4BT8


Conserved Protein Domain Family
P4Ha_N

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pfam08336: P4Ha_N 
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.
Statistics
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PSSM-Id: 400573
View PSSM: pfam08336
Aligned: 173 rows
Threshold Bit Score: 38.7561
Threshold Setting Gi: 939214732
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4BT8_A                9 IGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLts--tATKDPEG-----FVGHPVNAFKLMKRLNTEW-S 80 
WGS:AAQB:GK10713-PB  90 TITRSTIYDYDKEGNVPVNFRTSNSVFLLNNASYLVDILRQRv----ADMTHLN-----VFKNSSDDLQVMNYGLGGYyR 160 Drosophi...
1_pfamImport          2 LRHLKEAYQKEADLLNYLKEYNSEFQRHLDKIKKDIRKIKSEhe--iAEKDVDN-----YFRNPFNSFHIIKRIFVDY-K 73 
WGS:AANI:GJ22755-PA  29 EDGVQSLLDVEEILVKQFELYLDKAEKERDSIMRFLDHVNHLh--------KDMdepeeYFGNPINAFTTISRFANNWkH 100 Drosophi...
WGS:AAQB:GK13123-PA  26 TSELEALVDVEVRLVQQIEFYLQKAEEQQENIKRFLENVEKVpd---dPYYIED-----YFENPINAFITIKRLVHDWrY 97  Drosophi...
WGS:AAPP:GF23328-PA  28 TSELERLLDVEAFIVEKFEEYLDRAQQEQDNIKRFLDQVEKLq--------PDHddlegYFGNPLNAFTTIRRLVYDWkY 99  Drosophi...
XP_001628326         14 MDQLQRLSTVEKNLHETLDLYIMQERKRLEDLKGIYAAKKEEl----KKRERDD-----EVYHPLDVFRVINRVSSEW-S 83  starlet ...
XP_016036988         24 ISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDEQq--------NDRgdleeYFGNPINAFITIKRLVHDWkF 95  Drosophi...
XP_016662304         25 qiMLTKLYDVQNDHFNVLDNYANLETKRLEELKNYVAAVYEWrdnikTKKQ--------FLHDHMDVFKVMTQMLQHY-F 95  pea aphid
XP_016659455         31 LSSIYKLFDLEVEHIMATEAYIKNEYKRLEDIKMFIEQRKKQn----EKELAES-----YTESSINAFKTILRIKNDWet 101 pea aphid
4BT8_A               81 EL-ENLVLkdmsdgfisnltiqrqyfp----ndedqvgaakallrlqdtyNLDTDTISKGNLP 138
WGS:AAQB:GK10713-PB 161 YH-FDFFGkde------------------------------------spnKLLGDRIITVLIY 186 Drosophila willistoni
1_pfamImport         74 EF-HQEISenkifenfkheankiiiteey-ptdedllssamsiariqetyNIQTSELASGLIA 134
WGS:AANI:GJ22755-PA 101 EIfDVVLAhesytefkqrltneldrheleeptsedlvgatrdlldmqeseGRATSELANEVIf 163 Drosophila virilis
WGS:AAQB:GK13123-PA  98 NVfEPVFDqsdlvaykenltkqlespdfknptkddllgatrglwrlqetyKLPTSQLANGILM 160 Drosophila willistoni
WGS:AAPP:GF23328-PA 100 NVfEPIFNttnledykssisgglktidfkgpneedlkgatrgllrlqniyQLPTAQLANGVLA 162 Drosophila ananassae
XP_001628326         84 TV-EKLVRfnphksefiqeirnyhasfp---sdadfdgtraamlrlqkvyNISSQSISSGVIP 142 starlet sea anemone
XP_016036988         96 NVfDPLFDssnfetyknnlsdslekinfkgptqedlhgatrallrlqniyQLNTDHLASGVLl 158 Drosophila simulans
XP_016662304         96 QI-DDLIKnkksleafkdidehkdlsg-----ehivllahralrrlqlfyAIPASDMSAGRFN 152 pea aphid
XP_016659455        102 lknktaqttpigefkdks------------vtydnivsglkairrlqiiyELDTQDISNWNIg 152 pea aphid
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