Conserved Protein Domain Family
Pet127

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pfam08634: Pet127 
Mitochondrial protein Pet127
Pet127 has been implicated in mitochondrial RNA stability and/or processing and is localized to the mitochondrial membrane. The Pet127 family is part of the PD-(D/E)XK nuclease superfamily including a full set of active site residues.
Statistics
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PSSM-Id: 400799
View PSSM: pfam08634
Aligned: 93 rows
Threshold Bit Score: 284.382
Threshold Setting Gi: 74855172
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q75A95        150 FVPPSRDLRLLERAKEGQARYVSSTSAMSGVLSHLHYLLSNFRPLNGRHLSATL-LR---KDAQVTKCCKMTSSMLLQRr 225  Eremothecium ...
ESK94953      190 FVKSSSDEDLWSLARKEGRRFGGSTSSLSGMLSQIYFLISENKEVDTSTLSAGF-RR---QPSNFTPGQRMAASVVFNY- 264  Moniliophthor...
EFI99544       79 FVKSSRDEDLRTLAVREGKSFAGSTSSLTGMLSHIYFLISGDRNVDISPLSRAF-ED---KPVDFTPGQRSPASTVFNY- 153  Schizophyllum...
XP_004361794  376 YMIPSQDPELLTKTSDFKCKFLSSTSSITSVLAAMYLSVFKKYTVNQFGLNSQLq-----SMSKFTPQVLKPTAITLTAv 450  Cavenderia fa...
Q54T03        594 YMRPSEDKRLLDITKEHKAKYLSSTSSITSILTHLYLSLVKGKAPSSSPFSPPIlTRllpLKMGFIPSIVKPTSIHLTPl 673  Dictyostelium...
XP_003292100  409 YMIPSEDQKLIEITEENKCTYFSSTSSITAFLTHLYLAVSKSKAPPSSMYSSSL-TD---LSGSFIPSVLKPSSIHLIPv 484  Dictyostelium...
Q24CB9        192 YIPPSNDKLLLDFAKQSNIRYVMSTSTISNVLSQIYFLFSSFRNPNFDNISSAY-DQ---EPKKYMISQRKPTSNMLRkl 267  Tetrahymena t...
A0CMI4        139 YVPPSKDITLQQFAKALNLRYCVSTSTFSNVLSQIFYLLSGFHGPDFSSIFEQF-PD---EPRKFMISQRKPTSALLHKv 214  Paramecium te...
EGR34709      157 YIPPSNDQLLLDFAKKSNIKYVVSTSTISSALTQIYYMFSGFRNPLYDNISSNY-EN---EPKKYMISQRKPTTNYLRrl 232  Ichthyophthir...
EFC48349      476 FIPPSQDTTLHKLMDQNPCRYQSSTSSITSPLVSLYLALSNYKPTRARNLENFKy-----LTSSFTPAVRKPVVFILRPk 550  Naegleria gru...
Q75A95        226 sQa--PPIFSLSSDS-----SADR-EIILSQLGHALEALLTTDQADFA-RIYDKGk------RAQPgsqplgkghaTSAF 290  Eremothecium ...
ESK94953      265 -N---DGVYAIDSDPsk-seEAEK--NILTWMGTLLEKYLTMSTEEFL-AYMRTHpqpviedEKVSdg------ptREAY 330  Moniliophthor...
EFI99544      154 -K---DGVHMIDSDEdkpgvKSDQ--NILTWMGTLLEKYFTMEPEEFA-RYLRAHd------HPQTesd-----nmREAY 215  Schizophyllum...
XP_004361794  451 kDd----IWAIDINNg----NIPKkNEVLMELGHSMEKMLTLEEEEFLaKLLKTNnsvpv--------------efddSY 508  Cavenderia fa...
Q54T03        674 dGg----IWAIDTNSg----NITQdNTILMNLGHSMEKMLTLDEEEFNqKLLKSNvgdkp-------------vefpdSY 732  Dictyostelium...
XP_003292100  485 kDn----IWSIDNNSg----NAEKsNVILMNLGHSMEKMLTLPEDEFNsKILKSNnpgdp-------------vefpdSY 543  Dictyostelium...
Q24CB9        268 d--pknGIYALDSDSgl-feTPNQ---ILMDLGKVMERQLTLDPETFRnGLLKNSpvkeq-------------lidddHH 328  Tetrahymena t...
A0CMI4        215 dEn----MYALDGDPgi-feEELI--ELLMS-GKIVERQLTQDQEEFEnRYIKLDpsmp---------------lvedFH 271  Paramecium te...
EGR34709      233 d--kekGIYAFDSDSgi-feAPNK---ILMDLGKILEKQLTLDEQTFKdALLKTStknil--------------ieddHH 292  Ichthyophthir...
EFC48349      551 lSklghTFYSIDSYKfl-fePRSN--QILMDLGKVMEKLFVMEPEDFEkRFVKQYcgeeqt------------vedeeVY 615  Naegleria gru...
Q75A95        291 RFNK-HGRFLLRSQLDAH--DPKL--P-GTGVFDLKTRAVAAVRHDLDYVSQNgntTGYQLMRRSGQFESYEREISELVR 364  Eremothecium ...
ESK94953      331 RYSK-SEKFVMRSQLDCH--DNRL--P-GTGVFDIKTRACMPIRMDILNFKES---SGYLITKQHGLTESFEREYYDLVR 401  Moniliophthor...
EFI99544      216 RYSK-SQSFIMRSQLDCV--DPRL--P-GTGVFDMKTRACMAIRMDLLNFEES---SGYLIRQQHGLLESFEREYYDLIR 286  Schizophyllum...
XP_004361794  509 VFTK-FDNLMYRSQIDCY--SDKIkgKgERMTFDLKTRATRQIRYHVWEHDVH---LDYHLKNVVGLNESYERELSDMTR 582  Cavenderia fa...
Q54T03        733 IFSK-FGSLIYRSQLDCK--SDHL--PeGRNTFDLKTRSTSSIRNNASTSFNY---VSQRISRLSSDKDSFESEYFDLTK 804  Dictyostelium...
XP_003292100  544 IYSK-FDKIIYRSQIDCI--SDNL--PeDRNTFDLKTRATNAIRMNVSETNNF---ISHHINRLFNCNNSFEREYLDLSR 615  Dictyostelium...
Q24CB9        329 RFMKlNKNICLRSQIDCQaiDPKTgqP---FVFEIKTRAVCPIRYDLNNYLDH---IDYRINTKFGLHSSFEREYYDLIR 402  Tetrahymena t...
A0CMI4        272 RFMElNNEMCLRSQIDCR---NRSenP---IVFEIKARGACPIRYDYPNYRDY---LDYEINQYKGLFQSFEREYYDLIR 342  Paramecium te...
EGR34709      293 RFMKlNGDICLRSQIDCTaiSKETnqP---IVFEIKTRASCPIRYDLENYKDY---LDYRIVQKYGIHSSFEREYYDLIR 366  Ichthyophthir...
EFC48349      616 RYLR-HGSFLLRSQLDCY--HPQY------GVFDIKTRATNPIRINMEKYQKF---TNIKLKMIKGNYNSYEREFYDMVR 683  Naegleria gru...
Q75A95        365 NAMLKYSFQARIGAMDGIFVAYHNISRIFGFQYIPLEEMDYIIHSsadraaamsltrresalqelfnpveyvtryrfent 444  Eremothecium ...
ESK94953      402 SAFLKYSFQARIGNMDGVFVAYHNTARMFGFQYVSLDEMDQRLFS----------------------------------- 446  Moniliophthor...
EFI99544      287 SAFLKYSFQARIGNMDGIFCAYHNVARVFGFQYFGLEEIDARLFG----------------------------------- 331  Schizophyllum...
XP_004361794  583 SSGIKYAFQAKIGNMDGLYIAYHNTKKIFGTEYLPLEKLERIVFW----------------------------------- 627  Cavenderia fa...
Q54T03        805 SGAIKYALQAKIGHMAGIFICYHNTKRIFGSEYLDLEELEKSVFW----------------------------------- 849  Dictyostelium...
XP_003292100  616 SGGIKYALQAKLGHMAGIFICYHNTRKIFGSEYIDLKELEKSIFW----------------------------------- 660  Dictyostelium...
Q24CB9        403 GAMLKYAFQLKIGRMDGAFIAYHNTKEIFGFEYVKTKEIETRCFG----------------------------------- 447  Tetrahymena t...
A0CMI4        343 GAFLKWAIQLKIGRMDGAFVAYHNLLEIQGFEYIKSSEIYKRVFG----------------------------------- 387  Paramecium te...
EGR34709      367 GGFLKYCFQLKIGRMDGAFIAYHNTLEMFGFEYVKTTEIENRIFG----------------------------------- 411  Ichthyophthir...
EFC48349      684 SVFIKYSMQGRIGGMDGMFLAYHNTVELFGFEYIKLGEIDKHVFG----------------------------------- 728  Naegleria gru...
Q75A95        445 arEtAstLAQAEFNYSMRILEHLFD 469  Eremothecium gossypii
ESK94953      447 --Q-HkgAGDRVFQKCVELMEVvad 468  Moniliophthora roreri MCA 2997
EFI99544      332 --M-EpgAGDRVFRKCVAMLETVae 353  Schizophyllum commune H4-8
XP_004361794  628 ----GnhIADDVFRITSTLLDKILt 648  Cavenderia fasciculata
Q54T03        850 ----StdMANRSFLMTNSILEDLLN 870  Dictyostelium discoideum AX4
XP_003292100  661 ----TnhMADVNFNLTNQLLQNVLD 681  Dictyostelium purpureum
Q24CB9        448 ----NqfFADASFVVCSKILTNLLD 468  Tetrahymena thermophila SB210
A0CMI4        388 ----TeeFSDLSLLVGSRIATKLFd 408  Paramecium tetraurelia
EGR34709      412 ----NtlFADASFVICSKILTNLLN 432  Ichthyophthirius multifiliis
EFC48349      729 ----SphMAERFFSLLLDLLGEVLD 749  Naegleria gruberi
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