Conserved Protein Domain Family
eIF3_subunit

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pfam08597: eIF3_subunit 
Translation initiation factor eIF3 subunit
This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3). In yeast it is called Hcr1. The Saccharomyces cerevisiae protein HCR1 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p.
Statistics
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PSSM-Id: 400769
View PSSM: pfam08597
Aligned: 156 rows
Threshold Bit Score: 71.9601
Threshold Setting Gi: 298712135
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6BJ82         3 WDDEDFdipsnSKQAAA--------SWEE-EG-----------NDE-PLL------DSWDIDEEEVA-RKKKEEEAKKKA 54   Debaryomyces h...
EDQ89362     393 WDASDFe---aEAAEVEek-----pKWDD-EEpga------aePTTqELVpaskppSKYNDMDREEL-LQVIARLEAQGP 456  Monosiga brevi...
1_pfamImport   4 WDDDEF-----EVPPVTqpqi-spaTWDD-EEa----------EDE-PVP---------------------------AVK 38  
XP_002996949   4 WDDDEF-----EVPSVTetqk-vaaNWDD-EEe----------EEE-PVV----------------------------SA 37   Phytophthora i...
CBJ33014       5 WEDEEF-----DLPSSVppta-vpvSWED-EE-----------EDQ----------EDAGAVAPGLA-PKMSAAKAAKTA 55   Ectocarpus sil...
XP_002288012   5 WDDSDD-------------------DWDKsDDeldkrlglakiDDEkDAG------PVFNDEEEDLT-LQDKAADEKANQ 58   Thalassiosira ...
EEC45738       9 dD-----------------------EWDVdDDaldqklgmkkvAQNlPTF----------DDEEDLA-LKEKAAREQAEN 54   Phaeodactylum ...
XP_004364281   3 WDDEDEd----QGYKAVgkaaapagQWDD-ED-----------ADD-KVS------EAWDAEEDDDK-DKGGAAAATGAG 58   Capsaspora owc...
EFC38553     752 WEDAEId---dKPFSSTqtta-gddDWED--------------FDL----------DAVEKKQQEELkKKQEQ------- 796  Naegleria gruberi
KAE8969225     4 WDDDEF-----EVPSVTetqk-vaaNWDD-EEe----------E---PVV----------------------------AA 35   Phytophthora rubi
Q6BJ82        55 EKEalkK----KQEESKAKKLSKNKgq-------------rALLDIDLVDENTRQELLKKAELDADLNNAAD-LFGGLGv 116  Debaryomyces h...
EDQ89362     457 Tqk------kaPKKKKLKQILAEREaaeaar----aeelaqAEQELTPEERAAAKIVERRQVEESHMDAAKD-LFGGD-- 523  Monosiga brevi...
1_pfamImport  39 PELpaaTkalpKPKQLKKMKLKEIEekqkme----ialakaRLAAQTDETGEQRRAREKASIEEADFEMAID-AFAGAPs 113 
XP_002996949  38 KPEpavPkgplKPKQLKKMKLKEIEekqkme----ialtkaRLAAQADETDDQRRSREKASIEEADFEMAID-AFAGAPp 112  Phytophthora i...
CBJ33014      56 AEKdarIaaelETRLQLGETAEQ------------------------------RRLRERNRVEEADNDLTED-LFGGGG- 103  Ectocarpus sil...
XP_002288012  59 ALLktkGsalaKKKAAEKSQKEELEiarkam-----emeaeMEANMTPEE----RRQLAREREEADATAMTNdLFGAVDa 129  Thalassiosira ...
EEC45738      55 AELkkkGralaSKKQAEQERLEELEiarkam-----eleaeAMANLSPDE---LRRMKQRQVEEADNALTDD-LFGGVDa 125  Phaeodactylum ...
XP_004364281  59 AA----AapakKKKRSIHQAAAEREakeaeerkkmaekaaaAAEAAAAAERALTPAQRQRLVEQSDLDVAKD-LFGGDDe 133  Capsaspora owc...
EFC38553     797 ------LaeaeRQEKLKKQQQKEQKsnkka------etrttSSGNAPTGDKKVEGMYLDYMEKKTSYDEAEA-LIGGA-- 861  Naegleria gruberi
KAE8969225    36 KAEpaaPkgplKPKQLKKMKIKE-Qekqkme----ialtkaRLAAQADETDDQRRAREKASIEEADFEMAID-AFAGAPp 109  Phytophthora rubi
Q6BJ82       117 ageggmdinehpreraakaaaaaaaasgptPArLtKDTPIDTHPLF-QPTDRQEYEKLRKALAPVLTNLAeDSLmNYsSG 195  Debaryomyces h...
EDQ89362     524 ---------------------------------E-EEEEVVLFEAM-QPKTKEDFEKFARAIVKKARKYD-VSP-HY-LD 565  Monosiga brevi...
1_pfamImport 114 k----------------------------pAA-G-ATNDVDDNVSAfRLLSLADHEQFGDVVSTRLAASNs----KYaLE 159 
XP_002996949 113 k----------------------------pAA-G-ASDDADNAISAmRLLSLADHEHLGDVVASRLATSNa----KYaLE 158  Phytophthora i...
CBJ33014     104 -------------------------------A-R-GQGAGGGLSGL-ALKNMQDHVKLAIELAERMDS---SKPaHM-TA 145  Ectocarpus sil...
XP_002288012 130 ls--------------------------kgTS-AvPGGVMMSGDKV-VMKDLKDHLRHAKKVGECIQGHGkI---TLcSA 178  Thalassiosira ...
EEC45738     126 ka--------------------------gkGA-T-GGAAAAAGDKV-IMKDVKDHLKHARKVAECMQGHGkI---HLaAA 173  Phaeodactylum ...
XP_004364281 134 p---------------------------rkAA-KsNNNAGGILDAM-VPDTAAEFEEYGKALRKKFTSFEkSF--EF-AN 181  Capsaspora owc...
EFC38553     862 -------------------------------G---SEFAKPKIDLL-SPKTEKEFNEFGVLVADKLLEFEdSK--FY-LD 903  Naegleria gruberi
KAE8969225   110 k----------------------------pAA-G-ASSDADEAISAmRLLSLADHEHLGDVVSARLATSNs----KYaLE 155  Phytophthora rubi
Q6BJ82       196 LAIDLIRDLAQPLSIESIRKVVSTLNVISKEKEKAERQARlkkag---gtatgGAGKKKAKPAVKTN------------- 259  Debaryomyces h...
EDQ89362     566 FVDALFRDLLENASSEKIRQAIKSVNVLANEKAKTEKN------------------KKTKSKPKKAQiqasrgaassvag 627  Monosiga brevi...
1_pfamImport 160 CIKVILTKASVNLTADDMKEITTVVNVVKNEKIAAAKP---------------KGKKKKQIGKQGYAnv----------- 213 
XP_002996949 159 CIKVILTKASVNLTADDMKEITTIVNVIKNEKITAAKP---------------KGKKKKQAGKQGYAnve---------- 213  Phytophthora i...
CBJ33014     146 FLKELVTKLSPKMTADGLTDLVNHTTMFRDEKRQAEERIAsakanktnvianqRANKKKSIKKKKAHs------------ 213  Ectocarpus sil...
XP_002288012 179 FLTEVIQQCKDVLDDDAITEIIKSCNVIKNEKVQAAKRVKkg---------qaQKSKKADKQAAKKAm------------ 237  Thalassiosira ...
EEC45738     174 FFKELLQQSKDVLDDDAITEIIKTCNVIKNEKVQAAKRVTkvk-------gqaQKSKKADKAAEAKAl------------ 234  Phaeodactylum ...
XP_004364281 182 FFHAFVRDAAAGLPSDELRKLTATLNVLTNEKQKDEKGPA-------------KKGKPKKGPVKKIGldedf-------- 240  Capsaspora owc...
EFC38553     904 LVKRIVEEATINWDSAQLRELTKHVTNVSNKRMEEEKERK-------------AGGKKKKKTVNIER------------- 957  Naegleria gruberi
KAE8969225   156 CIKVILTKASVNLTVDDMKEITTIINVVKNEKIAAAKP---------------KSKKKKQTGKQGYAnve---------- 210  Phytophthora rubi
Q6BJ82       260 -----V--NTSFkqDVf-------------------Ddidq----skyDefeedDFM 286  Debaryomyces hansenii CBS767
EDQ89362     628 fldgdGygDDYG--DDl-------------------------------------DFM 645  Monosiga brevicollis MX1
1_pfamImport 214 -------------eRGvgssggkafagyedtyedglDd---------yD-----DFM 243 
XP_002996949 214 ------------rsVGnggaggmg----yagfedtyDd---------yD-----DFI 240  Phytophthora infestans T30-4
CBJ33014     214 ----dVfgGDFD--GDgidtv----------gmdyeSk---------yD-----DFM 240  Ectocarpus siliculosus
XP_002288012 238 ----eIheDVFGesNQy-------------------Deydem-ggayeD-----DFf 265  Thalassiosira pseudonana CCMP1335
EEC45738     235 ----qKqvETFG--AN--------------------De---------yD-----EYD 251  Phaeodactylum tricornutum CCAP 1055/1
XP_004364281 241 -------------------------------venpyDd---------aA-----DFM 252  Capsaspora owczarzaki ATCC 30864
EFC38553     958 -----DlsASADpfSDl-------------------GdgtggrtkyddD-----DFM 985  Naegleria gruberi
KAE8969225   211 ------------rnVGnggaggks----yagfedtyDd---------yD-----DFM 237  Phytophthora rubi
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