Conserved Protein Domain Family
NRDE-2

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pfam08424: NRDE-2 
NRDE-2, necessary for RNA interference
This is a family of eukaryotic proteins. Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that regulate heterochromatin formation, developmental timing, defense against parasitic nucleic acids, and genome rearrangement. Many small regulatory RNAs are thought to function in nuclei, and in plants and fungi small interfering (si)RNAs associate with nascent transcripts and direct chromatin and/or DNA modifications. This family protein, NRDE-2, is required for small interfering (si)RNA-mediated silencing in nuclei. NRDE-2 associates with the Argonaute protein NRDE-3 within nuclei and is recruited by NRDE-3/siRNA complexes to nascent transcripts that have been targeted by RNA interference, RNAi, the process whereby double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA.
Statistics
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PSSM-Id: 400637
View PSSM: pfam08424
Aligned: 103 rows
Threshold Bit Score: 175.586
Threshold Setting Gi: 124460105
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KJE91902      587 RLNEFVRLHPRNVDGWMRLVEFQE-TLLslhsggfasfFQQSaqttgksqatgkaqAWnrssapRMA--VAEMQLAILER 663  Capsaspora ow...
XP_004997320  371 EFNAALRRHPEDTTMWRTYIDFQD-DVFav----------eAgh----------srKA------VAL--LIDRKLALYDE 421  Salpingoeca r...
XP_003385086  315 DYNRRL-AGTNDVSLWLEFIAFQD-QLLhwgvspsgdgEDKGvgee-------rkkKL------KAA--ITERKISIYEK 377  Amphimedon qu...
A0DU55        113 ELQNQLQTNVNDLDIWKEFLLIQEkIAElqg------------------------------ynePLL--LANRRLSILQK 160  Paramecium te...
EFA79562      338 ELNSAVERSPNDIDRWIELADYQD-----------------Hf------------lVFstkrsqRARipIVEKKLSIYRS 388  Heterostelium...
XP_003292652  344 ELNYKVEQNPTDIDRWLDLVKFQE-----------------Nf------------qQFsak-ksRSKfsMYDRQLTIYKN 393  Dictyostelium...
Q54QP0        356 ELNKLVEQYPNNIEYWIDLVKFQE-----------------Nf------------qQFsrn-vnKSKtsMYEKQLSIYRN 405  Dictyostelium...
ERN11072     1513 EFNKMSRDFPHDEKVWMAFADFQD-KIAs------------Tqs----------kkGA------RLQ--VLEKKISILEK 1561 Amborella tri...
XP_003549192  304 EFNKLTREHPHDEKVWLAFAEFQD-KVAg------------Mqr----------qkGA------RLQ--TLAKKISILEK 352  soybean
Q9LSH4        280 EFNRVTRERPHDAKAWLAFADFQD-KVSs------------Mqs----------qkGV------RLQ--TLEKKISILEK 328  thale cress
KJE91902      664 ALREN---PASPELARRYLSLGHEL-WPSA---K-LAEQWERIIF-------------------QFS-THLVMWREYLLF 715  Capsaspora ow...
XP_004997320  422 ALKHN---PHDEDLFIGYLELCAQK-MTPD---D-LEAKWTRTLF-------------------LHP-NKHRLWQRYLAH 473  Salpingoeca r...
XP_003385086  378 ALGIF---PYSTDLIIGHMELVEEI-WDTE---K-LVEKWKDIVF-------------------YNS-NQSLLWIKYIEF 429  Amphimedon qu...
A0DU55        161 LEQVSevlADHPWVLAYKISLMQNLeLRNDelhKeIDNCWSELFS-------------------KYV-HIQPIWILFLDH 220  Paramecium te...
EFA79562      389 ALAMN---PDSDELTIRYLRLAQEI-WDSE---Q-VRQLWSRVIErrsleysa---assssssnVDDlISEDLWREYTSF 457  Heterostelium...
XP_003292652  394 ALMAN---PDSERLTIEYLKLASEI-WDQE---R-VLNLWNALIQkstqdfldyqqqvhsqhqaHPTiISEDLWREYINF 465  Dictyostelium...
Q54QP0        406 SLLHN---PDSEILTIEYLKLASKL-WDQQ---K-VLDLWNKVLSsss-------------sssSSSiISEKLWKEYIEF 464  Dictyostelium...
ERN11072     1562 AMELN---PDNEDLLICLMKAYQSR-DSTA---V-LVERWERTLV-------------------QHS-DSCKLWKEFIHF 1613 Amborella tri...
XP_003549192  353 AVELN---PDNEEILLCLLKAYQMR-DSSD---V-LIARWEKILL-------------------QHS-GSYKLWREFLHI 404  soybean
Q9LSH4        329 AFELN---PDSEELLLALLKAYRSR-DNAD---V-LISRWEKALM-------------------QNS-ASYKLWREFLCV 380  thale cress
KJE91902      716 CQSHVATFSMATCLSGYRKCFSTLSGINERTIReTLAvAetaaptlaaatiaiQRDLLDITSQLCDFLRDSGCPEKAVAL 795  Capsaspora ow...
XP_004997320  474 STALLARFTVSSCQSKFHKCIETLDGLKEGSFAtHHLdKdv-----------aEETLLDVVFESCHFQAKAGCMERAIAC 542  Salpingoeca r...
XP_003385086  430 CLSRFSYFQTNSVIAIFTKSISTLTGIAERRLLsHYPeVd------------aERKILAIYVFLCYFLREAGYIERAIAT 497  Amphimedon qu...
A0DU55        221 KLK-TEIFSATMLRIEANKHIANLQKLINETTRaQLVqLf-------------KRIYIELIQQIAFYESEMGFKERSVGI 286  Paramecium te...
EFA79562      458 NMSNFAVFTIGDTRQHFARLVQLLLAKRRTLKPrDHGfMasv--------gkvEEALLGFVGQWARFERHAGYTERAIGM 529  Heterostelium...
XP_003292652  466 CLSNFNNFTVNKMKETITQVIRKLLIKRRSFKVkEKNfMerv--------qvvEESILQFLSQLTRFLHQAGYSERVVGI 537  Dictyostelium...
Q54QP0        465 CLSNFNDFKIEKIKETIITIIRKMLVKRRSFKVkDYNfMeni--------snlEESILQFISQLSKLLNQAGFSERVIGI 536  Dictyostelium...
ERN11072     1614 CLGDFSRFKVSYLRKIYSHAVRALSSAFGRLCGqIDDmAktgsva--seltqlETGLVDIFVSLCRFEWQTGHQELATGL 1691 Amborella tri...
XP_003549192  405 VQRNFSRFKVSEVRKMYAHAIEALSASCSKHSRqVLQaAnpsspd--pvfvqlELGLVDIFLSLCRFEWQTGYRELATAL 482  soybean
Q9LSH4        381 VQGEFSRFKVSEVRRLYSYAIQALSSACSKRHRqVDTtSeplds----aaiqqELVLVDMLVSLCRFEWQAGYQELATAL 456  thale cress
KJE91902      796 YQALVELCWFAPTTMdpvltpsTKTTLKgllaF---FEPFWDS-SVPRFSDAGAAGWRAWHTQHVvn--qTAAqhdipvs 869  Capsaspora ow...
XP_004997320  543 LQALVEFNLFMPSRVr------SPREATg---F---LESFWES-NAPRFGDPGARGVGHFIDQKRartdvpslqq----- 604  Salpingoeca r...
XP_003385086  498 FQALIEFSLLCPIDEy------PADGFYpriaRrkgLESFWET-DEPRFGEEGAVGWTGWEHREEveptpLGLfpsdkyd 570  Amphimedon qu...
A0DU55        287 LQALCEMNLFAPKHL---------QRTYdleeKvkeFRNYWDM-NV-RTGEQNEYGWIDTP------------------- 336  Paramecium te...
EFA79562      530 YQSLIEFNCFLPVHLeranqqqQ-Ilr--------sFKLFWEA-ELPRVGESEAQGW-------Lnnrvdnetqltieem 592  Heterostelium...
XP_003292652  538 YQALIELNCFEPIALsne--pqSVLlk--------eFKEFWVSnNYAKIGESNSIGWSNAYNQILndkinstgkndggle 607  Dictyostelium...
Q54QP0        537 YQSLIEFNCFEPIQLsne--tqATLlk--------eFKSYWSSlDYPKIGNPNSIGWSKSFTILLnnsinNNNnknnnnn 606  Dictyostelium...
ERN11072     1692 FQALIEYNLFCPSLL---------LTENskqrL---FEHFWNG-DGARVGEDGALGWSAWLETEEenrqkAIAtevsfqd 1758 Amborella tri...
XP_003549192  483 FQAEIEFSLFCPPLL---------LTEQskhrL---FEHFWNS-GGARVGEEGALGWSTWLEKEEetrqrVMNeelsren 549  soybean
Q9LSH4        457 LQAEVEFSIFSPSLL---------LTEQsklrL---FEHFWSS-NGARVGEEGAFGWLLWLEKEEenrqkILKeessddn 523  thale cress
KJE91902      870 gmrasspt----------------------------------------------------------ppslsqedaefsvy 891  Capsaspora ow...
XP_004997320  605 -----------------------------------------------------------------------hhppttppe 613  Salpingoeca r...
XP_003385086  571 kllkespkd-------------------------------------------------------kegeteeeeedidikf 595  Amphimedon qu...
A0DU55            --------------------------------------------------------------------------------      Paramecium te...
EFA79562      593 eellreqeleeqqtiqrqqqi------------------------dqqdifnlkvenkpddvdvddldneqkqqqveeve 648  Heterostelium...
XP_003292652  608 dldnlsieeiekllkeqedlekqse----------------lnqnnnenlftinesnfneqndddinqddqdinktkesy 671  Dictyostelium...
Q54QP0        607 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnmdldnldnlsieeiekllkeqedqenqdnenifnithkskdlnedd 686  Dictyostelium...
ERN11072     1759 tekggwtgwseplsrvsensgmnqyteenna-----------idegnveedmpenideedemaslmeklgmginadadve 1827 Amborella tri...
XP_003549192  550 egggwtgwsepwskdnegianvehetmndvv------------mediqdeeeytevepevdtedllkmlgidmndgdgge 617  soybean
Q9LSH4        524 evggwtgwteqvsgrngddiasantgevdvd------------rkgldeemedenskpeddteamlkllgidvntaasde 591  thale cress
KJE91902      892 AETLARQpverplaasqsadgrtvDLWLNAELKRDSHHWRPLRmppqdadtlgnlEAAATLDelieRDPEQVVLFEDISA 971  Capsaspora ow...
XP_004997320  614 LKGVTTW-----------------ERWLEVETFREQQHWLPWRpn---------eEEGEEEEd--cEDPDRCVIFDDVAG 665  Salpingoeca r...
XP_003385086  596 VSGQPLN-----------------KAWLKIESYRDEENSLPGRls--------apVNSKMNSd--sEDPEHITLFDDLIQ 648  Amphimedon qu...
A0DU55        337 -ELKDDFigyfdlsqqiqeqedqiQQFLSFQQL---KRWRPAN--------------QRFDIewieQNVDAAVIYEDIEP 398  Paramecium te...
EFA79562      649 EEGESNDkmevevevkernekkewLEWSEKEMESELNRWIPSRv----------lEIPDEES----HDTDRLVLFDDIKD 714  Heterostelium...
XP_003292652  672 Knkntpes----------ihenkfINWGKNEIKKDTSKWLPLNidka----tlndEMGEEND----QDTDRVVLFNDVFD 733  Dictyostelium...
Q54QP0        687 Dnennnnnqeeqedndsnsndndnnnnkfntwgkkeieldelkwkpldinnnlevnkevnendtervvlfndfyellfrf 766  Dictyostelium...
ERN11072     1828 IKDTTVW-----------------MKWSEEETARCSGQWMPVRek------------sDNNDe---AQLSREVLFEDVSD 1875 Amborella tri...
XP_003549192  618 VNDTLTW-----------------IKWSKEESSRDCDQWMPVRgksgt--tspanEADKTDEd---EQLLRVVLYEDVNE 675  soybean
Q9LSH4        592 VKDTSTW-----------------VKWFEEEVsrdhsqwmptrkagefssvegmgegedeeqlssvvlyedingylfslr 654  thale cress
KJE91902      972 FLFRITaPEIKEALLWRFVEFLG 994  Capsaspora owczarzaki ATCC 30864
XP_004997320  666 HLFRLStPELKTDLVLGFVDFLG 688  Salpingoeca rosetta
XP_003385086  649 IMFMMPdPELHYLLLLEFVRFLG 671  Amphimedon queenslandica
A0DU55        399 YLYIFNdQESKLNLVSILLQQIG 421  Paramecium tetraurelia
EFA79562      715 ILFRMVkDEDKLYLVYQFLEFLG 737  Heterostelium album PN500
XP_003292652  734 LLFKFVrDEIKIELIFQFLEFLG 756  Dictyostelium purpureum
Q54QP0        767 vkeenklelvfqfleflgvpisl 789  Dictyostelium discoideum
ERN11072     1876 YLFSLSsEESRYYLLSHFIDFFG 1898 Amborella trichopoda
XP_003549192  676 YLFSLStTEARLSLLSQFIDFYG 698  soybean
Q9LSH4        655 skearlslvyqfidffgahispw 677  thale cress
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