2RNR


Conserved Protein Domain Family
PH_TFIIH

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pfam08567: PH_TFIIH 
TFIIH p62 subunit, N-terminal domain
The N-terminal domain of the TFIIH basal transcription factor complex p62 subunit (BTF2-p62) forms an interaction with the 3' endonuclease XPG, which is essential for activity. The 3' endonuclease XPG is a major component of the nucleotide excision repair machinery. The structure of the N-terminal domain reveals that it adopts a pleckstrin homology (PH) fold. This PH-type domain has been shown to bind to a mono-phosphorylated inositide.
Statistics
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PSSM-Id: 400744
View PSSM: pfam08567
Aligned: 93 rows
Threshold Bit Score: 56.8655
Threshold Setting Gi: 443898181
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2RNR_B                 18 RQK-----K-QDGALYLMAERIAWAP------E-GKDR-FTISHMYADIKCQKISPEGKAKIQLQLVLH----------- 72 
2_pfamImport            1 RVK-----K-RDGRLELSPKGLRWTAdv---sPdTPSPhAPIVVPWSTVQGQQVSSLSSPKAMIRLRLA----------- 60 
EED94215               18 IYR-----K-TRGTLTLTERGLLFKPegntaaDaSSSSsTSVVLPWTQIEKHQVSPASHAKHLLKVIASsss-------- 83  Thalas...
EEF31761               11 KYKtslkdPgTPGRLLLTMEKLAFRP------NnPNSA-SKLDMDFKYVTNHKNTKEGSAKAMLNLTSN----------- 72  castor...
Q55FP1                 19 KYS-----S-QQGTLFFTSLRLVWV-------QsGYSE-PSLHLHISEIKNQFISTPKSAKALLRLSVRdsi-------- 76  Dictyo...
EFA80616               19 KFA-----K-EAGTLYCTNMRLVWV-------QsGKIE-PSLHFHFSEIKTQFVSTSTSAKALLRLSVKdek-------- 76  Hetero...
XP_004362575           19 KFN-----K-EQGTLYCTNLRIVWV-------QlGKNS-ASLHFHLSDIKTQFISTEQSVKALLRLSVKeqr-------- 76  Cavend...
CBN75654               21 VHK-----K-TPGTVWFTSRRALWKA------AdGKAAvQRVEVAWAAVKSFQCSPASEARAMMRLLRVt---------- 78  Ectoca...
WGS:AACS:CC1G_03201    11 SYK-----K-LPGLLELTDTHLQWT-------QdGKKQ-PAIRVAHAEAASLFSSKEGAEQVRLKIVLVn---------- 66  Coprin...
WGS:AAWC:PGTG_09050.3  17 IYK-----K-KTGKLLLTNSVLKWIPk----dGaGSGA-EVVSIDFPRLHSLFSSREGGPKVILKIVAKaistsptptdg 85  Puccin...
2RNR_B                 73 -------AGdTTNFHFSN--ESt--AVKERDAVKDLLQ 99 
2_pfamImport           61 -------HNsTLVLEFVAncGNmeeAFQVRERAKDFIA 91 
EED94215               84 ----ptnTStSYTFAFLT--------RNGLESARRDIT 109 Thalassiosira pseudonana CCMP1335
EEF31761               73 -------QGvSYIFEFEN--------HDDLRICKEIVG 95  castor bean
Q55FP1                 77 -----knALqEFVFEFTH--PTn--ARSDLNSFRDKIA 105 Dictyostelium discoideum
EFA80616               77 ----dsnATqDFLFEFSH--MSn--ARQDLNKFKERIG 106 Heterostelium album PN500
XP_004362575           77 ----dsiQTkDFLFEFIH--GQd--ARKDLNTFRDRIA 106 Cavenderia fasciculata
CBN75654               79 ------eGQpPIIFRFTEtpGGt--PREVLERAQAAVR 108 Ectocarpus siliculosus
WGS:AACS:CC1G_03201    67 -------nPnGHTFAFTNqpQSv--AYQERERFKTELT 95  Coprinopsis cinerea okayama7#130
WGS:AAWC:PGTG_09050.3  86 snptstgEE-TYNFAFTS--SD---PLSDRETFKKHIS 117 Puccinia graminis f. sp. tritici CRL 75-36-700-3
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