Conserved Protein Domain Family
RMI1_N

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pfam08585: RMI1_N 
RecQ mediated genome instability protein
RMI1_N is an N-terminal family of eukaryotic proteins. The domain probably carries an oligo-nucleotide-binding domain or OB-fold, and forms a stable complex with Bloom syndrome protein BLM and DNA topoisomerase 3-alpha.
Statistics
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PSSM-Id: 400758
View PSSM: pfam08585
Aligned: 101 rows
Threshold Bit Score: 118.139
Threshold Setting Gi: 74832533
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:MYCTH_116885  11 LSTTsIPVPSLAWLEALAGARSpa-------ppLASLLATARARLLASDLTAPgll--darYAAAHSLPARlaqthagtr 81   Thermothel...
CAP23335          10 FAKK-HMQLKAAWLKTCIEFLKrtvns--eiqsSDAICDQVMLQFLYSNLSDS--------LVPVMKIPDHaa------k 72   Caenorhabd...
XP_003111476      13 LAQK-HLPLKLEWLKICIKYLEksvda--nmrrSLKMFDLVMQQFLNSKISDT--------LNPVMKIPINas------k 75   Caenorhabd...
EGT38899          13 FKRK-HIPLKSEWLKICIEYLEqnlgk--klplSEETLNLVIQQFLHSNLSES--------LNPVLKIPTNav------k 75   Caenorhabd...
4_pfamImport       1 LAKK-HYTLKKEWLKTCVEFLEvrlge--klqsTEQLMHLVIHQFLNSEISTT--------LSPVMNIPTGav------k 63  
P91399            13 LARK-HYPFKREWLRICVQYIEgslgqriktvdVKQIGELVIQQFLNSKISEA--------LDPTMKIPTSav------k 77   Caenorhabd...
PDM80685          14 FLEN-HILLRDDWVKAVLNFALqkfp----tysGRRLYNLLFEQWLYSNLSES--------C--YPTLEGIdaqa----r 74   Pristionch...
CAP36665          12 FGDR-HILLKEEWLNSVIDFLHnhvpl-srdfdNETFANIVLDQWTCSNIESTsfpafgnhG-----IDSSiqk------ 78   Caenorhabd...
CDP90636          10 FSEKlNVTLHEEWLTEVMKYLYslg------fsSNSLLSSVYEQWLYTNLKIS--------TKPLLSLSADncsk----- 70   Brugia malayi
ETN67000          16 FVREfNIKVIDEWLTGCVSFCLqenp----qttNESLFEFAFSQWLLADLREI--------G--VAVLPTGfnsrt---e 78   Anopheles ...
jgi:MYCTH_116885  82 eAALPHDVVv--------------QVLDVEDVARSRWEQVEALEAlergegtrgreiirlNTassssssssgadgtaega 147  Thermothel...
CAP23335          73 vILVKKMVF---------------QVVTYVNISVSLFEQLSECTR---------------HN------------------ 104  Caenorhabd...
XP_003111476      76 vMIVKRMVF---------------QITSYTNISVSLYEQLSVCTR---------------HN------------------ 107  Caenorhabd...
EGT38899          76 vIIVKRMIFevpfitflnpqmlvvQMTSCTNVSTSLYEQLSECTR---------------HN------------------ 122  Caenorhabd...
4_pfamImport      64 vFIVKKMIF---------------QMTSYLNVSKSVYEQLTECTQ---------------SN------------------ 95  
P91399            78 vVIVKRMIF---------------QVISSTNISTSLYEQLSECTR---------------HN------------------ 109  Caenorhabd...
PDM80685          75 tidVHQPLVl--------------QITSLIDIGTSLLSQFNKLTY----------------------------------- 105  Pristionch...
CAP36665          79 -qhLQGPIVc--------------QVNGFIDTGSPYYQQYCNLNRs---------------------------------- 109  Caenorhabd...
CDP90636          71 rmmLGGNTVv--------------QVNSVVDIGTSMYSQYRNLTN----------------------------------- 101  Brugia malayi
ETN67000          79 qytLNGSFPi--------------QMHQLIDISESAYDQWRKMYD----------------------------------- 109  Anopheles ...
jgi:MYCTH_116885 148 eeEEeeeg-gnaaAGAGGGGggggrggatstsnnnnnnnssssSSSSKNGTHKLVVQDCkGQKVHAIELKRVERLGVgrT 226  Thermothel...
CAP23335         105 --DDlswf-hggaELHDDRNlekdhtc---------dknnnmrVIPKKRGMLKLEITDG-QNKLEAVELEDVFDESL--L 169  Caenorhabd...
XP_003111476     108 --EDlswf-hggsNMHHDEEnretekdtif---qaadknnnfrPIPKKRGMFKLEITDG-LNTVKAIELEEIFDETL--V 178  Caenorhabd...
EGT38899         123 --EDlswf-hggsKMIPDESnrekeedttfn-nqvddnnnkkrTIYKKRGMLKLELNDG-VNSVKAIEIEEVFEEEH--L 195  Caenorhabd...
4_pfamImport      96 --DDlkwfhggfsKFQDDEEngekdtladq----nnnkemswkKTEKKRGILKLELTDG-VNKVKGLELEEIFDEKL--L 166 
P91399           110 --EDlawf-hggsKADHEEEnrdkekdvas----drmnhtqtkNAIKKRGMLKIELTDG-VNTLKAIELDEVFDEKI--M 179  Caenorhabd...
PDM80685         106 -------------EFMDNSGfdidpnd----------qkednlYQPKPSRCLMLTLSDG-EKELKGMERRHIPSLSLl-T 160  Pristionch...
CAP36665         110 ------------gKKEDNSGfekvfh------------ekeddSDQKPSRLLKLSLTDG-ESFLNAIEFWKCPQLSLh-C 163  Caenorhabd...
CDP90636         102 -------------KFEDNSGfqlkmee----------netntdPFQNAKRMLSMEVTDG-QLSMKAVEYSMLSALSLl-T 156  Brugia malayi
ETN67000         110 -------------KKLDEADdevqm-------------rknqtQHTKKRRMLKLELSDG-KQTVTAMEHSPIRCLNTk-L 161  Anopheles ...
jgi:MYCTH_116885 227 FIGEKILLRaGTVLARGVVLLDPAHCVVLGGKVESWHRAWLDGR 270  Thermothelomyces thermophilus ATCC 42464
CAP23335         170 VPGVKILLTgSVKCRRGILLLEKSNCDLLGGRVDSLKIDKVTQL 213  Caenorhabditis briggsae
XP_003111476     179 VPGSKILLTgSVKCRRGVFLLEKSNCMFLGGQIESLHIDKIKQL 222  Caenorhabditis remanei
EGT38899         196 VPGVKILLTgRVKCRRGTLFLEKSNCSLIGGRIEALKFDKVKQL 239  Caenorhabditis brenneri
4_pfamImport     167 IPGVKIMLTgKVKCRRGTLLLDKSNCQILGGQVDSLKFDKIKQW 210 
P91399           180 LPGAKIILTgKVKCRRGNLLLDKSNCAFLGGRVESLSFDKVAQL 223  Caenorhabditis elegans
PDM80685         161 TPGCKVVLRpPLVCRKGVFLLTPQNVQVLGGDEPNLMETGRPLN 204  Pristionchus pacificus
CAP36665         164 KPGTKLLIEpPCDIRRGTFLLKPGNCRILGGEVLPLLNCHLPVE 207  Caenorhabditis briggsae
CDP90636         157 CPGCKILLTnNVCIRRGILLLTELNCIVLGGDDESLMKTGRPVE 200  Brugia malayi
ETN67000         162 APGSKILLSgPLRCINSVLFLEPKNVRLLGGEIDVLLIDNAYEN 205  Anopheles darlingi
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