5CSK,5I6I,6G2D


Conserved Protein Domain Family
ACC_central

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pfam08326: ACC_central 
Acetyl-CoA carboxylase, central region
The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (pfam01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyzes the rate-limiting step in this process.
Statistics
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PSSM-Id: 400565
View PSSM: pfam08326
Aligned: 111 rows
Threshold Bit Score: 502.094
Threshold Setting Gi: 217403172
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5CSK_A        747 TLDDPSKVKHALPFEGML--PDFGSP------V-IEG-------TKPAYKFKSLVSTLENILKGYDn-----QVIMNASL 805 
XP_003581375  843 DLDDPSAVKRAEPFDGFF--PEMSLP------IaASC--------QVHKRCAASLNAARMVLAGYE-------HPINKVV 899  stiff brome
AQK42623      839 DLDDPSAVKRAEPFDGMF--PLMDLP------VaASS--------QVHKRYAASLNAARMVLAGYE-------HNINEVV 895  Zea mays
B9FK36        842 DLDDPSAVKRAEPFEDTF--PQMGLP------IaASG--------QVHKLCAASLNACRMILAGYE-------HDIDKVV 898  Japanese rice
ERM94222      763 DLDDPSAVRKAEPFHGCF--PPLGPP------TaVAG--------KVHQRCAASINAARMILAGYE-------HNIDEVV 819  Amborella tri...
XP_009148001  840 DLADPSTVRKAEPFHGGF--PRLGLP------TeISA--------KVHQRCAATLDAARMILAGYE-------HQVDEVV 896  field mustard
XP_002997355  766 ELDDPSCVKKSDVFMGKL--PSA---------EnTNGs-----sTKSVHKMRKSLAVLKCVLQGYYapedltQ----KAL 825  Phytophthora ...
EEC43127      756 ALDNPENVATVSVFEGDLqvTGWGQSiarnttSsSNGstsnngtRNAHLVLRKAVQALHRATDGYIl----lPETIDAAM 831  Phaeodactylum...
XP_009107907  741 DLDDPSAVRKAEPFHGGF--PRLGLP------TaISG--------KVHQRCAATLNAARMVLAGYE-------HKVDEVV 797  field mustard
XP_009380189  746 DLDDPSAVRRAEPFHGSF--PKLGPP------TaVSG--------KVHQRCAASLSSARMILAGYE-------HNINEVV 802  wild Malaysia...
5CSK_A        806 QQLIEVLRNPKLPYSEWKLHISALHSRLPAKLDEQME---ELVARSLRR--G--AVFPARQLSKLIDMAVKNPEynpDK- 877 
XP_003581375  900 QDLVCCLDTPELPFLQWEELMSVLATRLPRDLKSELEgkySDY--KLTVdhGknKDFPTKTLRGIIEENLACCSe-kEKa 976  stiff brome
AQK42623      896 QDLVCCLDNPELPFLQWDELMSVLATRLPRNLKSELEdkyKEY--KLNFyhGknKDFPSKLLRDIVEENLAYGSe-kEKa 972  Zea mays
B9FK36        899 PELVYCLDTPELPFLQWEELMSVLATRLPRNLKSELEgkyEEY--KVKFdsGiiNDFPANMLRVIIEENLACGSe-kEKa 975  Japanese rice
ERM94222      820 QDLLNSLDSPELPFLQWQECMAVLATRLPKELRNALDsifKEY--EVLLstQknVEFPAKMLKGVMEAYLLSCTe-kERv 896  Amborella tri...
XP_009148001  897 QDLVSCLDSPELPFLQWQECFAVLATRLPKDLRIMLEskyMEY--ECISrnSltADFPAKLLKGILEAHVASCDe-nERg 973  field mustard
XP_002997355  826 VDLFQVLNEPLLPVEEIREAMSSLAGRIPLDVFAKITdkiQTFKKAVAEdpTaaHEFNAAEIADILDEHKKTLDtdrKRs 905  Phytophthora ...
EEC43127      832 ADLMQAVADPFLPVLEIREQLSVLSSRLPATLLRSIStmvREY------------ENPA------LASHVSSISdtsARa 893  Phaeodactylum...
XP_009107907  798 QDLLNCLDSPELPFLQWQECFAVLATRLPKDLRMMLEskyREF--ESISrnSltADFPAKLLKGILEAHLLSCDe-kDRg 874  field mustard
XP_009380189  803 QDLLHCLDSPELPFLQWQESMSVLATRLPKDLRNELDtryREH--EAIStfQknLDFPAKLLKGVLEGHLSSCTe-kEKa 879  wild Malaysia...
5CSK_A        878 LLGAVVEPLADIAHKYSNGLEA------HEHSIFVHFLEEYYEVEKLFNgpnvREENIILKLRDENPK-DLDKVALTVLS 950 
XP_003581375  977 TNERLVEPLMSLLKSYEGGREN------HAHFIVKSLFEEYLSVEELFSdd--iQSDVIERLRLQHSK-DLQKVVDIVLS 1047 stiff brome
AQK42623      973 TNERLVEPLMNLLKSYEGGRES------HAHFVVKSLFEEYLTVEELFSdg--iQSDVIETLRHQHSK-DLQKVVDIVLS 1043 Zea mays
B9FK36        976 TNERLVEPLMSLLKSYEGGRES------HAHFVVKSLFEEYLYVEELFSdg--iQSDVIERLRLQHSK-DLQKVVDIVLS 1046 Japanese rice
ERM94222      897 TQERLVEPLMSLAKSYEGGRES------HAHVIVQSLFEEYLSVEEIFNdn--iQADVIERLRLQYKK-DLLKVVDIVLS 967  Amborella tri...
XP_009148001  974 ALERLIEPLMSLIKSYEGGRES------HACVIVRSLFEEYLSIEELFNdn--mLPDVIERMRHEYTKvDRSKIVDIVLS 1045 field mustard
XP_002997355  906 DFEASVVALRDITTKYKHGLAS------GEEAVLTELINEYFTVETVYAns-hNIEDVVMALRQQNSA-DLNKVFSIARS 977  Phytophthora ...
EEC43127      894 TFEALITPLREAVLPYNRGKASgvpgaqRAVDSFLIALEKWTANERWFCdg-kSYADAVEELRQGHKN-DPGYILSVCRA 971  Phaeodactylum...
XP_009107907  875 ALERLIEPLMSLAKSYEGGRES------HARVIVHSLFEEYLSVEELFNdn--mLADVIERMRQQYKK-DLLKIVDIVLS 945  field mustard
XP_009380189  880 TQERLVEPLMSLVKSYEGGRES------HARVIVRSLFEEYLTVEELFSds--iQADVIERLRLQHKK-DLLKIVDIVLS 950  wild Malaysia...
5CSK_A        951 HSKVSAKNNLILAILKHYQplck-------lssKVSAIFSTPLQHIVELe-SKATAKVALQAREILIQGALPSVKERTEQ 1022
XP_003581375 1048 HQGVRNKTKLILTLMEKLVypn---------psA----YRDQLIRFSSLn-HKRYYKLALKASELLEQTKLGELRTSIAR 1113 stiff brome
AQK42623     1044 HQGVRNKAKLVTALMEKLVypn---------pgA----YRDLLVRFSSLn-HKRYYKLALKASELLEQTKLSELCSSIAR 1109 Zea mays
B9FK36       1047 HQSVRNKTKLILKLMESLVypn---------paA----YRDQLIRFSSLn-HKAYYKLALKASELLEQTKLSELRARIAR 1112 Japanese rice
ERM94222      968 HQGVRSKNKLILRLMEALVypn---------paA----YRDKLIRFSALn-HTSYSELTLKASQLLEHTKLSDLRTSIAR 1033 Amborella tri...
XP_009148001 1046 HQGLKSKNKLVLGLMEHFVnan---------paV----YRDKLIRFLKLn-HTNYSEVVLKASQLLKQRKLSELRSSI-- 1109 field mustard
XP_002997355  978 HKALEAKNKLLLQLLAQMArgtavtpr----ksmksasFVPLLEKLATFk-EKQYSLVALEARQLLIDNKMPSYRDRLSQ 1052 Phytophthora ...
EEC43127      972 HEQLQTTSKLVTSIMTAIGvgskinptggagtesVILHAESAISEIGSMgsNDLYREVALKARKLLMQESLPSLELRKGR 1051 Phaeodactylum...
XP_009107907  946 HQGIKNKNKLVLRLMEQLVypn---------paA----YRDKLIRFSTLn-HTNYSELALKASQLLEQTKLSELRSNIAR 1011 field mustard
XP_009380189  951 HQGVRSKNKLILRLMEAMVypn---------paA----YHDLLIRFSALn-HTTYSELALKASQLLEQTKLSELRTSIAR 1016 wild Malaysia...
5CSK_A       1023 IEHILK-----SSVVKVAYGSSNpkrSEPDLNILKDLIDSNYVVFDVLLQFLTHQDPV-VTAAAAQVYIRRAYRAYTI-G 1095
XP_003581375 1114 SLSEL------EMFTEERVGLSLqerTLAIDESMGDLVTAPLPVEDALISLFDCTDQT-LQQRVIETYISRLYQPHLVkD 1186 stiff brome
AQK42623     1110 SLSDL----------------GMhkgEMTIKDSMEDLVSAPLPVEDALISLFDYSDPT-VQQKVIVTYISRLYQPHLVkD 1172 Zea mays
B9FK36       1113 SLSEL------EMFTEESKGLSMhkrEIAIKESMEDLVTAPLPVEDALISLFDCSDTT-VQQRVIETYIARLYQPHLVkD 1185 Japanese rice
ERM94222     1034 SLSEL------EMFTEEGERLNTprrKNAIEERMEDLVSAPLAVEDALIALFDHIDHT-LQRRVVETYVRRLYQPYLEkG 1106 Amborella tri...
XP_009148001 1110 -LSEL------EMFAEDGESMDTpkrKCA----MEDLVSAPLAVEDALVGLFDHSDRT-LQRLVVETYIRRLYQPYVVkE 1177 field mustard
XP_002997355 1053 VEKVLK-----DYIANGS--------STNLAEACANLLDQSQPLFDLLISLLDHEDQK-IRELALELYALRVYRSYLI-E 1117 Phytophthora ...
EEC43127     1052 FVAAAShvataD--------------GANLSSTVTDLLADQTPMVDLLFPLLKSSSSGlESVGLAEIFVRRMYRSFSMkD 1117 Phaeodactylum...
XP_009107907 1012 SLSEL------EMFTEDGENMDTpkrKSAINERMEDLVSASLAVEDALVGLFDHSDHT-LQRRVVETYIRRLYQPYVVkE 1084 field mustard
XP_009380189 1017 SLSEL------EMFTEEGERLSTprrKSAINERMEDLVGTPLAVEDALIAFFDHSDPT-LQRRVVETYIRRLYQPYLIkE 1089 wild Malaysia...
5CSK_A       1096 DIRVHEGVTVP-IVEWKFQlpSAAFSTFP------------TVKSKMGMNRAV---SVSDLSYV--AN-SQSSP------ 1150
XP_003581375 1187 SVQLKYKE-SGvIGIWEFA--EEHANIRNg------------QKPTLPE------------------------------- 1220 stiff brome
AQK42623     1173 SIQMKFKE-SGaIVFWEFS--EGHVDTRNg------------QGAILGG------------------------------- 1206 Zea mays
B9FK36       1186 SIKMKWIE-SGvIALWEFP--EGHFDARNg-------------GAVLGD------------------------------- 1218 Japanese rice
ERM94222     1107 SVRMQWHR-SAlIALWKFS--EEHAAMRDgsgyp---msdePKIEKHVE------------------------------- 1149 Amborella tri...
XP_009148001 1178 SVRMQWHQ-YGfIASWEFL--DDHMERKNtegsddqetsekVFVEKRRK------------------------------- 1223 field mustard
XP_002997355 1118 SMETMSFN-DIfAKTFQFK-----SPVVDalavg--vapaeSYDDLASLLRRNssaSSLDLGEQnsEEsSEEQEpaekpl 1189 Phytophthora ...
EEC43127     1118 IIRDGERRS------FKFA-----FMEKQ---------------AEGAVSNLStvaSLMDLKRVvsSGsLMETNdepses 1171 Phaeodactylum...
XP_009107907 1085 SIRMQWHR-SGlIASWEFL--EEHMERKNiglddq-etpekGLVEKRSE------------------------------- 1129 field mustard
XP_009380189 1090 SVRMQWHR-SGlIASWEFS--QEHIEKKNksqdp---snclSSVEKHCE------------------------------- 1132 wild Malaysia...
5CSK_A       1151 --------------LREGILMAVDHLDDVDE--ILSQSLEVI-----P-RHQSSSNgpapdrsgssASL-SNVANVCVAS 1207
XP_003581375 1221 --------------KRWGAMVILKSLESVST--AIGVALKDAsh--------------------ysSSE-GNIMHIALLG 1263 stiff brome
AQK42623     1207 --------------KRWGAMVVLRSLESAST--AIMAALKDSvq--------------------ynNSE-VNTMHIVLLN 1249 Zea mays
B9FK36       1219 --------------KRWGAMVIVKSLESLSM--AIRFALKETsh--------------------ytSSE-GNMMHIALLG 1261 Japanese rice
ERM94222     1150 --------------KRWGVMVIIKSLQFLPT--AINVALKETahssgSnASDEPSRsgs----sasASH-GNMLHVALVG 1208 Amborella tri...
XP_009148001 1224 --------------KKKGFMVIIKSLEFLPNi-ITAAALTET-----N-HIDYGESags--------plsGNIMHIAvl- 1273 field mustard
XP_002997355 1190 akpvesyqkispsfERHGAIARLANLETFQK--SFTDVMSLF----------PLAKktl----svrKDPlVNVLHVILV- 1252 Phytophthora ...
EEC43127     1172 ggvipvkqgipadtLRIGVCMVVDNVSDVADadTIQNVSSQFvan-------------------sgSDP-VNVLYFIVL- 1230 Phaeodactylum...
XP_009107907 1130 --------------RKWGAMVIIKSLQFLPS--IISAALTET-----N--HNEHVSaga--------plsGNMMHIAIVG 1178 field mustard
XP_009380189 1133 --------------KRWGAMVIIKSLQLLPA--AINTALKETtqcmnSdIDHEIIPngl----pgcSGK-GNMLHVALVG 1191 wild Malaysia...
5CSK_A       1208 TEGFEs---EEE----ILVRLREILDLNKQE-----LINASIRRITFMF--GF-K--------DGSYPKYYTFNGp---- 1260
XP_003581375 1264 DDNQInkseDSGdndqAQDRIDKLSVILKQNivtadLRAAGVKVVSCIV--QRdG---------ARMPMRRTFLLsdekl 1332 stiff brome
AQK42623     1250 AETESn--iSGTsddqAQHRMEKLTKILKDSsvasdLQAAGLKVISCIV--QRdA---------GRMPMRHTFLWfdekn 1316 Zea mays
B9FK36       1262 ADNKMhiiqESGd---dADRIAKLPLILKDNvt--dLHASGVKTISFIV--QRdE---------ARMTMRRTFLWsdekl 1325 Japanese rice
ERM94222     1209 MNNQMsllqDSGdedqAQERINKLAKILKEEtigssLCSAGVDVVSCII--QRdE---------GRAPMRHSFHWlsdkl 1277 Amborella tri...
XP_009148001 1274 --------dSENeedqAQERVEK---ILKEEevsssLCSAGVGVVSCII--ERdE---------GRTPMRHSFHWsmekq 1331 field mustard
XP_002997355 1253 ----DehseESK----LLEQAEAYLKSVDVD-----LRAHNIRRVTFSVrpQNiEdisvhnadMALYPNIYTFPGr---m 1316 Phytophthora ...
EEC43127     1231 --NSDigldEAShq-eIAKKCELILQGSHAL-----LEQAGVRGVTFVMnqhy------defeEYRAPAMFTFRFp---- 1292 Phaeodactylum...
XP_009107907 1179 INNQMsllqDSGdedqAQERVDKLAKILKEEevissLCSAGVGVISCII--QRdE---------GRTPMRHSFHWsmekh 1247 field mustard
XP_009380189 1192 INNQMstlqDSGdedqAQERINKLAKILKENtlssdLQDADVRVISCII--QRdE---------GRVPMRHSFHWsaekm 1260 wild Malaysia...
5CSK_A       1261 NYNENETIRHIEPALAFQLELGR--LS-NFNIKPIFTDNR---NIHVYEAVSKTSP--------LDK--RFFTRGIIRTG 1324
XP_003581375 1333 CFEEEPILRHVEPPLSALLELDKlkVKgYNEMKYTPSRDR---QWHIYTLRNTENP---------KMlhRVFFRTLVRQP 1400 stiff brome
AQK42623     1317 CYEEEHILRHVEPPLSALLELGKlkVKgYNEMKYTPSRDR---QWHIYTLRNTENP---------KMlhRVFFRTIVRQP 1384 Zea mays
B9FK36       1326 SYEEEPILRHVEPPLSALLELDKlkVKgYNEMKYTPSRDR---QWHIYTLRNTENP---------KMlhRVFFRTLVRQP 1393 Japanese rice
ERM94222     1278 HYEEEPLLRHLEPPLSTFLELDK--LKgYTDIQYTPSRDR---QWHMYTVVDKPLTy------------RMFLRTLVRQP 1340 Amborella tri...
XP_009148001 1332 YYAEEPMLRHLEPPLSIYLELDK--LRgYENIQYTPTRDR---QWHLYTVTDNKPV--------PVR--RMFLRSLVRQG 1396 field mustard
XP_002997355 1317 NYSEDKILRHMEAPLAYKLELRR--LQ-NYSVTPLASENK---NVHLYLAKMKDSDah----iiTDRfqRIFVRAVVRQL 1386 Phytophthora ...
EEC43127     1293 aYKEIALYRGIDPVRAPQLDLNR--VAaNFDIRGLGSHNSatgQAHLYEAVPKKAAlasdhkasKAA--RVFVRSLGFVT 1368 Phaeodactylum...
XP_009107907 1248 YYAEEPLMRHLEPPLSIYLELDK--LKgYSNIQYTPSRDR---QWHLYTVTDKSMP---------IK--RMFLRSLVRQA 1311 field mustard
XP_009380189 1261 YYEEEPLLRHLEPPLSTFLELEK--LKgYRNLQYTSSRDR---QWHLYTTLDSKAV---------IR--RMFLRTLLRQP 1324 wild Malaysia...
5CSK_A       1325 HIRDDIsiq-------------eyLTSEA-NRLMSDILDNLEV--------TDTSNSDLNHIFINFIA--VFDI-SP--- 1376
XP_003581375 1401 TAGNKFtsgrtsdieaghaeeslsFTSSSiLRSLMTAIEELEL---------HAIRTGHSHMYLCILR--EQKLlDLvpv 1469 stiff brome
AQK42623     1385 NAGNKFtsaqvsdtglgcpeeslsFTSNSiLRSLMTAIEELEL---------HAIRTGHSHMFLCILK--EQKLlDLvpf 1453 Zea mays
B9FK36       1394 SVSNKFssgqigdmevgsaeeplsFTSTSiLRSLMTAIEELEL---------HAIRTGHSHMYLHVLK--EQKLlDLvpv 1462 Japanese rice
ERM94222     1341 NSQDSEmavdga-------kmampFTATSiLRSLNAALEELELhg----hnA-NVKSDHVHLYLCILR--EQQLlDLlpn 1406 Amborella tri...
XP_009148001 1397 QDNQ---------------------LSQTlVRSLMDAMEELELna----hkEDGMKPDHAHMFLCLLP--EQQInDLvpy 1449 field mustard
XP_002997355 1387 DHDGSGsrs-------------qyDAYPGpERSLVDALNALEVnlsnplvkKSSLPTKNNHVYLNILP--QAIV-DP--- 1447 Phytophthora ...
EEC43127     1369 D-----------------------MNQTSfDRILVDTLNAFDL--------CSVKSRMDNHVFINVASdfEKTVlDP--- 1414 Phaeodactylum...
XP_009107907 1312 TMNDGFmlqqgqdkqlsqtlfsmpFTSRCvLRSLMDAMEELELna----hnA-AMKPDHAHMFLCILR--EQQIdDLvpy 1384 field mustard
XP_009380189 1325 STINGFassqvldteisraqpslsFTSISiLRSLMAALEELELhv----hnT-TTRSDHSHMYICILR--EQQLhDLlpp 1397 wild Malaysia...
5CSK_A       1377 ----------------EDVEAAFGGFLERFGKRLLRLRVSSAEIRIIIKdpQTGAPV-PLRALINNVSGYVIKTEMYTEV 1439
XP_003581375 1470 sgstvvdvgqdeatacSLLKEMALKIHELVGARMHHLSVCQWEVKLKLD--SDGPASgTWRVVTTNVTSHTCTVDIYREA 1547 stiff brome
AQK42623     1454 sgstivdvgqdeatacSLLRSMALKIHELVGARMHHLSVCQWEVKLKLD--CDGPASgTWRVVTTNVTSHTCTIDIYREV 1531 Zea mays
B9FK36       1463 sgntvldvgqdeataySLLKEMAMKIHELVGARMHHLSVCQWEVKLKLD--CDGPASgTWRIVTTNVTSHTCTVDIYREM 1540 Japanese rice
ERM94222     1407 fsdvei-kgeeekaiyMILEQMARSIHETVGVKMYRLAVCEWEVKLRIG--YVGLASgAWRVVITNLTGHTCTIHVYREL 1483 Amborella tri...
XP_009148001 1450 privevnaeveettmeMILEETVREIHKSAGVRMHRLGVCEWEVRLCLS--SSGLASgAWRVVVTNVTGRTCTVHIYREA 1527 field mustard
XP_002997355 1448 ----------------QYLEGVIRILAYRYAERLEQLGVSTVELKIIARfnSEAPAI-PVRLVAENPTGYVVRVQAYVEA 1510 Phytophthora ...
EEC43127     1415 ----------------VTVEHVVAGILKKHGERITTMGIVEVEIRIVCRlsSESHPI-ALRLVSSNPTGYVHVMSTYVEA 1477 Phaeodactylum...
XP_009107907 1385 prrvevnaedeettieVILEEAAREIHRSVGVRMHRLGVCEWEVRLWLV--SSGLASgAWRVVVANVTGRTCTVNIYREV 1462 field mustard
XP_009380189 1398 srimaldscqdetticLILKEMALKIHELVGVRMHRLAVCEWEVKLWLN--SDGLA--AWRIVVTNVTGHTCTVHIYREV 1473 wild Malaysia...
5CSK_A       1440 KNAK-GEWVFKSLG-KPGSMH 1458
XP_003581375 1548 EDTEaQKLVYHSaTsLSAPLH 1568 stiff brome
AQK42623     1532 EDTEsQKLLYHSaTsSAGPMH 1552 Zea mays
B9FK36       1541 EDKEsRKLVYHPaTpAAGPLH 1561 Japanese rice
ERM94222     1484 EDTNrHEVVYHSkLsTSAPVh 1504 Amborella trichopoda
XP_009148001 1528 EATGsNSLIYQS-ItNKGPLH 1547 field mustard
XP_002997355 1511 AGHD--EPIFTSI---GDETH 1526 Phytophthora infestans T30-4
EEC43127     1478 ADDSsDERKFKLI----GNTK 1494 Phaeodactylum tricornutum CCAP 1055/1
XP_009107907 1463 ETSGrNSLIYHS-ItKKGPLH 1482 field mustard
XP_009380189 1474 ENINsHEMVYHSiTpANGPLH 1494 wild Malaysian banana
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