Conserved Protein Domain Family
Vfa1

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pfam08432: Vfa1 
AAA-ATPase Vps4-associated protein 1
Vps Four-Associated 1, Vfa1, in yeast, is an endosomal protein that interacts with the AAA-ATPase Vps4. It would seem to be involved in regulating the trafficking of other proteins to the endocytic vacuole. There is a CCCH zinc finger at the N-terminus.
Statistics
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PSSM-Id: 400642
View PSSM: pfam08432
Aligned: 88 rows
Threshold Bit Score: 91.6183
Threshold Setting Gi: 384490105
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCK69965       3 NEYIKRRVATKDSQLCMICQKPTTTVLFNQSGq-----DWIYTCELHLQNnPQFVTPSYSQeYHDAVENCKNNREALTKL 77  Kazachstania na...
XP_002553775   3 NQYTKRKVAPRDARSCLVCLKPTACVLYNASIq-----DWFHCCELHLQDnPQFAKPVYPAgYQDALGQLAELKRTLDAQ 77  Lachancea therm...
EDO17805       3 NEYVARQVALKDTQPCIICSKPSTTVLYNGSGp-----DWFYSCNIHLVDnPQFVVPMYTQeYYSSLEELKRLKQESNSL 77  Vanderwaltozyma...
CCH60729       3 NEYVKRKVALKDIQPCLICNKPSTTVLFNGDNnngggaDWFYVCDIHLQDnIQFVVPVYSKeYENEVIHLRQLKQKITST 82  Tetrapisispora ...
XP_002498808   3 NEYTARKVGIKDMQPCVVCYKPTTTVLY--SGi-----DWFYTCDIHLQDnPQFVTPLYSKeYQDAVAKLKALKPLPATN 75  Zygosaccharomyc...
CCD23284       3 NEYVSRKVSLKDINGCLICQKPTTTVLYNKSGp-----DWFYTCDIHLQDnPEFVKPIYGKdYETKTNRLKSVQQELHRI 77  Naumovozyma dai...
XP_003674913   3 NEYACRKVALRDTKSCLVCHKPSTTVLYNKSGp-----DWFYTCDIHLQDnPQFATPVYDKeYENVLTKMKSLKNELNSN 77  Naumovozyma cas...
XP_003648485   3 NVYTKRKVSAASASTCLVCLKPTTTVMYNKSGq-----DWFYCCDLHILDnPQFAQPIYTShYKERLKRVNELGAKLGSH 77  Eremothecium cy...
Q75CH1         2 DKYAKRKVAARDAGGCLICDSRTVTVLHCAASg-----DWFFCCDLHLQDnPQFAQPNYTPaYHAACRRVADLASRLAAS 76  Eremothecium go...
Q6FN74         3 NDYTRRKVAVQDTQACYLCHKPTNVVLYNQSGp-----DWFYTCELHLQNnPQFAVPVYGAeYESILKKMKETKELLNKQ 77  [Candida] glabrata
CCK69965      78 KNNNStDSSSWdtwvnrlftkkQENdkakpkeseilNSELPTNTRDDKGSNPTNpakspdiqsqINDLQGQYDAALEKML 157 Kazachstania na...
XP_002553775  78 RVHGS---GSWdtwvnklisrkPKSendkdkepgkePSKDPDEEPGKGSDKEPSp--------aGDDAACAYQQALDRVA 146 Lachancea therm...
EDO17805      78 TQEDL---SSWdgwvtkifnkkPKE-------------DSKEKEKEKEQEKVKEkestesvvdrSSELKNEYRKALDRLS 141 Vanderwaltozyma...
CCH60729      83 AAIKN---GNWdgwvtklfakgTKSstktdnieadsAIDADNEDKGTKGQDTKApa-------dLSALQREYDETLDRIT 152 Tetrapisispora ...
XP_002498808  76 SG------SGLdgwvskflkkdKKEk---------hNGGDGDGNGDGDGDGEKTtkd----kdqGQELQRQYDEQLDLVS 136 Zygosaccharomyc...
CCD23284      78 QKNND--PSSWdgwvgklfikkNKNqs-------pdKDKDKDKDENKDGDNNNNkvgnestgnrSDMLQREYQTLLDELT 148 Naumovozyma dai...
XP_003674913  78 AGASG---SSWdswvskvfikmD---------------KDADKPKDTDPANTPEpav-----rtQAQIQEEYNATLDTLT 134 Naumovozyma cas...
XP_003648485  78 SATHS---GNWdswitnlftsaKVApp--------eTKSQPNSEKPPADPADAEpk------etLSQLKLQYDKELSAVA 140 Eremothecium cy...
Q75CH1        77 EKAAA---AGWdswlgrfaaskKKPavpakdgnvsaQGQDKTEDKEEKPAEVSAa-----------DLRREYERELATVA 142 Eremothecium go...
Q6FN74        78 VTSKG-GVGNWdgwvnklissrKS--------------KDDDKEADKKDDQKDDtqda---erqEPDLQKQYDMLLDKLT 139 [Candida] glabrata
CCK69965     158 TLQKSNksFKLSDKMFALRLENRrekqrAQERKRREEENYSNtDPEQmqs-qfsFPEVPK 216 Kazachstania naganishii CBS 8797
XP_002553775 147 RYRKNLrtYSLSQIMFESRLEAQkraeaLKQRRQREQEAYTNtDPDElqa-kfaFPSVPR 205 Lachancea thermotolerans CBS 6340
EDO17805     142 ELQKKNkkYKLSQIMFESRTQLKqkqaaIAELKRKEAESYTNtEPDElln-kysFPDIPN 200 Vanderwaltozyma polyspora DSM 70294
CCH60729     153 KLQKNNktYQLSDTFYQSRLERKkqqekLAARRKQLQESYTNtDPDElls-kfaFPSVPK 211 Tetrapisispora blattae CBS 6284
XP_002498808 137 KLQRQNrkYQLSRTVFDSRIQRKqmetkWKEQKRIEDESYTNtDPLElet-kfvFPSVPK 195 Zygosaccharomyces rouxii
CCD23284     149 HLKQNNrkYQLDNSLYENRVQRR-------IRTQRIKETYTAtNPEElaqrlatFPNVPT 201 Naumovozyma dairenensis CBS 421
XP_003674913 135 TLRKKNkmYQLSPQMFESRVQLKkreemLKEQRRKQEEAYTNtDPDEllt-kfsFPQVPN 193 Naumovozyma castellii CBS 4309
XP_003648485 141 DIKKNTrtYSLSQVMFESRQQRLkhlsnVKEQNRMHQEAYSNtDPEDllk-rynFPELPK 199 Eremothecium cymbalariae DBVPG#7215
Q75CH1       143 TLRNKPatYTLSAVMLTSRLERRtrvaaRAERAREEEQAYSNtDPQQllq-tyhFPELPK 201 Eremothecium gossypii
Q6FN74       140 EIKSKNkkYKLSDMMFQNRVDLKererlRRIRIQKEQEQYSNtDPVElet-kfqFPSIPQ 198 [Candida] glabrata
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