3ICQ,4C0P,2X19,5YU6,4HB0,5DIS


Conserved Protein Domain Family
Xpo1

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pfam08389: Xpo1 
Click on image for an interactive view with Cn3D
Exportin 1-like protein
The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.
Statistics
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PSSM-Id: 400614
View PSSM: pfam08389
Aligned: 54 rows
Threshold Bit Score: 56.8593
Threshold Setting Gi: 332190829
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ICQ_U  103 PAYISNAVQHLLTLLFLQLYPSNWNDFFASLQgviAASSQ----------SEFSNFYLKVLLSIGDEIADslVLKTDVQI 172  fission yeast
Q5SPJ8   98 KPFIRNKAAQVFALTFVMEYLTLWPKFFFDVL---ALVGLn---------PNGVDIYLRTLMAIDAEVVDrdILHSPEET 165  zebrafish
O43592   98 KTFIRNKAAQVFALLFVTEYLTKWPKFFFDIL---SVVDLn---------PRGVDLYLRILMAIDSELVDrdVVHTSEEA 165  human
Q7PC79  106 PPFVKNKLAQVLATLIYYEYPLIWSSVFLDFMl--HLCKG----------AVVIDMFCRVLNALDDELISldYPRTPEEI 173  thale cress
Q8H3A7  103 PPFLRNKLAQLLALLVRFEYPHVYPSYFLDLI---PPSPPl---------PGPTDMFARVLVSLDDDLLSqdYPRNAEEA 170  Japanese rice
Q5CYM5  121 QSYLKNKISELYVTMIYADYPENWPSAFLDIV---SLVTAh---------DWMPDMFIRILCTFDKMIVSniGLQSAEDI 188  Cryptosporidium parvum
Q8IEF5   94 DSCVLNKIIQLYLYLIEFLYPHNMNDAFKYLI---NLIMLnndi---nikTIHINFFLKLMNMFDSEYID--NVCSNKSI 165  Plasmodium falcipar...
Q7RWV9  103 PANVQNKLTQTLTYLFVALYGEGWETFFDDFL---ALTSSqnga--srdnLSGVMLYLRILSSVHDEIADlmISRQGNES 177  Neurospora crassa O...
Q5ASE3  102 PPNIQNKIAQTITFLFSALYGNGWESFFDDLL---SLTHKspsst-trdnPLGIIFYLRVINSIHDEIGDvlVSRSRAEQ 177  Aspergillus nidulan...
Q5A0E2  100 PTHLRNKFAQILAKQFCQVYINIYPNFIKDLL---ELINVseatstnpnnLLAIDYYTRVLIGIHSEIGDkyITRSQEIH 176  Candida albicans SC...
3ICQ_U  173 QKDNLVKDAIRANd-MSDIVSFVYEMMLAYSNAKn----YGTVGLCLQVYAQWVSWININLIVNEPCMNLLYSFL----Q 243  fission yeast
Q5SPJ8  166 RRNTLIKDGMREQc-IPALVESWFQILQTYQHTH-----SELTCQCLEVVGAFVSWIDLNLIANDRFVNLLLSHM----S 235  zebrafish
O43592  166 RRNTLIKDTMREQc-IPNLVESWYQILQNYQFTN-----SEVTCQCLEVVGAYVSWIDLSLIANDRFINMLLGHM----S 235  human
Q7PC79  174 SVAARVKDAMRQQc-VPQIARAWYDIVSMYKNSD-----PDLSATVLDCMRRFVSWIDIGLVANDAFVPLLFELIlsdgL 247  thale cress
Q8H3A7  171 SDAGRVKDAMRAQc-VPQIARHWHEAAVSLRAAD-----PAVAAVALDAARRCISWIDVSLVANDVFVPLLFDIAlspgS 244  Japanese rice
Q5CYM5  189 SIRRKIKDIMRVNgdLNHIVQAWIFVVSKHKSQSltkdrIQLLSSSMKMMESFIDWIDISYAVNNEVLSIILSFL----N 264  Cryptosporidium parvum
Q8IEF5  166 QTTTNIKEAIKENd-LPIIIECFYYIMNMNI--------PESTSLSIFTLSKYVPWIDINYVVNDKILTYIYQTL----N 232  Plasmodium falcipar...
Q7RWV9  178 KRNNDLKDLIRERh-MQKIAMSWQDILAQWTNKH-----DGVVELTLKVIGKWVSWIDISLVVSQDMQNLILPLV----G 247  Neurospora crassa O...
Q5ASE3  178 ERANALKDLIRVRd-MQKIASSWQEILSQWMDGD-----DLIVEMSLKAVGSWVSWIDIGLVVNQTMLDLLFQQL----G 247  Aspergillus nidulan...
Q5A0E2  177 NRNNLLKDAIRTQd-MQQMVTSWIQIL---TNPSfa-hsEEILNNTLKIVGQYVSWMEISLFISPEFINTVFSFL----Q 247  Candida albicans SC...
3ICQ_U  244 IEEL----------RCAACETM 255  fission yeast
Q5SPJ8  236 MEEL----------REAACDCL 247  zebrafish
O43592  236 IEVL----------REEACDCL 247  human
Q7PC79  248 SEQV----------RGAAAGCV 259  thale cress
Q8H3A7  245 VAPL----------AAAAVGCL 256  Japanese rice
Q5CYM5  265 PIDSp--------vVVETLNFL 278  Cryptosporidium parvum
Q8IEF5  233 TTNSi---------TEASYSFL 245  Plasmodium falciparum 3D7
Q7RWV9  248 RVNNtsnn--idtvRDTAIDTL 267  Neurospora crassa OR74A
Q5ASE3  248 RAQKaelregedkvRDAAVDVF 269  Aspergillus nidulans FGSC A4
Q5A0E2  248 NSKL----------RNTTCETL 259  Candida albicans SC5314
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