3ELI,1X53,1XFS,2L9P,1Z94


Conserved Protein Domain Family
AHSA1

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pfam08327: AHSA1 
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Activator of Hsp90 ATPase homolog 1-like protein
This family includes eukaryotic, prokaryotic and archaeal proteins that bear similarity to a C-terminal region of human activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1/p38). This protein is known to interact with the middle domain of Hsp90, and stimulate its ATPase activity. It is probably a general upregulator of Hsp90 function, particularly contributing to its efficiency in conditions of increased stress. p38 is also known to interact with the cytoplasmic domain of the VSV G protein, and may thus be involved in protein transport. It has also been reported as being underexpressed in Down's syndrome. This region is found repeated in two members of this family.
Statistics
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PSSM-Id: 400566
View PSSM: pfam08327
Aligned: 82 rows
Threshold Bit Score: 60.4035
Threshold Setting Gi: 81375095
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ELI_A  11 AVAPEALFAWVSDGAKLLQwWgp--egLHVPADQHDLdftRL--GPWFSV--XVNGEGQRYKVSGQVTHVKPPQSVGFT- 83  Ruegeria pomeroyi
O53773 112 PLDPTSTFALITQPDRLRR-W-------MAVAARIEL---RT--GGAYRW-----TVTPGHSAAGTVIDVDPGKRVVFT- 172 Mycobacterium tubercu...
Q67N43   4 KAPQEVVWWAWTRAERITQ-W-------FAPAATIDP---RP--GGAFELffNPADRSRDCTAGCTFTAVEPMTRLAFT- 69  Symbiobacterium therm...
Q63JA1  15 NAPRSRVWRALTNADEFGA-W------FRVDLAGQTFeagRCveG-RITY-----PGYEHLVLRMRIERIEPEHRFSYH- 80  Burkholderia pseudoma...
Q89BJ6  56 AAPIDQVWRAYTTPADIVK-WnaasddWHTTKATVDL---RE--GGIFSSrmEAKDGSMGFDFAGTYTKIVEHKLIEYA- 128 Bradyrhizobium japonicum
Q97CZ9  19 NAPIDMVWEAWTEPEHIKS-WnhasddWHTTEAKNDL---RV--GGRFVSkmEAKDGSFGFDFGGTYNKVRLYEFISYIm 92  Clostridium acetobuty...
Q89QH5  14 TTSPEKVYRAFLEADALAK-Wlpp-ngFTCTVHHFEP---KV--GGTFKMsfRNFTTGNSHAFGGEYLELVPGERLRYT- 85  Bradyrhizobium japonicum
Q6FE81  11 NAPPSRVYRAFLEPDALVK-Wiap-ngFTAKVHSFEA---KE--GGQYQMsfTNFSTGSSHSFGGTYIKLIPNHLIRYN- 82  Acinetobacter baylyi
Q8PEA7  44 RASPERVYRAFLDAAALSK-Wlpp-hgFTNTVEHLDA---RV--GGTFRMafTQFGSGQRHAFGGTYRELVPNALLRYD- 115 Xanthomonas campestri...
1Z94_B  12 SAPPERVYRAFLDPLALAK-Wlpp-egFVCKVLEHDA---RV--GGAYKXefLAFASGQKHAFGGRYLELVPGERIRYT- 83  Chromobacterium viola...
3ELI_A  84 WGWHddDDRRg------aESHVXFIVEPCAKGARLILDH---RELGDDEXSLR----HEEGWTSSLRKLAAELA 144 Ruegeria pomeroyi
O53773 173 WGWEdhGDPPp------gGSTVTITLTPVDGGTEVRLVH---DGLTAQQAAR-----HAKGWNHFLDRLVVAGQ 232 Mycobacterium tuberculosis
Q67N43  70 WKGPdlFAAVmnh--pdrLTAVTVTMEPVEGGTRVTVVH---AGWGEGDGWAEarrwHAAAWRQVLDSLKGALE 138 Symbiobacterium thermophilum
Q63JA1  81 WHPA--AIDPavdyaqetPTLVVFELADVAGGTLLTVVEsgfDKLPIERRAEAfr-mNDGGWGEQMTNIAAHVD 151 Burkholderia pseudomallei
Q89BJ6 129 FGDR----------------KAEVEFVPGSNGIVVRVVF---DSEPTHSVEQ-----QQGGWQAILDNFARYVE 178 Bradyrhizobium japonicum
Q97CZ9  93 DDDR----------------SVEITFKPEKDKTYIVESF---EAEKSNPIDL-----QQKGWQAILDNFKKYVE 142 Clostridium acetobutylicum
Q89QH5  86 -DKF--DDPNlp-----gEIQVTVLLKKVSVGTEVDITQ---AGIPDLIPPEA----CYLGWQESLRNLAKLVE 144 Bradyrhizobium japonicum
Q6FE81  83 -DHF--DHPAls-----gQIEVTIEIQPVSVGAEVYITQ---SGIPYAIPVEA----CYLGWQQSLHLLGLLVN 141 Acinetobacter baylyi
Q8PEA7 116 -DVF--DDPSlp-----gTLLTTVRLLPLPCGTDLHVVQ---EGIPEQIPLHA----CYLGWQESLTLLALLVE 174 Xanthomonas campestris pv. ...
1Z94_B  84 -DRF--DDAGlp-----gDXITTITLAPLSCGADLSIVQ---EGIPDAIPPEN----CYLGWQQSLKQLAALVE 142 Chromobacterium violaceum A...
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