2A05


Conserved Protein Domain Family
Crisp

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pfam08562: Crisp 
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Crisp
This domain is found on Crisp proteins which contain pfam00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK.
Statistics
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PSSM-Id: 400739
View PSSM: pfam08562
Aligned: 68 rows
Threshold Bit Score: 49.5341
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2A05_A         3 CASCPNNC-ENG--LCTNSCDFEDLLSNCESLKTSAG---CKHELL-----KTKCQATCLCEDKIH 57  house mouse
XP_012549927 207 CSDCPDHCtSES--LCTNFCPVRDYYSNCDELVKNIDg-fCK---------QGMCNATCSCGSKll 260 domestic silkworm
XP_016766808 208 CTMCNEHCsRNK--LCTNACHHVDLWSNCVELARMFRswvCETNTSegrerRKFCGATCNCEGKIY 271 honey bee
XP_008207720 215 CSACGGHCrLGK--LCKNACPWADLWANCQQLRATWPgwlCDTDTEqgrerRQFCRATCRCDGKII 278 jewel wasp
EFX86285     224 CGRCKGSCkLRK--LCTNSCSYADLWVNCRELNTTWNqwlCHNNSKegldrKKHCRATCECTGKIY 287 common water flea
9_pfamImport   1 CSSCAQHC--RKgkLCTNNCDGVDLWFNCREIHRTWPqwlCESDGAkglerKQNCAATCNCKGKI- 63 
ETN60767     228 CGSCQSHClSRKtrLCTNICSTADLWANCRELHRTWPgwlCNTATPeglerQRNCAATCTCQGKIH 293 Anopheles darlingi
XP_019698612 208 CSECKDHCvQEQ--LCTNACYYTDLWSNCAELVRTFDswvCETNTKegrerRKFCGATCNCKDKIY 271 Jerdon's jumping ant
XP_001846484 204 CSSCHQHChSKKikLCTNTCSSADLWANCKELYKTWPgwlCNTVTLeglerQRNCLATCTCQGKIH 269 southern house mosquito
XP_015202638 182 CGDCPNDC-EDG--LCTNPCEQFDKAGNCKVLMQLKNa--CENPLI-----SSWCAASCQCGKKIY 237 spotted gar
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