeaqlnakeknpRKNKEID------------------------------------VAVALA 446  Dothistroma se...
XP_007782792 404 cqlpQMVDD--PGGVESqtprttdavsqkkrKSRKQQD------------------------------------MSSIMD 445  Coniosporium a...
CBX92696     472 --tyRPPLDdnEADADIaklqetqtnkkpkkRTKKVDD------------------------------------INLQLD 513  Leptosphaeria ...
EMD91743     427 --tsKAGGQ----QLTKeetqdqseqsaprkRKKKLDD------------------------------------INVQLD 464  Bipolaris mayd...
EFQ93293     221 --tyKPPSDdtqnqge---------qnmtkkRKKKLDD------------------------------------ISLQLD 253  Pyrenophora te...
EGX53339     417 yeklKKAAD--RRRRRRekagqg--ddgekkKRKKKMD------------------------------------LLVLLD 456  Arthrobotrys o...
EDK44813     413 lvrkKKKKSkgKSKEKKekkvkrsdeekgnnSKKNDSNedenvdtkelkritpklltnigeetksendywaaleLFSYLN 492  Lodderomyces e...
XP_002770737 359 -------------RQEKeekqmtkqkkkslvRKKSITSkkivptflgmgvdiqd----khivsqpasteinefiVYETLN 421  Debaryomyces h...
XP_003348305 302 MHADRLCIWQSTTLDEvKALTDSQPsaddqES-------PAENSNSDPLRDFCVDIIVPFFSARLPELCDSINRKLGGPV 374  Sordaria macro...
EMF17974     431 TLIERLNIFYTLESSPvKTMEDENg--------------SIKPDTKDELRTFATEVIIPFFASRIYEIANSTSKKLGGPS 496  Sphaerulina mu...
EME49439     447 TLLDRLCIWYSIENSSpIKNGTAAEd-------------DGTRETNDDLKSFARDVIVPFFHSRIPELANATSGKLGGPQ 513  Dothistroma se...
XP_007782792 446 VLVERLCIWQSVEQEE-----SSAKlpsrnQAsenthitAGGASNSDILKDFCLEVIIPFYMNRIPDKAASINRKLGGPG 520  Coniosporium a...
CBX92696     514 LLLDKLCIWHAT--EElGILDFDSKpttqhEGld----gANKLGANDRLHSFCVEVIVPFYMNRLPEQALTANKKLGGPV 587  Leptosphaeria ...
EMD91743     465 LALDKLCIWHAT--EElGILDFDAKpsqqnEDvd----gTGRNGSSDRLHSFCVEVIIPFYINRLPEQALMVNRKLGGPA 538  Bipolaris mayd...
EFQ93293     254 LLLDKLCIWHAT--EEmGILDFDSRq---nDGpd----tNGRGDSNDRLHSFCVEVIIPFYINRLPEQALMVNKKLGGPT 324  Pyrenophora te...
EGX53339     457 LLVDRLCIWHSIGTGEePKSSQPKP-----------------KDAKDRLRHFCIEIVIAYYSSRLPNICEDIRCKCTGKI 519  Arthrobotrys o...
EDK44813     493 ALVDRLNLWEVLLSSK----------------------------DINNLRGFMAYVLIPYYHKRLPHLMKHIVQNMKLTN 544  Lodderomyces e...
XP_002770737 422 TLLDRMGLWDTLLDKS-------------------------TGDQDESSFGFLAYVLIPYFRQRLPLTIKYIIERVKGLS 476  Debaryomyces h...
XP_003348305 375 IQAPkEKAkTVV-----ASKpKPGaPAKRVTAt----KKENERTLQRV-----------LSNErm-------krSVSRG- 426  Sordaria macro...
EMF17974     497 APRPiDKNsTAV-----PTCrKPGePTTRQPP-----EKKARKPLGRT-----------STDTl---------nKVGKN- 545  Sphaerulina mu...
EME49439     514 APTPkRRTaS--------KSrRPGePAVRQAP-----EKKPRRPLARV-----------STDTt---------eYSSKR- 559  Dothistroma se...
XP_007782792 521 APSP-AKPtAIQststtATLrKPGePEVRQPP-----PKKIRRPLQKV-----------SSEVn---------------- 567  Coniosporium a...
CBX92696     588 HTAPsKRK-----------AmKAPiTSRTLETlnepdVKKSRRSLARV-----------ATDNt---------------- 629  Leptosphaeria ...
EMD91743     539 HSLPaKRK-----------AnKPPlSSRRSRDpkepdAKKSRRSLARV-----------ATDNt---------------- 580  Bipolaris mayd...
EFQ93293     325 HSQSsKRK-----------AmKPPvTSRNSGDskepeIKKPRRSLARV-----------ATDNt---------------- 366  Pyrenophora te...
EGX53339     520 K-------------------------QTRKDHdlvieGEETQLDISQIgsqd---ampdTTEDslf-------------- 557  Arthrobotrys o...
EDK44813     545 MKFTsLKKkKTAeggddDRDeKTGkE-----------DKEDQYDLERIdenyvkdddldQVDQadqadqadqvdQADQAd 613  Lodderomyces e...
XP_002770737 477 LKL----------------NsKPNrQ-----------NMPKQLNLNETn---------eITNEvtnerdstantQASRTs 520  Debaryomyces h...
XP_003348305 427 -------PGGt---IALLRSASA------TAIP---GLKREGS--------EP-LLGMI---PkgE-------------- 461  Sordaria macro...
EMF17974     546 -------P------PVLQTSVTD------LDALa-tLIKRENS--------ETpSLSLQnieAtkRisrkr-----ttal 592  Sphaerulina mu...
EME49439     560 -------P------PALHRAATD------SDALv-sTFKREMS--------ETpSLHSIpvvKkgKphpqtmqpkrvsll 611  Dothistroma se...
XP_007782792 568 -------PTSrr-pPSLARSATD------SGIVp--GLKREGS--------EIpLLAIPrqeSqiRrggs--------la 615  Coniosporium a...
CBX92696     630 ------gRTIervtPALNRSTTD------TALLn--NIKREGS--------EVpLSAIPfqrSpsKsarq-------sms 680  Leptosphaeria ...
EMD91743     581 ------gKIAerttPSLGRSATD------SVLIe--GVKREAS--------ETpLSAIPfrrSpsKgarq-------sms 631  Bipolaris mayd...
EFQ93293     367 ------gRTIerttPSLNRSATD------SALPe--RVKREGS--------EAsLSSIPfrrSpsKsnrq-------sms 417  Pyrenophora te...
EGX53339     558 ------lkSAygsrPTLSRSLTA------PAGRh--QLERAESsfsaslhgETqDLTFDfaaQvsQdkeamktsfrggit 623  Arthrobotrys o...
EDK44813     614 qvdkvgvQHQlvgrPKLADGSANesiikdISIS---TLRRSKS--------Nlg-------------------------- 656  Lodderomyces e...
XP_002770737 521 kfakvhiDPRr--vPFLKKSSSTia--skYDLLpafSLKRSKStl----------------------------------- 561  Debaryomyces h...
XP_003348305 462 -AVAVKEKNVSiFSRSAGslgnNEDAKAKKKARL---EAE-LKEAISALKKPNRALAGKEIVEEAE-RRTAQPK---SKL 532  Sordaria macro...
EMF17974     593 dQYAARHKQID-LSAMTQ----NLQQKAAKNKSV---EDKiLRDALNGIRKPNRALATEETARNAD-ESFARALargKPS 663  Sphaerulina mu...
EME49439     612 eQASFGRREVD-LSAMSQ----ANDTKMRKKADV---EAK-LRDAITTLKKPNRERAVEEIAKNAD-QSFAKAIa-kGRN 680  Dothistroma se...
XP_007782792 616 dIKRFRQREID-LTAMTA----ANEAKQRKKAAV---ENE-LKTAISALKKPNRGLAVKELVDSADqRRQQSG------- 679  Coniosporium a...
CBX92696     681 qIRHLQGRQID-FNRPSA----AAEAKMKHKQRV---EED-LQEAILALKRPNRGLAAGSYVADKE-QRGLGLAn-kSRK 749  Leptosphaeria ...
EMD91743     632 qIRHLQGRQID-LAEPSA----AASAKMKQKQRV---EED-LQEAILALKRPNRGLAAGGYIAEKE-QRGVGQAs-kSRK 700  Bipolaris mayd...
EFQ93293     418 qIRHLQGRQID-LAQPSA----AASAKIKQRQRV---EED-LQEAILGLKKPNRGLAAGGYAADNE-QRGLGLAn-kSRK 486  Pyrenophora te...
EGX53339     624 nTKKTAERRV---VDMAP--------RTKRRKTEcgdESQ-LKDAIKNIAKPNRLAVAEEMVSASA-QRMKIT----GRK 686  Arthrobotrys o...
EDK44813     657 qTKDLDKRQVN-LDLKPSq------------------KQE---SRIGGNSDPNSSLI----FTKAK-RSKSIPQissTMI 709  Lodderomyces e...
XP_002770737 562 sSKNLQKRQVD------------------------------MSSNLKSFSESNRDNI----------EKSSTLSrslSEK 601  Debaryomyces h...
XP_003348305 533 NKKQPRAA---------------G--------VQ-----IKATP-ANNRFKDVFT------------------------- 558  Sordaria macro...
EMF17974     664 KSRTQRNA---------------AggsreaktITatprhIKATP-APRR------------------------------- 696  Sphaerulina mu...
EME49439     681 QAQAQRKA---------------Gaekg-lpvVSaspgrIKATPaPKRR------------------------------- 713  Dothistroma se...
XP_007782792 680 --------------------------------VQ-----VTATPkRASKTKNITQsk----------------------p 700  Coniosporium a...
CBX92696     750 QANPVRKIik---------------------dVQ-----VTATPrVGRRTKNMVEqtptqpqpqlqphphnpfvrnstdg 803  Leptosphaeria ...
EMD91743     701 PTVTVRKTik---------------------dVQ-----VTATPrVSRRTKNMVEqtpvqqhyd-------pfvrspgee 747  Bipolaris mayd...
EFQ93293     487 PTTTVRKTik---------------------dVQ-----VSATPrAGRRTKDIVEqtpsrhqhn-------pfirlpage 533  Pyrenophora te...
EGX53339     687 PKKTIRIPvat-------------------ntVQ-----VAATPrKNNR----TLk------------------------ 714  Arthrobotrys o...
EDK44813     710 TNTPVKKK---------------Qlqt--msfSQ-----VEATPaSKTN------------------------------- 736  Lodderomyces e...
XP_002770737 602 SDSGSRRQiifgnakklksqpdiIlnnpqtafSQ-----VEATPaKRKP------------------------------- 645  Debaryomyces h...
XP_003348305 559 KESQPlHLDHLFEEDGAAiPSSASVV---PASTLPRKFTNVFatsTSPntgqggnpssqtgdearqipphkqvqetplrk 635  Sordaria macro...
EMF17974     697 ------RAANPDHSLGELgSGSTAVV---PSTATRLPAe------PHVvpgstfti------------------------ 737  Sphaerulina mu...
EME49439     714 ---------DERFAMNSRgSADTSFV---PSSCTRLMAR------PGDapsaip-------------------------- 749  Dothistroma se...
XP_007782792 701 AL----RSPPPNTADGPApRSSGACI---PSSTVRPAASFLFpgtERRes------------------------------ 743  Coniosporium a...
CBX92696     804 AP-----------------PLSDFCI---PSSATHQPHSMMPatgHRSasg----------------------------- 834  Leptosphaeria ...
EMD91743     748 AP-----------------HSSGFCV---PSSGVRPRPGMVAardQGHata----------------------------- 778  Bipolaris mayd...
EFQ93293     534 AP-----------------GSSDLCI---PSSTVRPPAFMVPatgHRRpta----------------------------- 564  Pyrenophora te...
EGX53339     715 LLERKpDVPTAIAEEEDHiPPSSQIV---PQSSIKDSRKNERd------------------------------------- 754  Arthrobotrys o...
EDK44813     737 --------ANASGFTEIFsPAKDESIfssPVENFKKPSKVKQpnlLTQrlheaaav------------------------ 784  Lodderomyces e...
XP_002770737 646 ---EAvTAGISSEITTPThPNRYQKI------------------------------------------------------ 668  Debaryomyces h...
XP_003348305 636 ksvpqislpqideeveeatpvppskNVDVHVQATPVR 672  Sordaria macrospora k-hell
EMF17974     738 ------------------pptghrhRQQKNVLETPSR 756  Sphaerulina musiva SO2202
EME49439     750 --------------------qtghrSRHSNVEETPSR 766  Dothistroma septosporum NZE10
XP_007782792 744 -----------------------rtGLHTTVAETPSR 757  Coniosporium apollinis CBS 100218
CBX92696     835 ----------------------rrgLAHSSIAETPSk 849  Leptosphaeria maculans JN3
EMD91743     779 -----------------------psLGQSSIAETPSK 792  Bipolaris maydis C5
EFQ93293     565 -----------------------rdVAQSTIAETPSK 578  Pyrenophora teres f. teres 0-1
EGX53339     755 -----------------------------EVQATPSK 762  Arthrobotrys oligospora ATCC 24927
EDK44813     785 ------------------avstvstSNQVDVEATPKK 803  Lodderomyces elongisporus NRRL YB-4239
XP_002770737 669 -----------------------------SIAKTPVd 676  Debaryomyces hansenii CBS767
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