6F1T


Conserved Protein Domain Family
DHC_N1

?
pfam08385: DHC_N1 
Dynein heavy chain, N-terminal region 1
Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Statistics
?
PSSM-Id: 400611
View PSSM: pfam08385
Aligned: 212 rows
Threshold Bit Score: 262.177
Threshold Setting Gi: 75002745
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6F1T_EE       242 LNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLTLDILKHGKR-------FHATV 314 
A0D7F8        232 VQSISQTVTRWISDINQISNTKLELTNASIVDEINYWMSMERSLFFIENQLKQPEVDFTIEVLTQAKK------------ 299  Paramecium te...
XP_004039886   77 INNLCQCVTKWTKDIQAVIKINYDVSSGTTLQEINYWLSYERSLNLINQQINLPEVQLTIDILKQKKK------------ 144  Ichthyophthir...
ESS29321      293 LIALQNHVNRWIKDIQKVCRMQRDASTGSAAEEVNFWEGMERAILRVEEQLKTPEAELTLQVLKQTRK------------ 360  Toxoplasma go...
Q7RPJ1        305 LNQLQKDVTKWVEEIQKITRLNGDFKSGSALAEINFWIGYENALLELENRLKSPEVILTLQILKNAKR------------ 372  Plasmodium yo...
EEA07374      295 LSGLQMSLTQWIRDIQSLARFQRDIGL-SVTSEVKFWSSYERSLQQIMQQIQSVEVEWSLAVLRQTKK------------ 361  Cryptosporidi...
Q5CSZ3        289 LSSLQVSITQWIREIQSLARFQRDIGL-SVTSEVKFWSSYERSLQQILKQVQSPEVEWSLSVLRQSKK------------ 355  Cryptosporidi...
XP_004993240  227 LDALSKTLARWTREIQQVTKLERDPSTGSAMQEVSFWRNLGTALQAIKKQRESPAVTLTIGILQHGRR------------ 294  Salpingoeca r...
EGD73488      220 VKSLERVVLRWIKDIQQVTRLERDLSTGSARQEIRFWLSMERALSQLKVRLAEDDVTLTLAVLREAKR------------ 287  Salpingoeca r...
XP_022522624 3513 KQSLLEDAEACRRKMSNAMALID-----GLGGEKIRWTESSTEFQRQIKHLPGD-VLLATGFLSYAGPfnqeyrnLLLQQ 3586 Mexican tetra
6F1T_EE       315 SFDT-----DTGLKQALETVNDYNPLMKDFPLNDLLSAtELDKIRQALVAIFTHLRKI-RNTKYp-IQRALRLVEAISRD 387 
A0D7F8        300 MNITaq-fkEIALKQSLQKCQSCNQFMKEFPINNLLIatNLVEIKDAMIQIFQHMKKLsNIQETytIPRSLQLAESFSRE 378  Paramecium te...
XP_004039886  145 FTITmtfeeDLKFKEQLQNCQKCNAFMKEFPLNDLLSagTLAEVKNSITFIYNHMKNIrSIS-Sy-TTRAFDLLETLSRD 222  Ichthyophthir...
ESS29321      361 VFATmtfeqDAGLKQASDMVASVNILIRDFPVNDLLGatSVEQLTQAVRTVFMHL-RKlKNAAQypLSRAYHLVEALSRD 439  Toxoplasma go...
Q7RPJ1        373 YFATisfdsDIQLKQSKEYVLNVNILMKDFPIDDLLGaqTVQQTMQAIRNIFNHL-KKlKNTTKypLSKSYNFVEALSRD 451  Plasmodium yo...
EEA07374      362 FLAAislevDTGLKQTLERVQSVNSLIHDLPINDLLVasTVDEIISAVHLFFQHI-RKiKAVAAypISRVFQLVEVYSAD 440  Cryptosporidi...
Q5CSZ3        356 FLAAislevDTGLKQSIEKVQNINTLIHDIPINDLLVatSIDEITSAVTLFFQQL-RKiKGAASypISRTFQLVEVYSND 434  Cryptosporidi...
XP_004993240  295 FHATmsfdqDSGLDAKIKLVNDYNELMHGFPAKDLLAasDTEQLRQALVTIFSHL-KRiRKT-KypVKRCQNLILAISRD 372  Salpingoeca r...
EGD73488      288 LTILksfetDTNLS-MYDTVLDYNTLMKDFPINAILIatDIKKLVEAMLEVFQHM-KKvKHT-RypRERFIELIKAISRD 364  Salpingoeca r...
XP_022522624 3587 WKKE-----MSGNHIPYSQSFNLITMLVDN--ATLGEW-NLQGLPNDDLSIQNGI--IvTSASRy------PLLI----D 3646 Mexican tetra
6F1T_EE       388 LSSQLLKVLGtrK------LMh--vAYEEFEKVMVACFEVFQTWDDEY---E-KlqvllrdiVKrkreenL-KMVWRI-- 452 
A0D7F8        379 LTNEMIKYFK--Gf----qILhikyV--DFKGLIIKTQEIFSQWDEEYkifKqS--------IV------------KKs- 429  Paramecium te...
XP_004039886  223 LNNQMTKILGny------kLMtmnyD--HFIDLMKECDEIFKRWEKEYaafKqS--------IQy--------------- 271  Ichthyophthir...
ESS29321      440 LSQRLVAVLS--Qq----hLLllgfE--EFEHATGGCSELFRTWEEEVrqfKeM--------VR------------DQa- 490  Toxoplasma go...
Q7RPJ1        452 LGNTMKKILS--Nq----sLLsmdyQ--IFDVLISGCMEVFQLWNEEIrvfKdM--------VR------------ELi- 502  Plasmodium yo...
EEA07374      441 MTRQLYKVLQ--NtpskvsLMnleyP--LFEHLVNGCNELAQTWEDEWrllKeI--------IR------------DLi- 495  Cryptosporidi...
Q5CSZ3        435 MTKQMYKVLQ--Nnpt-tsLMllefP--VFEHLVNGCNELGQVWEDEWrelKdV--------IR------------DLi- 488  Cryptosporidi...
XP_004993240  373 MAAQLTAILS--Nl----eLMhmsyA--DFDRTIHGCSRLFKTWEEEVerfRtQ--------LR------------MQl- 423  Salpingoeca r...
EGD73488      365 VNSQLLKILS--Kk----kLMhmpiP--EFENLYNQCNQLFREWNDKsd-fRtI--------IQ------------ELrs 415  Salpingoeca r...
XP_022522624 3647 PQGQGKTWIK----------------NREANHDLQVTSLNHKYFRAHIe----D--------CL------SlGKPLLI-- 3690 Mexican tetra
6F1T_EE       453 -NPaH---RKLQ--------------ARLDQMRKFRRQHEQLravivrvlrpqvtavaqqnqgevpepQdMKVAEVLFD- 513 
A0D7F8        430 -VHqK---DQYGqfeh------iklqKQIQHIQRLREMHENL--------------------------K-EVIEQIIQNd 472  Paramecium te...
XP_004039886  272 -KTqTsryflh----------vdflqKRLNLIQEIRKLHFTL--------------------------N-EVIQNIINKe 313  Ichthyophthir...
ESS29321      491 -KKrGl--SERPpaklvc--ehlviqERIGELRQFRRQHHRL--------------------------K-EVISRVLSEn 538  Toxoplasma go...
Q7RPJ1        503 -KKrSf--NERApakmvf--ehvilqERLDDIRKFRKQHQKF--------------------------K-TVITKVFGNd 550  Plasmodium yo...
EEA07374      496 -KKrGl-sERAHpkldfn---hipliQRLNDIVAFRKQHQKL--------------------------K-DTLVELLTSr 543  Cryptosporidi...
Q5CSZ3        489 -KKrGl-sERAHpkmdfa---hvpliQRLNDIVIFRKQHQKL--------------------------K-DTLLELLSIq 536  Cryptosporidi...
XP_004993240  424 -RQnP---DPNMrtlkilhpehrplqERIEELRKFRASHEQL--------------------------R-NVIERVLRAp 472  Salpingoeca r...
EGD73488      416 tQRgG------RatarrvvpehkalqERLALVHDFRLRHDDL--------------------------K-QRISVVLKQr 462  Salpingoeca r...
XP_022522624 3691 -EDvGeelDPVL--------------DNILE-KNFIRSGSTY--------------------------K---VKVGDKE- 3724 Mexican tetra
6F1T_EE       514 --------------------------------AADANaiEevNLAYENVKevDGLDVSKEGteaWEAAMKRYDERIDRVE 561 
A0D7F8        473 qeeqke-------------------nvqqfatLQEIQ--Q----AYDIFKnvEVFDLSRDGedqFFRALKQYEIAIESVE 527  Paramecium te...
XP_004039886  314 ksgdrf-------------------gdasflsTKEIN--E----AYSIFDdiDILNSTDEGelsVKQAKNQYEQRIDQIE 368  Ichthyophthir...
ESS29321      539 agg-------------------------dltaQKEVA--S----AYELLQsvDVLDLSRAGqeaWEAARKAYDDRIDRVE 587  Toxoplasma go...
Q7RPJ1        551 knv-------------------------ginlHKDIN--A----AYNVLLslDALDLSKSGndlWEKTKLSYESKMNKVE 599  Plasmodium yo...
EEA07374      544 sgdtrnettas---------trggmdmlqtlaKKDLE--Q----AYACVAniNILDLSSIGletWEAGKQAYNNKMDASE 608  Cryptosporidi...
Q5CSZ3        537 tsassneqtdqnplsalgieqnsgidalqslaKKDLQ--Q----AYACVAniNILDLSAIGleaWEAGKQAYNNKVDASE 610  Cryptosporidi...
XP_004993240  473 apgeavtg---------------sldaqdvqaVKDVD--S----AYNMMKdiDALDLSDQGarlWSTRLQAYHDRIALVE 531  Salpingoeca r...
EGD73488      463 giepd---------------------adednaLAEVE--N----AYDEMRsvDVLDLEEEGqraWDRACESYEARVNQVE 515  Salpingoeca r...
XP_022522624 3725 --------------------------------VDVMK--E--FTLYITTKmaNPAYSPEVS---AKTAIVDFTVTVKGLE 3765 Mexican tetra
6F1T_EE       562 TRITARLRDQLGTAKNANEmFRIFSRFN-Al--fVRPHIRGAIREYQTQLIQRVKDDIESLHDKFKVqypQSqAC---KM 635 
A0D7F8        528 ATITTNLRDSLGSA-SSAK--EMFRILAkFnklfSRPRIKGAIQEYQSQLLKTVHKDIQSLQNKFKE---TYqkSqnsRL 601  Paramecium te...
XP_004039886  369 IKITSQLRDKLGQAKENAN--EMFRIFNkFnklfVRPHIRGAIQEYQSDLLEKVQKKITQLREKFVK---KYnnTenaVI 443  Ichthyophthir...
ESS29321      588 SQITARLRDRLGAS-TTSG--EMFRVFSqFnalfFRPRVRGAIQEYQTTLLQQVKMDLRKLQESFLD---GHqrVetlTM 661  Toxoplasma go...
Q7RPJ1        600 SQITFKLRDKLGGA-KTSN--EMFNVFSkFnplfFRPKIKGAIQEYQNSLIQIVVEDIKKLQMIYIN---GYvkSsseKV 673  Plasmodium yo...
EEA07374      609 TLLIKQLREQLNNA-SNTL--DMFHILGrYnvlfFRPRIRNAVEEYQNILLEKVEADFKLLQTRYQN---PYqsNaasQF 682  Cryptosporidi...
Q5CSZ3        611 TLLIKQLREQLSGC-GNTL--EMFRILGrYnplfFRPRIRSAVEEYQSILLEKVQSDFQLLQLRYQN---PYqrSaasQF 684  Cryptosporidi...
XP_004993240  532 ARVSSKLRDQLGAA-RSAN--DMFRILSrYetlvNRKNIKSEIKSHSGQLLSRVLTDIDKLHHKFAV---EFeaTtnaRL 605  Salpingoeca r...
EGD73488      516 DTIIKHLCHELDHA-AKSS--DMFRIFRhYyallDRPRIRNAVRSYQKQLMSNVKDDIIELHKKFKM---QYhnSnnsHM 589  Salpingoeca r...
XP_022522624 3766 DQLLGRVILTEKQELESER-VKMLAEVT-------------SNKRKMQELEDNLLYRLTSTQGSLVE---DEsL-----I 3823 Mexican tetra
6F1T_EE       636 shvrD-LPPVSGSIIWAKQIDRQLTAYMKRVEDvLgkgwenhvegQKLKQDGDSFRMKLNTQEIFDDWARKVQqrnlGV- 713 
A0D7F8        602 as-aRdIPLTSGFVIWSKQLQIRLQKYMQKVEQiLgpqwaedtdgKKCKEMGETFERILDSGPALEDWKQEINh---HNk 677  Paramecium te...
XP_004039886  444 cq-vRdVPNIAGSVIWANQMVKKLNKYMEKVADvLgdkwtehhqgQKCKEDCEEFKKFLNIQPIVDEWNNEILn---LNq 519  Ichthyophthir...
ESS29321      662 ae-aRdMAPVAGSIVWAKQLERRLEGLIKRIEDvLghgweqhvegQKLRQDIDAFRQRLNQNQLFENWLQVVK----DEk 736  Toxoplasma go...
Q7RPJ1        674 st-iRdIPLVAGSIIWCKQIEKKLEDSFKKIENvLgrgweqhaegKNLKQNIDNFKNLLNQNKTFEKWLKSIK----NGd 748  Plasmodium yo...
EEA07374      683 sy-lRdIPNVGGTLIWSHLLQDRIQNIYQKLESiFgsnwefeaqgHKVKSDGDQITSKIHPSKIVDYWLQRRKd---DKv 758  Cryptosporidi...
Q5CSZ3        685 sc-lRdIPNIGGMLVWSHLLQERIQSIYFKLEDiFgpnwefesqgHKVKTDGDHITSKIHPNQIVDFWLQQRKd---DKl 760  Cryptosporidi...
XP_004993240  606 sk-aRdVPPVSAKIVWIKQFEHKLDLYLSRVDNvLgigwdklpegKKLRRSAEELRAKLDHDAVFNHW--Q-E----QAa 677  Salpingoeca r...
EGD73488      590 sa-aRdIPPTSGQIIWMAQIERQLDDYLERVGHvLgpnwmkhvdgRELKERGETFKEKLRQANPYDLWLQEIEt---QDi 665  Salpingoeca r...
XP_022522624 3824 ev-lR-VTKSTAEEVR-EKLLVAAETEIKINEa-Ree-------yRPVATRGSILYFLIVEMSLVNVMYQT-------S- 3884 Mexican tetra
6F1T_EE       714 ----SGR---IFTIesTRVRgrtgnvlKLkVNFLPEIITLSKEVRNLKWLGf--rV-PLAIVNKAHQANQLYPFAISLIE 783 
A0D7F8        678 avsqNEK---LFEVv-tRRrgl-----eirVNYEKKLSQLFKEVRNLSNMKt--kV-PYSISHIANDAKASYPFALSLQE 745  Paramecium te...
XP_004039886  520 ataeNER---IFKIv-qKRkle------lvVNYDERQINLFKDIRILELQKs--rH-STSLKYVANKAKMIYPYAMSIQE 586  Ichthyophthir...
ESS29321      737 rldtGDR---IFLIrvlggr-----gfeldVNFDLDLLTLFKEVRLLNTLQy--rI-PYSVKVMADEAKVLYPFVTTLRV 805  Toxoplasma go...
Q7RPJ1        749 kfdiYEK---IIKIkkigin-----nyeilANYDQQLFNLFKEVRYLQSINl--rV-PYSIKVKADETKLIYPYALGLEK 817  Plasmodium yo...
EEA07374      759 tydlNKP---VFGLq-kNYnatis-nsilvTTIDPNILSLFKDLRIIQSYSy--rV-PYSVKVLSDELKLLYPYITRLNS 830  Cryptosporidi...
Q5CSZ3        761 tydlNKP---VLGLm-kSGnlstt-sfilaSTIDSGILSLFKDLRIIQSYAy--rV-PYSVKVLADELKLLYPYISHLNS 832  Cryptosporidi...
XP_004993240  678 klehSSSttkALGVv-qNKagkl----elvVDVPRVAIEANNESRNLKFLGh--rP-RVGLARKFMFARTSYSFCMSLDG 749  Salpingoeca r...
EGD73488      666 t--fKNT---IFDIe-lFRgektr--lemfVNFHERLITMAKEVRIMGWLKnvprV-PKLAVVKAKKANMLYPYVISLKN 736  Salpingoeca r...
XP_022522624 3885 ----LRQ---FLGIfdSSIE-------KS----PKSQITSKRLINIMDFLTy--eVfRYTVRGLYEDHKFLFTLLLTLKI 3944 Mexican tetra
6F1T_EE       784 SVRTYERTCEKVEErnTIS--------------------LLVAGLKKEVQALIAEGI-ALVWESY-KLDPY 832 
A0D7F8        746 SLHTYIQITSQL-----NAks-----------------aKLVAALRKEVQLQIGQGFn-YLWTHKtQLQPY 793  Paramecium tetraurelia
XP_004039886  587 SIQSYNQIVSQV-----DDkm-----------------kKLVTSHKLKIHQTIKKGMv-INWNSNnFIANY 634  Ichthyophthirius multi...
ESS29321      806 VLRTYTEACRLI-----EGspsppgtggmrtksgesvaaLLVASYQREAQQRLAEGLs-LRWDSD-RLESY 869  Toxoplasma gondii VEG
Q7RPJ1        818 TLRVYMKICLYL-----ENegkdip--------fngtisMLVASAHNSVQEKIKEGIn-LHWDSD-ILETY 873  Plasmodium yoelii yoelii
EEA07374      831 LCMNWMRISTFL-----EMepgk-------------risPLLTPYRNDVYNVIQDGLt-LKWSSD-HLDAF 881  Cryptosporidium muris ...
Q5CSZ3        833 LCINWMRIATQL-----EVepgk-------------risPLLTPFRQEVYNIIQEGIs-LSWSSD-RLEGF 883  Cryptosporidium parvum
XP_004993240  750 SVRTYKHTLAKL-----ADapk---------------lkPLVAKYHDRIHRLLHDHId-LTWGDH-RVERF 798  Salpingoeca rosetta
EGD73488      737 SIKTYSIAMNQL-----DDrph---------------ltPLVARWYNRVHDQIAYGMd-LTWESP--LEAY 784  Salpingoeca rosetta
XP_022522624 3945 DLQAKNISHPEFQA--LIK--------------------GGASLDLNSVEPKPRRWIlDMTWLNL-VHLSS 3992 Mexican tetra
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap