Conserved Protein Domain Family
Cmc1

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pfam08583: Cmc1 
Cytochrome c oxidase biogenesis protein Cmc1 like
Cmc1 is a metallo-chaperone like protein which is known to localize to the inner mitochondrial membrane in Saccharomyces cerevisiae. It is essential for full expression of cytochrome c oxidase and respiration. Cmc1 contains two Cx9C motifs and is able to bind copper(I). Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase.
Statistics
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PSSM-Id: 400756
View PSSM: pfam08583
Aligned: 46 rows
Threshold Bit Score: 47.7215
Threshold Setting Gi: 122176710
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9NRP2     1 MHPDLSPHLHtEECNVLINLLKECHKNhNILKFFGYCNDVDRELRKCLKNEyvenrtKSREHGIAMRKKLF 71  human
Q0IF43    42 IPKIMRERAKtEKCIPEVQDFETCCKD-SGLLMAMKCQKQNEALKTCSLRWyndeqfKSECTEIYLAERSE 111 yellow fever mosquito
Q4RFB6    20 IPKLMREKAK-ERCAEKVEAFTHCCKE-SGFFMVFKCREENTAMKECLTAHykdpsfFEECKQEYIEEKLE 88  spotted green pufferfish
Q9CPZ8    19 IPKIIREKAR-ERCSEQVEDFTRCCKD-SGILMVLKCRKENSALKDCLTAYyndpafYEECKLEYLKEREE 87  house mouse
EDO46283  10 IPKLVREKAR-ERCKDLVDEFEKCCKG-RSISMVWHCRKQNTAMKDCLTKNyqdkelFEACRVEYLQKRRQ 78  starlet sea anemone
Q6C7C2    42 VREETRRLAR-IACADVLKVFSDCTKG-RTVSMLWACRIEKANMMECMASHstm-edfDRARDEFVQKKAD 109 Yarrowia lipolytica
Q5KJR5    12 IHEAAKKEAL-RSCDDYVKDFADCATG-RTFSLPFMCKTRLNAMQGCMRDYmtq-ermDAMKLDFIAHRSE 79  Cryptococcus neoformans
EDN05756  40 VRDLYYKRVR-GHCAAEIKEFAACAIN-RTVTATWVCRKQRLAMNACMVEHakp-eeeDRAREEWFTSREE 107 Histoplasma capsulatum NAm1
EDO03439  35 VQEVYHTRVR-SYCAAEIKTFAECALG-RTFTAPFKCREQNRAMNNCMITHatq-sekDAAREEWFSLRLQ 102 Sclerotinia sclerotiorum 198...
Q7SDV5    52 VRDIFYARVR-RQCTEEIKAFAECALG-RTFSVPFACRAPHRVMNNCMKLHatp-aeqDAAREEWFALRME 119 Neurospora crassa
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