Conserved Protein Domain Family
tRNA_lig_CPD

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pfam08302: tRNA_lig_CPD 
Fungal tRNA ligase phosphodiesterase domain
This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.
Statistics
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PSSM-Id: 400548
Aligned: 75 rows
Threshold Bit Score: 142.757
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003170706 553 SRENLETIVDYFYANYPKLMkrEKPDAAELDAAIKEAMDGYT-VD-IKHDLNFK---SKSQPQKQQNqqqqqqqqnqknq 627
XP_004179612 563 SLKNAKTVAQNLHLEFPILMp-TIPTDLEFKEAFDKAL-SYK-PT-VRKNVGNN---NKRNGKDNSYns----------v 625
XP_001643312 561 SIKNVKTILNELNKEYPILIp-KVPSQSEIDIAFKRSL-EYK-PT-VTKIVGSG---GRNNGNGGNN------------- 620
CCE91732     570 SLHNAKTVLHELNKEYPVLVp-EVPSSDRIEQAFNQSL-NYK-PK-ITKIVRGI---GGSESKKNL-------------- 628
Q6FJW3       562 SLINAKRILNNLHDKYPVLVp-TVPTDEEIRAAFEKSL-EYK-PT-TVKIINEK---GSRRNKNKDKk------------ 622 [Candida] glabrata
P09880       566 SLTNAKQILNEIHKAYPILVp-EIPKDDEIETAFRRSL-DYK-PT-VRKIVGKG---NNNQQK----------------- 621 Saccharomyces c...
XP_003673897 562 SLMNVKTILKRLHDVYPILIp-EIPSEESINIAFQKSL-QYK-PKmKERKVTNNetvSGTPKK----------------- 621
XP_003954723 564 SLINSMTIINELHEKYPILIp-KMPTTMELEDAFKQSI-EFKiPS-KTKEMNMN---NKLTKK----------------- 620
CCK68629     564 SLINTKIILENLHREYPILVp-EIPDENAIKSSFDLSL-EHKiPI-----KPGSstpNTKEKKNKPAk------------ 624
Q10313       547 SLENARRIVNYFKKNIPELIp-NDPSDDDYAAALNYAVNEYV-PT-YRKTFGND---SKKIKNKITAe-----------g 609 Schizosaccharom...
XP_003170706 628 KPQTLDQLVKKIEYFNISV-PAGPVNAILASIFD-ASPs--pDYAHLY--RLLTNSRRIQPSFHVTLIH---RASSA--- 695
XP_004179612 626 NKKSVRKPNVHAVYYSATIaEQNELINTVVNLISeSDI----NLSKKTslLEYFDLNKYQREFHITLSHv--SSAKNgtq 699
XP_001643312 621 --EEIRQKKINPVYYSATImDLQLIRSEILKSLEdSDLg---EEEKML--IKNTVENKLQNKLHITLAHv--GSSKRgtp 691
CCE91732     629 -----------PTFFSAHInNRLEIIEEISNLVQnAKLd--dAAKSGI--KKLFQENKFQSEFHITLSHi--SQRKKgte 691
Q6FJW3       623 HTSAPTMKKLKPVYFFAELrDPTKLLRCIKAFIEeNRSs--iDNDSYIhiDRLFQDKKYQEKLHVTLIHl--MQGKKgte 698 [Candida] glabrata
P09880       622 -----TPKLIKPTYISAKIeNYDEIIELVKRCIAsDA-----ELTEKF--KHLLASGKVQKELHITLGHv----MSSrek 685 Saccharomyces c...
XP_003673897 622 --------KVRPAYFSVNIkDGTPIKELISNVIEkPSNis-eDAQTIL--KNLLQNDNFQESFHITLAHv--MQGKRgdp 688
XP_003954723 621 ---------INPAYFSANLdNKDKLIVAIMQLMEdDSSnnhgINFEPL--EKLLDENLFQPGFHITLSHv--AQGKRgdp 687
CCK68629     625 KDPLLKPKKLKPVYFSANV-SVDLVKSAIDTLIMqNLGkiaeEGNQYL--TSLFAEDKFQKAFHVTLSHraqSSSNSgde 701
Q10313       610 ITGSSTCFKKAPRYFGVLL-DRKTVESSLVQVLTiANL----QWQEAF--SRYT----LQDSFHITMIH---ESQKP--- 672 Schizosaccharom...
XP_003170706 696 DNPQIWHTYTDLYKATIAQQQQQQnTSSSAaslpgsatvtgtptpsLGAASVRLETLVWDKRIMAIVARILSGpaasgat 775
XP_004179612 700 FQKDMWSRYQQHYKPILKKLKDTPiKENVDpnasni-----lsidvNDTLKFKLDKLYFDDKIMTATVKVDSEciydpkg 774
XP_001643312 692 EQQAIWKNYSNRYIPYL--------KTVFKstevpt----steiitEDSVKFSIRKLCMDSKIFTAIVDINELgvltseg 759
CCE91732     692 LQRATWQNLIHRYQNLI----------STIkiqkee----rhclstKDVVKFSIRKLCWDEKIVGILVDLPEEhlfdvdg 757
Q6FJW3       699 TQQQLWDDYLRSFDEYL---------TVNPetfdkn----cdriktKYSIKVTVQSLYWDSKIATLTVKpelvever--- 762 [Candida] glabrata
P09880       686 EAKKLWKSYCNRYTDQITEYNNNR-IENAQgsgnnq----ntqvktTDKLNFRLEKLCWDEKIIAIVVELSKDkdgciid 760 Saccharomyces c...
XP_003673897 689 AEQELWKAYLKHYKKIL-----------KSyndkei----pklietNDFVRFQPKMICWDDKIVSIVIKFPNDecvsden 753
XP_003954723 688 RDKILWKEYLKEFDPQL---------TEISardnyq----etlfktDYRVKFKLDKLCWDDKIVAVMVKFEDTncvtdkd 754
CCK68629     702 RGKRNWERYTKHYEPII------KmSESTNnsqent----alpirtGDIVSMRLSKLIWDDKIVTIIVDLLENtdnsiav 771
Q10313       673 VNSRIWEQYLQHMHDKNTTK--------------------------MGNISFRITHLVWDDRVICFRVTMNen------- 719 Schizosaccharom...
XP_003170706 776 tgvataalpisgeahsdrreeeerqgerelaptW--PCANEIAHVTIGTANASVKPKESNDLLK--RWLTMGA-GEESGI 850
XP_004179612 775 ------------------------------klipglGCSNTVPHITVCILLEGTKPFYSNTLCDs---vLANG-V-VDGI 819
XP_001643312 760 ------------------------------nnisnlRCSNNYSHITLGILKEGTKPFYSNELCEk---vEAGS-A-GEDV 804
CCE91732     758 ------------------------------eavpriNFRNEVSHITVGILETGTPPFYTNELCRk---vLSSD-K-KRDY 802
Q6FJW3       763 -----------------------------dgslntlACCNDIPHITLGILEEGIKPVYSNELLKmmNQ-NDKE-SRPANS 811 [Candida] glabrata
P09880       761 e---------------------------nnekikglCCQNKIPHITLCKLESGVKAVYSNVLCEk---vESAE-V-DENI 808 Saccharomyces c...
XP_003673897 754 -----------------------------gllvtklKCANKIPHITVARLQDNVKAVYSNTICKd--vVENRD---ATNI 799
XP_003954723 755 -----------------------------nvtitglECSNKFPHITIGRLNSDIKASYSNSLCEr---iMKDD-ADGESS 801
CCK68629     772 rs-------------------------aerevinglNCTNLIPHITIGILQDGVKAYYSNELCNk---iASGG-N-TSGC 821
Q10313       720 -------------------------------svWygKTCNPQLHITLGTSSSDVKAFESNFLLKklRWQGDEVdSTDGNV 768 Schizosaccharom...
XP_003170706 851 WEAKIPSVKVVEGFVGVVM 869
XP_004179612 820 YCIKFNDPKEYNAAVRINL 838
XP_001643312 805 KSWKISRPNILEAKVTINL 823
CCE91732     803 HVLEFEYPKRFEANVRITf 821
Q6FJW3       812 FCLELAGLEVQIADVYIHL 830 [Candida] glabrata
P09880       809 KVVKLDNSKEFVGSVYLNf 827 Saccharomyces cerevisiae S288C
XP_003673897 800 NHVELVDSPSLTGNVCINL 818
XP_003954723 802 YYLNFNDSEEFVADVCINL 820
CCK68629     822 FELNFVDSKVFDAEVYINL 840
Q10313       769 RYLTVLPKIIIEGMLEPVy 787 Schizosaccharomyces pombe 972h-
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