Conserved Protein Domain Family
7tm_7

?
pfam08395: 7tm_7 
7tm Chemosensory receptor
This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family.
Statistics
?
PSSM-Id: 400619
View PSSM: pfam08395
Aligned: 76 rows
Threshold Bit Score: 85.5321
Threshold Setting Gi: 47115835
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q8IPU5  37 LGILYSLTRVFG--LMATanw--sprGIKRVRQSLYL-RIHGCVMLIFVGCFSPFAFWCIF----QRMAFLRQNRILLMI 107 fruit fly
Q9W1N6   7 ENLLLTINRFLG--VYPS-----------GRVGVLRW-LHTLWSLFLLMYIWTGSIVKCLE-------FTVEIPTIEKLL 65  fruit fly
Q7PF39  19 ISPTVRLSQCLS--LAPYplsv-fqrNCSTRSVRIRIiICFRYAFATCVTVAVVASQFTMFyyfpHIMYQPKVPIFIVIL 95  Anopheles gambiae str...
Q7PF38  19 FNLLLNIAQLAG--FLPFpayv-lrqDVERLHFRTLVlTCLNLTFAVLIFLTSFVCYLAMYiyypDLMYKENLPAVLQIM 95  Anopheles gambiae str...
Q7PF36  19 FRPLLNVAQCFG--FLPYpfdfqrqaEVKNIVLQKML-TILNRTFGLAMIGTVLTCCVSLYvcypSYMYEEDYPPVLNIA 95  Anopheles gambiae str...
Q7PF19  20 LYRLLTVGQVFG--LVAWdlq---plEPDRPTTKLHW-FRKLIRATNQGYCFMIIVAIGTAtvlhHSSNTANAFFAIRTL 93  Anopheles gambiae str...
Q9VYZ2  11 LRFWMGLILVLGfsSHYY--------NPTRRRLVYSR-ILQTYDWLLMVINLGAFYLYYRYamtyFLEGMFRRQGFVNQV 81  fruit fly
Q9VEU0  10 LCLLLKYWQILA--LAPFr------tSEPMVARCQRW-MTLIAVFRWLLLTSMAPFVLWKsa-amYEATNVRHSMVFKTI 79  fruit fly
Q8IMQ6  41 VFLNILYGVYLG--------------RFSFRRKKFVFsKGLTIYSLFVATFFALFYIWNIY------NEISTGQINLRDT 100 fruit fly
Q8IMZ5  17 TIILIGFMTVFG--LLANr-------YRAGRRERFRFsKANLAFASLWAIAFSLVYGRQIY------KEYQEGQINLKDA 81  fruit fly
Q8IPU5 108 GFNRYVLLLVCAFMTLWIHCFKQAEIIGCLNRLlKCRRRLRRLMHTRKl---kDSMDCLATKGHLLEVVVLLSSYLlsma 184 fruit fly
Q9W1N6  66 YLMEFPGNMATIAILVYYAVLNRPLAHGAELQIeRIITGLKGKAKRLVykrhgQRTLHLMATTLVFHGLCVLVDVV---- 141 fruit fly
Q7PF39  96 YYIVSILQTLTTGNMMIGCEQRRAEYEGYFEEVlHLMKETAHQPDCKTt----IWYRHVTKVLLALYCIASLTVPI---- 167 Anopheles gambiae str...
Q7PF38  96 YHVENWLRVVMVLIALVGPRLSGRYFRETIDTLvHIMKLFDRATKIESiltaiSVITNRLLLLYGLHALIITVTVW---- 171 Anopheles gambiae str...
Q7PF36  96 YHLENWLKIVTVLVAVLRSQTSTAYFRETVNSLvQIMVQYDQGWRIERklasvATVSKRLSVVFLLDDFTIATGLY---- 171 Anopheles gambiae str...
Q7PF19  94 YLTENVIVNVIVLFAMLECQQSRPFYASILKELfELGKNLHDCDASINfphveAITDRLLVCAVLYFSTSSLVDWW---- 169 Anopheles gambiae str...
Q9VYZ2  82 STCNVFQQLLMAVTGTWLHFLFERHVCQTYNELsRILKHDLKLKEHSRf----YCLAFLAKVYNFFHNFNFALSAImh-- 155 fruit fly
Q9VEU0  80 ALATMTGDVCISLALLGNHLWNRRELANLVNDLaRLHRRRRL-----------SWWSTLFLWLKLLLSLYDLLCSVpf-- 146 fruit fly
Q8IMQ6 101 IGIYCYMNVCVCLFNYVTQWEKTLQIIRFQNSVpLFKVLDSLDISAMIv---wRAFIYGLLKIVFCPLITYITLILy--- 174 fruit fly
Q8IMZ5  82 TTLYSYMNITVAVINYVSQMIISDHVAKVLSKVpFFDTLKEFRLDSRSl----YISIVLALVKTVAFPLTIEVAFI---- 153 fruit fly
Q8IPU5 185 qpiQILKDDPEVRRNFMYACSLVFVSvcqaILQLSLGMYTMAILFLGHLVRHSNLLLAKILADAEHIFEssqkagfwpnr 264 fruit fly
Q9W1N6 142 -----NYDFEFWTTWSSNSVYNLPGL----MMSLGVLQYAQPVHFLWLVMDQMRMCLKELKLLQRPPQGstkldacyesa 212 fruit fly
Q7PF39 168 -------VMTTILWDIATIPYVMAQTvpfvVSSLILNQYFCVFVHLTSILRKMNERLARFLNMLPGSATeppvqlrgkpl 240 Anopheles gambiae str...
Q7PF38 172 ------ISTEHPVSTLLNVSYLAPYV----TIAVYILLYRALLASIAGIVGCLNDNLREITIQDRIDPRrtygkhttisy 241 Anopheles gambiae str...
Q7PF36 172 ------FIVEGAPATLINLCYIPPFI----AIVINVLHYYALFGTISGIMSCSNDTLYGITVEGKKDRHrscsgrksn-- 239 Anopheles gambiae str...
Q7PF19 170 -----ADYDPSCTFLCHSVLYILPNV----INVLALYQYAALQLIVAACYRSVNSVLARYHDHQARPKvrdc-------- 232 Anopheles gambiae str...
Q9VYZ2 156 --wGLRPFNVWDLLANLYFVYNSLAR------DAILVAYVLLLLNLSEALRLNGQqehd--------------------- 206 fruit fly
Q9VEU0 147 -lkGAGGRLPWSQLVAYGVQLYFQHV-----ASVYGNGIFGGILLMLECYNQLEreep---------------------- 198 fruit fly
Q8IMQ6 175 ---HRRSISESQWTSVTTTKTMLPLI----VSNQINNCFFGGLVLANLIFAAVNRKLHGIVKEANMLQSpvqmnlhkpyy 247 fruit fly
Q8IMZ5 154 ---LQQRRQHPEMSLIWTLYRLFPLI----ISNFLNNCYFGAMVVVKEILYALNRRLEAQLQEVNLLQRkdqlklytkyy 226 fruit fly
Q8IPU5 265 qelykgqqkwlalelwrllHvhHQLLKLHRSICSLCAVQAVCFLGFVPLECTIHLFFTYFMKYskFILRKYGR------- 337 fruit fly
Q9W1N6 213 fa-----vlvdagggsalmI--EEMRYTCNLIEQVHSQFLLRFGLYLVLNLLNSLVSICVELYliFNFFETPL------- 278 fruit fly
Q7PF39 241 iynv-lgeslkmessrldqL--EQLRLLHVRTVQTAGSLSEKFGIVIILIVIAAFASVNIELL--EFYQSIKLg------ 309 Anopheles gambiae str...
Q7PF38 242 imlq-egkervtspldvatI--VRLSTMHMALMRLARAANKHFGVLMLIIVLSTFIQINMLLL--ELYHNISHp------ 310 Anopheles gambiae str...
Q7PF36 240 -----------tkendittI--DKLVRLHTALLHLTWKTNAHYGVLLLIIMLYSFIQISVILA--ELYFDNY-------- 296 Anopheles gambiae str...
Q7PF19 233 ------------------aelvETLRRTHLKLGDLTGRVVGRFGPLIVCTVLSSFVVLNLELF--NVYKATGRgskrvws 292 Anopheles gambiae str...
Q9VYZ2 207 ---------------tysdL--MKQLRRRERLLRIGRRVHRMFAWLVAIALIYLVFFNTATIYlgYTMFIQKHdal--gl 267 fruit fly
Q9VEU0 199 ------------------tnlaRLLQKEYSWL-RLIQRFVKLFQLGIFLLVLGSFVNIMVNIYafMSYYVSL-------- 251 fruit fly
Q8IMQ6 248 r----------mrrfceladllDELARKYGFTASRSKNYLRFTDWSMVLSMLMNLLGITMGCY--NQYLAIADhyi-nee 314 fruit fly
Q8IMZ5 227 r----------mqrfcaladelDQLAYRYRLIYVHSGKYLTPMSLSMILSLICHLLGITVGFY--SLYYAIADtli-mgk 293 fruit fly
Q8IPU5 338 SFPLNYFAIAFLVGLFTNLLLViLPTYYSERRFNctreIIKGGGLAF-----PSRITVKQLRHT--MHFYGLYLKnVEHV 410 fruit fly
Q9W1N6 279 WEESVLLVYRLLWLAMHGGRIW-FILSVNEQILE----QKCNLCQLLne----lEVCSSRLQRT--INRFLLQLQrSIDQ 347 fruit fly
Q7PF39 310 TLTPTTIFMKFLYAASKFSFYI-LIAYPNRLIQQ----ENQKALFMLyr--iKRISCSVELNEA--IEHFISQIS-NLHD 379 Anopheles gambiae str...
Q7PF38 311 VMPEYCLWVLFLHAIVHFTFFF-VIATSNHAIQQ----ENERTMLLLhe---fKCSWSSEQNMT--IEHFISQIS-NLHD 379 Anopheles gambiae str...
Q7PF36 297 DLPLVFVGICLTHAAVYFMFFL-IIAHANHAIIM----ENERTLLLLld---iNCIWNSELNGM--VDYYFMQVS-NLQD 365 Anopheles gambiae str...
Q7PF19 293 ASEGFRLVHTLLWIGLHGAKIL-LILYPGHRARV----ECERTGPTLyeiasRYEAAG-RSNSA--LMKFAGQLL-LLHG 363 Anopheles gambiae str...
Q9VYZ2 268 RGRGLKMLLTVVSFLVILWDVV-LLQVICEKLLA----EENKICDCP-----EDVASSRTTYRQweMSALRRAIT-RSSP 336 fruit fly
Q9VEU0 252 HGVPLTISNNCLVLAIQLYAVI-LAAHLCQVRSA----KLRKKCLQL-----EYVPEGLTQEQAmaSTPFPVLTP-TGNV 320 fruit fly
Q8IMQ6 315 PFDLFLAIVLVVFLAVPFLELV-MVARISNQTLT------RRTGELLqr--fDLQHADARFKQV--VNAFWLQVV-TINY 382 fruit fly
Q8IMZ5 294 PYDGLGSLINLVFLSISLAEIT-LLTHLCNHLLV----ATRRSAVILqe--mNLQHADSRYRQA--VHGFTLLVT-VTKY 363 fruit fly
Q8IPU5 411 f--AVSACGLFKLNNAILFCIVGAILEYLMILIQFDKVL 447 fruit fly
Q9W1N6 348 ---PLEACGIVTLDTRSLGGFIGVLMAIVIFLIQIGLGN 383 fruit fly
Q7PF39 380 ---VHQACGMLNLDMKLISNAVAAITSIMVVLIQFSDTG 415 Anopheles gambiae str. PEST
Q7PF38 380 ---VHQACGMLNLDMKLISNAVAAITSIMVVLIQFSDTG 415 Anopheles gambiae str. PEST
Q7PF36 366 ---THQACGMIKLDMQLVPNVIAVITSILFILMQFSDAD 401 Anopheles gambiae str. PEST
Q7PF19 364 krhHCKACGLITLDLTLISKVVAGLTTYLMILIQFDSAF 402 Anopheles gambiae str. PEST
Q9VYZ2 337 ---ENNVLGMFRMDMRCAFALISCSLSYGIIIIQIGYIP 372 fruit fly
Q9VEU0 321 ---KFRILGVFILDNSFWLFLVSYAMNFIVVILQTSFEH 356 fruit fly
Q8IMQ6 383 ---KLMPLGLLELNTSLVNKVFSSAIGSLLILIQSDLTL 418 fruit fly
Q8IMZ5 364 ---QIKPLGLYELDMRLISNVFSAVASFLLILVQADLSQ 399 fruit fly
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap