2OFP,3G17


Conserved Protein Domain Family
ApbA_C

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pfam08546: ApbA_C 
Ketopantoate reductase PanE/ApbA C terminal
This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.
Statistics
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PSSM-Id: 400727
View PSSM: pfam08546
Aligned: 80 rows
Threshold Bit Score: 58.3895
Threshold Setting Gi: 500047969
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2OFP_A        185 NIRAELWRKLAVNCVINPLTAIWNCPN-GELRHHPq---EIMQICEEVAAVIEREGHH-TSAE--DLRDYVMQVIDA--- 254
Q122Z9        201 NIMGTIWDKLLINVATGALTGITRLTY-GQLYRQPeleaCGVAAVAEAMTVAEASGIR-LSIT--DPRDAWLKAGAG--- 273 Polaromonas sp...
jgi:Pnuc_1541 182 QIKRDMWLKFLVNCSYNGISGIGQITY-GEMVRVPeiiqQIDGITHEFIKIAALEGVL-ISEA--EGREANELIAST--- 254 Polynucleobact...
Q24N79        177 NLIGTRWSKWTSNCCFSGMSAVVAGTF-GDVLDNPhairCSAHILNESMAIAKAAG---VTPEpfQGDDYAALAFTTeke 252 Desulfitobacte...
WP_011777231  182 DMLQAALMKFCRVSAISGAMVYYNAQL-GEIKKDPekteFMIGLCKELIALGETSGHP-FPPE--FDAVEDLRYIVA--- 254 Paenarthrobact...
XP_001289962  196 LAIPDRWKMLLYYPANIAVSAVVNLDF-STCWNCEplqkVLEKLGEECAQIAELEG---VDTK--FFNKEIAVEAVKkla 269 Trichomonas va...
Q9Y7P6        206 KIQKKQWETGVGHMCFYPLSIINDEPNlALMYRLKsfakVIDGLMDEAFSIAQAQGCEfEPEKldVLKRHIVNRMLA--- 282 Schizosaccharo...
XP_001539595  199 NIRQEQYERMIGPIAFYPASVMFECPNhADLLEKVglrqLISGVIDELLSLAKAQGCT-FPEK---FNETIIEKMIS--- 271 Histoplasma ca...
EDK34220      178 DMMHSLWWKFMINVGINQASAVIKGTY-GVFQKVKeareLMESAMWEVVKLSEKVGVN-LDKG--DIDKWYKVLDTM--- 250 Clostridium kl...
WP_021944081  177 DMLKGLWFKYMCNIGENMTCALLGIPF-GFFRISDsanwIRDNAMREVAAIAQKKGID-IGEK--EIAEQDVTVMTI--- 249 unclassified C...
2OFP_A        255 -------TAE-----N--ISSMLQDIRALRHTEIDYI-NGFLLRRARAHGIAVPENTRLFEMVKR-KE 306
Q122Z9        274 -------LPDe----F--KTSMLQSLEKGSVTEIDFV-NGSVVRWGAKCGVPTPVNQALVACIKG-IE 326 Polaromonas sp. JS666
jgi:Pnuc_1541 255 -------MVT-----Q--RSSTAQDLARGKKTEIDFL-NGYIVQLAKKYGVEVPYNQSVYALIKM-LE 306 Polynucleobacter asymbioti...
Q24N79        253 leanipgLKAcveshRniRTGMLYDIEAGRYPEIDTTyNGVQCKLGAKYGVPTPVNQQVVDIVHQmAE 320 Desulfitobacterium hafnien...
WP_011777231  255 -------AAP-----DdyRTSLMYDYLADRPVEWRTM-FQDPYLMGRRFGLEMPSYGKVCE--VFdLE 307 Paenarthrobacter aurescens
XP_001289962  270 ----leeCPK-----H--QGSMNQDVFNQRKTEIEAT-AGVLLKLAEKHKVELPYTHTIYALIRA-KE 324 Trichomonas vaginalis G3
Q9Y7P6        283 -------TPR--------PSYPYQDYIAHRPLEVAVL-LGYPVEIAKELGVSVPRMETLLALFDA-KN 333 Schizosaccharomyces pombe ...
XP_001539595  272 -------HSD-----N--PSTMYQDWLARRPMEVETY-LGSPIKLATEIGIKIPRIETLYAMLHH-LN 323 Histoplasma capsulatum NAm1
EDK34220      251 -------NPS-----S--KTSMFQDITYGRKTEVDMF-AGTVCKLGKKYDMDTPVNKTFLNIIKV-VE 302 Clostridium kluyveri DSM 555
WP_021944081  250 -------PPE-----N--KPSTLQDLEAEKLTEVEMF-AGNVIKMGKELGVPTPINEMFYHGIRV-Le 301 unclassified Clostridium
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