4WW9


Conserved Protein Domain Family
CGI-121

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pfam08617: CGI-121 
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Kinase binding protein CGI-121
CGI-121 has been shown to bind to the p53-related protein kinase (PRPK). PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumor suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation. Interestingly this family also include archaeal homologs, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.
Statistics
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PSSM-Id: 400784
View PSSM: pfam08617
Aligned: 154 rows
Threshold Bit Score: 58.6974
Threshold Setting Gi: 503664067
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4WW9_B        19 FEQV---KNA--KEI-------RSKM--S--ELSTs----fAFIDPRLVCSGEQMYSAIYKTLiev------kyN---KM 69  Saccharomyces c...
WP_013179548  19 ilgI---KNAvvNNE-------IFQL-----NKKFe----fQMINADYIATIEHIKHAILQAM----------------- 62  Methanococcus v...
Q18DI5        16 FVSI---VDKieKGT-------GATI---------------QAFDARYIVNQKHIKRAIECADra-------------rr 57  Haloquadratum w...
WP_013898143  22 LNQIascNNVlvQAM-----------------------------NADKIAGQEHIMFAIEKALss-------------ie 59  Methanosalsum z...
Q4UGL2        65 FNSI---KTP--KSI-------------------LdfnvlfLVLRPSLILSVDHLLHSVARALtn-------------vl 107 Theileria annulata
Q4DY70        12 YHDV---RDA--ASL-------HEQFkkRsi--------saAVIDSAYIMSRLHLVVALHRISsapliighddcQpkmTR 71  Trypanosoma cruzi
XP_002259700  19 FKNV---TNA--KELlrvynekTQAV-------DPdmrrffLLLDGQLIFSDNHILHSLYRAYhn--------------a 72  Plasmodium know...
Q8I3Y9        20 FKNV---VNS--KDLlesytksMN-------DNICyindffLLLDSNLVYNENHILHSIYRAHhn--------------f 73  Plasmodium falc...
XP_001329122  16 FENI---GDP--QTI-------NDYI-----KANQpp---vALIDARTIISLAHVQVAILNMRti-------------qe 62  Trichomonas vag...
XP_004084365  20 FKDV---NNA--AEL-------RQDA--VegNIHA------ALINPTMLLSPFQALLAANKAIhsq------siG---KM 70  Japanese medaka
4WW9_B        70 RTRN-LNS----ECVLCLSPTSNISDAFLKFGIK--DD-SSQLICLKFHTNtdd---vdkEQLRTIMTSIVK-G-QEI-E 135 Saccharomyces c...
WP_013179548  63 TKKN-ISNnfwvEILVRASATRQIATAIKLLGAK-----SGDVCLICNDEEt-------aNIIIDKIGGIVQ-K-NSVeF 127 Methanococcus v...
Q18DI5        58 RNNN-IARdrsiEMLLYAAGRRQITEALE-IGVS--SGlNRIVVAIDGGNE-------------IEAAKSIEsN-----T 115 Haloquadratum w...
WP_013898143  60 KGSN-LANdpgiEIMRYASGKRQIDEAFS-MGVR--KG-ENMLALVVMGDE---------NDVRESVTELKE-------I 118 Methanosalsum z...
Q4UGL2       108 SSKP-VSSnfttEVAFMLSGSSSVGKSLERVLLSknDK-SSPALILTLSQN----------KSRDSILDIINgVqDDIsN 175 Theileria annulata
Q4DY70        72 KSTArTAR----DVFAALSHTRNLYRVLEHLTCS--ET-TRAVVIVLSAPT---------EEDVAAVLDIVQgVrHGLlS 135 Trypanosoma cruzi
XP_002259700  73 LTKKrVTRnivlEVFFFLSAHENINECLKQYQIR--DS-SSSVIYVGVNIP---------RDEVHSFTNLIC-G-QST-S 137 Plasmodium know...
Q8I3Y9        74 QSKKrITKniflEILFLLSPHENINECVKQYQIK--ND-SSSVIYVGINIS---------KDQVDMFIKSVQ-G-DQA-D 138 Plasmodium falc...
XP_001329122  63 RDQT-QSKsiylEILRCLSPDGRLNGALKFCAIQ--KD-TTAVIAITFEDEfpsipglsdPKTFDQFLANPK-------- 130 Trichomonas vag...
XP_004084365  71 KTRS-LNS----EIIFNLSPTNNISEAFKRFGIS--HQdRS-LLVVVVHSRd-------dSEVLSHIAIRVD-G-QEV-P 132 Japanese medaka
4WW9_B       136 FND---DNLSRFYDEALIRKIYKLSDDFKPQDVNG-LSRALVDAIQLR 179 Saccharomyces cerevisiae S288C
WP_013179548 128 LDVpndVNNEK---FKKIVELYGLK----NVNSSKeLVKRVLEEIAIi 168 Methanococcus voltae
Q18DI5       116 LDTpadEVLGS-YDPDLVQPYFDIT-ANEIDVVNGdTESLVLERVALl 161 Haloquadratum walsbyi DSM 16790
WP_013898143 119 ITEkplLKCSS-SKINILMAQFNITEEEIDAVGKEkIPDLVIERVALv 165 Methanosalsum zhilinae
Q4UGL2       176 LDKy--TK------VDDLTKEFKIT--QEELKLPGgLEASILCRIGVK 213 Theileria annulata
Q4DY70       136 LET----Y----RDEAAVREFYGVG-----ESEAAaLEVTIVNRLAts 170 Trypanosoma cruzi
XP_002259700 138 VDD-----IRFLHDEKQIMQNFKCT------GEVAnLERFIYHTIASK 174 Plasmodium knowlesi strain H
Q8I3Y9       139 FNE-----LSFLHDKKKILENFKCD-------NMDnLERFIYHNIASK 174 Plasmodium falciparum 3D7
XP_001329122 131 ------------TDFDKIKKAFKLS---DAMLATYsHEQLVITTLSVL 163 Trichomonas vaginalis G3
XP_004084365 133 VEE-----FSSFSDPAKIRKLYKVSPQE--ES-GG-LLDAVVCRMATK 171 Japanese medaka
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