5Y31


Conserved Protein Domain Family
ADAM_CR

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pfam08516: ADAM_CR 
ADAM cysteine-rich
ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour. It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity.
Statistics
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PSSM-Id: 400700
View PSSM: pfam08516
Aligned: 351 rows
Threshold Bit Score: 63.5741
Threshold Setting Gi: 675847716
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Y31_A       299 DGYSCDGvQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYeKLNIEGTEKGNCGk-DkdTWIQCNKRDVLCGYLLCTNIG 377
XP_019827494 504 DGSPCARgRGYCRDGACPTLEQQCQQLWGPGSRPAPEACFqVVNSAGDAQGNCGqqGdgNFVPCARRDAQCGKLQCQGGE 583 zebu cattle
AAX55227     362 DGSPCAEgRGYCLDGWCPTLEQQCQQLWGPGSKPAPEPCFqQMNSMGNSQGNCGqdHkgSFLPCAQRDALCGKLLCQGGE 441 house mouse
EDL80220     506 DGSPCAEgRGYCLDGWCPTLEKQCQQLWGPGSQPAPEPCFqQMNSVGNSQGNCGqdSkgSFLPCTQRDAQCGKLLCQGGK 585 Norway rat
XP_007482077 506 DGEPCAGgKAVCAAGHCASYVAQCQALWGPGARPATPFCLqAANTRGDSFGNCGkqNngSYVPCAPRDASCGQLQCQGGG 585 gray short-tail...
XP_008262584 527 DGEPCAGgQAVCVHGRCASYTQQCQSLWGPGAQPAQPLCLrTANTRGDVFGSCGrsPdgSYVPCTPSDAICGQLQCQGGG 606 rabbit
XP_012904406 499 DGEPCAGgEAVCVQGRCASYAQQCQALWGPGAQPAPPPCLlAANTRGDAFGSCGrsAngSYVSCAPKDAVCGQLQCQGGQ 578 domestic ferret
XP_023409803 508 DGEPCAGgQAVCMQGRCASYAQQCQALWGPGAQPAAPLCLrTANTRGDAFGNCGrnPn-gYVSCAPQDAICGQLQCQGGR 586 African savanna...
XP_017821811 509 DGEPCAGgQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLqTANTRGNAFGSCGrsPsgSYESCSPRDAICGQLQCQTDR 588 white-tufted-ea...
O88839       509 DGEPCASgEAVCMHGRCASYARQCQSLWGPGAQPAAPLCLqTANTRGNAFGSCGrsPggSYMPCAPRDVMCGQLQCQWGR 588 house mouse
5Y31_A       378 NIPRLGELdgeitSTLVVQQGR-TLN-----CSGGHVK--LEEd-vDLG 417
XP_019827494 584 QSALVPHVvp--vDSTVHLGSR-EVT-----CRGASMLpgAQLdlpDLG 624 zebu cattle
AAX55227     442 PNP-LVPH-----IVTMDSTILlEGRev--vCRGAFVlpdsHLdqlDLG 482 house mouse
EDL80220     586 PNP-LVPH-----VVTVDSTILlKGRqv--lCRGAFVlpdtHLdqlGLG 626 Norway rat
XP_007482077 586 AHPLLGTA-----QDTLTETVEvNGTrq--tCRWTHLd--lGSdvaQPF 625 gray short-tailed opossum
XP_008262584 607 ARPLLGSA-----RERLWEMVEaNGTql--nCTWVHLd--lGSdvaQPL 646 rabbit
XP_012904406 579 ARPLLGTA-----RDLRWEVLEaSGTqpsvnCRWVHLd--lGDdvaQPL 620 domestic ferret
XP_023409803 587 AQPLLGSA-----RDLIWEMLEaNGTqm--nCSWVHLd--lGNdviQPL 626 African savanna elephant
XP_017821811 589 TQPLLGSV-----HALIWEMIDvNGTgl--nCSWVHLD--LGNdvaQPL 628 white-tufted-ear marmoset
O88839       589 SQPLLGSV-----QDRLSEVLEaNGTql--nCSWVDLd--lGNdvaQPL 628 house mouse
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