Conserved Protein Domain Family
Ly49

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pfam08391: Ly49 
Ly49-like protein, N-terminal region
The sequences making up this family are annotated as, or are similar to, Ly49 receptors. These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function. They are members of the C-type lectin receptor superfamily, and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (pfam00059).
Statistics
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PSSM-Id: 400616
View PSSM: pfam08391
Aligned: 22 rows
Threshold Bit Score: 130.168
Threshold Setting Gi: 50950223
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q75XR1        41 SVPWHLLVVTLGILCLLLLVTVIVLGTNIFKRIQEKPQQEEIPqNFSQKYNIIQKDNYLKEQLLTNKTLEYDILKNenlq 120 horse
XP_004052762  41 SVPWRLIAVTLGILCLLLLMIVTVLVTNIFQCIQEKHQQQEILrNCSEKY-IMQNDNYLKEQILTNKTLKYDVLKNdsfq 119 western lowland...
XP_008509527  41 SVPWHPFVVTLGILCLLLLVTVTVLGTMIFQCFKEKHQQEEILrKLIPQYDSIRNNNYSKEQLLINKTLECDILKNktlh 120 Przewalski's horse
XP_008509527  41 SVPWHPFVVTLGILCLLLLVTVTVLGTMIFQCFKEKHQQEEILrKLIPQYDSIRNNNYSKEQLLINKTLECDILKNktlh 120 Przewalski's horse
NP_001075393  41 SVPWLPFVVTLGILCLLLLVTATVLGTMLFQCIQEKYQQEEILrNLSQMYDIIKKDNYLKERLLINKTLECDVLRNetlh 120 horse
XP_020946832  41 SVLWHRIAVILGILCFLLLVTVIVLGTKTFQYIQEKHQQEEILrNLTQKYHLMQNENYLNEQLLTNKTLEYSILY----- 115 pig
Q8SPQ6        41 SVPWHGIAVTLGILCLLLLMTITVLGIKISQYILEKHQQEEALwNLSQKYDVVQNDNYLNKQLLTKKTSECDRLNEtlqq 120 cattle
Q5MPW8        48 SVTWKPIVIVLGILCSLLLVTVAVLLTHIFQSRQEKHEHEQRLnNLDQLYHVMKNDSSLMEERLRNKSLEFETCKN---- 123 Norway rat
Q60660        40 SVPWKFIVIVLGILCFLLLLTVAVLVIHIFRDGQEKHEQEKTLnNLRQEYQVMKNDSSLMEEMLRNKSSECKALND---- 115 house mouse
Q5MPP5        40 YVPWHLIVIALGILCTLLLVTVAVLVTNIFQYSQENHELQETL-N-QHNCSAMQNDIDLKEEMLRKKAIECSPGND---- 113 Norway rat
Q75XR1       121 lkkDLESLSKAKMSCHRKQGIFSKSLQNTGKLNEdRWSCCGVNCYYF 167 horse
XP_004052762 120 qkkELDSHLIQKNRCHRENEIVFKVLQNTGKFSEdHWSCCGVNCYYF 166 western lowland gorilla
XP_008509527 121 qkkELDSLFMEKMRCHIKQEIFSKSLQSTGKFNEdHWSCCGVNCYYF 167 Przewalski's horse
XP_008509527 121 qkkELDSLFMEKMRCHIKQEIFSKSLQSTGKFNEdHWSCCGVNCYYF 167 Przewalski's horse
NP_001075393 121 qkkELDSLFVEKMRCHIKQEIFSKSLQDTGKLNEgRWSCCGVNCYYF 167 horse
XP_020946832 116 ---------NQRKGCCRKMDVFSKPLQNTGHLNEgHLSCWRGNFYYF 153 pig
Q8SPQ6       121 ikgLSDLVFTEKKGCYHKKKS-SESLPNTGELKEvSWWCWGVNCYYF 166 cattle
Q5MPW8       124 ---TLDNLNREQNRCYRESKIDLKCFKYKGKQVEgHWFCCGMKCYYF 167 Norway rat
Q60660       116 ---SLHYLNREQNRCLRKTKIVLDCSQNKGKQVEgYWFCCGMKCYYF 159 house mouse
Q5MPP5       114 ---LLELLNREQNRWYSKTKTVINSLQHTSNEIEtHWFCYGIKCYYF 157 Norway rat
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