Conserved Protein Domain Family
Rad9_Rad53_bind

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pfam08605: Rad9_Rad53_bind 
Fungal Rad9-like Rad53-binding
In Saccharomyces cerevisiae the Rad9 a key adaptor protein in DNA damage checkpoint pathways. DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with this region of Rad9, when phosphorylated, via Rad53 pfam00498 domains. This region is structurally composed of a pair of TUDOR domains.
Statistics
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PSSM-Id: 369994
View PSSM: pfam08605
Aligned: 7 rows
Threshold Bit Score: 153.716
Threshold Setting Gi: 74668032
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4WES3  844 DSSPIALNQVI---APWSGQ--KRAYYPATCVGKppGISQTR-VLVKFEDSApLEVPMGAVKRLELKIGDAVKVDMphvP 917  Aspergillus fumigatus
Q74ZM5  330 DKSLLNKYDIIddsAVWCYSs-NLTYYPAKLLVS--HTNTAT-SVVLFKEGE-YEVSSEDLHYLDLRVGEQVICNH---K 401  Eremothecium gossypii
Q5ATX5 1376 DNSILVPNQVL---APWRGQ--KRAYYPAVCLGTpfGTSQDQ-YMVKFEDSApVEVPKGAVKRLELRIGDAVKVDMphiP 1449 Aspergillus nidulans
Q6BNY6  574 ALNVLTQTDIHymeSVWVSF--KFNMYTGKATKV--GHDN---LIVEFEEGS-YSIKNSDLYLLDIRIGDKLRTRS---S 642  Debaryomyces hansenii
P14737  772 DNSFLSKDDIIfgnAVWCQYtwNYKFYPGILLEV--DTNQDG-CWIYFETGR-SLTKDEDIYYLDIRIGDAVTFDG---N 844  Saccharomyces cerev...
Q6FV45  536 NLGTLEPKDIIfedAVWYQYdaNLKFYPGRIESI--DYIRNK-AQIRHKTGT-VEVNIGDVYYLNLLIGDHVDCGG---Y 608  [Candida] glabrata
Q6CK71  495 DEMQLTKKDVLfnnAVWYYFn-DCNFYPGKILSE--QRTKPGyCSVLFEKRQ-NDVRVEDIYYLDIRCGDKVHWKM---N 567  Kluyveromyces lactis
Q4WES3  918 kvTHIIRGFEDKisaEDLTkaasdgvlpITDVYGYTTLILgpKQRKSlpsGGLTGPDNLIKvPVSRIYLDTILW 991  Aspergillus fumigatus
Q74ZM5  402 --LYVVEALEKR---DCYP---------ITCVRGYDTVYL--RQVLR---SGKSTPGAICK-PLMDIQLSLEQW 455  Eremothecium gossypii
Q5ATX5 1450 kiTHIIRGFAHKlsaEDAVn-------aVTDIYGHATLVVgpKQRKSltnSGLVGPENVINvPVSRIYLDTILW 1516 Aspergillus nidulans
Q6BNY6  643 kyKFVVTGLAYNkngDN-----------IKCIRGYNVVSL--RRISKg--KGKKFE-ELEA-SLSECYMELSDW 699  Debaryomyces hansenii
P14737  845 --EYVVVGLECRs-hDLNI---------IRCIRGYDTVHL--KKKNA---SGLLGKRTLIK-ALSSISLDLSEW 900  Saccharomyces cerevisiae ...
Q6FV45  609 --TGEIIALKCLs-eNSKD---------FRCVRGFDHVLL--KRLSG---NGKLGLEVFEM-PISDICMSIEQW 664  [Candida] glabrata
Q6CK71  568 --EYQVVALDCQipqKEDV---------IRCIRGYDTVHL--RKVLR---NGRLSKNDIVD-TIASIYVTTGEW 624  Kluyveromyces lactis
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