Conserved Protein Domain Family
RTX_C

?
pfam08339: RTX_C 
RTX C-terminal domain
This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli and Actinobacillus pleuropneumoniae. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes. This region is found in association with the RTX N-terminal domain (pfam02382) and multiple hemolysin-type calcium-binding repeats (pfam00353).
Statistics
?
PSSM-Id: 400576
View PSSM: pfam08339
Aligned: 6 rows
Threshold Bit Score: 126.53
Threshold Setting Gi: 81556790
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
WP_036365015 784 AFADANLSELTIERTQEGILIKL----------NDNSGSINVSNWYI----ASKLVNYHGHKTDNKIEHLI-GKDGTYIT 848  Moraxella bovo...
WP_003788410 813 AFADADLSELTIERTAQGIMIKR----------NDGSGSINMAEWYK----TLSRPNYHGNATDDKIEQII-GKNGDYIT 877  Kingella kingae
EGK07793     813 AFADADLSELTIERTAQGIMIKR----------NDGSGSINMAEWYK----TLSRPNYHGNATDDKIEQII-GKNGDYIT 877  Kingella kinga...
Q46716       854 HLSDISFDDIAFKRVGNDLIMNKaingvlsfneSNDVNGITFKNWFA----------KDASGADNHLVEVItDKDGREI- 922  Escherichia co...
WP_025216434 807 SFSDSNLKDLTFEKVKYNLVIT-----------NTKKETVTIQNWFReadlAKEVRNYQATK-DEKIEEII-GRNGERIT 873  Mannheimia var...
WP_015433040 809 SFSDSNLKDLTFEKVNHHLVIT-----------NTKQEKVTIQNWFReaefAKTIQNYVATR-DDKIEEII-GQNGERIT 875  Bibersteinia t...
WP_036365015 849 SEQIDSLL--ENKQVGeKITSQQLQELANkNKSQEISVSDIASSLNKLIGSMALFGT--------------ENPVSSNTL 912  Moraxella bovo...
WP_003788410 878 SEQIDKLL--KDKQTG-TITSAQLQQLAQeNKSKSIDSGNLASTLNKLIESMASFGS--------------RGATASNYL 940  Kingella kingae
EGK07793     878 SEQIDKLL--KDKQTG-TITSAQLQQLAQeNKSKSIDSGNLASTLNKLIESMASFGS--------------RGATASNYL 940  Kingella kinga...
Q46716       923 --KVDKIPhnNNERSG-YIKASNIA-----SEKNMVNITSVANDINKIISSVSGFDSgderlaslynlslhQNNTHSTTL 994  Escherichia co...
WP_025216434 874 SSQVDDLI---AKGNG-KIDQNELTKVVD-NYELLKRSRNVTNSLDKLISSVSSFTS--------------SNDSRNVLV 934  Mannheimia var...
WP_015433040 876 SKQVDELI---EKGNG-KIAQSELTKVVD-NYQLLKYSRDASNSLDKLISSASAFTS--------------SNDSRNVLA 936  Bibersteinia t...
WP_036365015 913 QPTT 916  Moraxella bovoculi
WP_003788410 941 QPAH 944  Kingella kingae
EGK07793     941 QPAH 944  Kingella kingae ATCC 23330
Q46716       995 TTTV 998  Escherichia coli O157:H7
WP_025216434 935 NPTS 938  Mannheimia varigena
WP_015433040 937 SPTS 940  Bibersteinia trehalosi
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap