Conserved Protein Domain Family
tRNA_lig_CPD

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pfam08302: tRNA_lig_CPD 
Fungal tRNA ligase phosphodiesterase domain
This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.
Statistics
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PSSM-Id: 400548
View PSSM: pfam08302
Aligned: 75 rows
Threshold Bit Score: 142.757
Threshold Setting Gi: 758973671
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003170706 553 SRENLETIVDYFYANYPKLMkrEKPDAAELDAAIKEAMDGYT-VD-IKHDLNFK---SKSQPQKQQNqqqqqqqqnqknq 627 Nannizzia gypse...
XP_004179612 563 SLKNAKTVAQNLHLEFPILMp-TIPTDLEFKEAFDKAL-SYK-PT-VRKNVGNN---NKRNGKDNSYns----------v 625 Tetrapisispora ...
XP_001643312 561 SIKNVKTILNELNKEYPILIp-KVPSQSEIDIAFKRSL-EYK-PT-VTKIVGSG---GRNNGNGGNN------------- 620 Vanderwaltozyma...
CCE91732     570 SLHNAKTVLHELNKEYPVLVp-EVPSSDRIEQAFNQSL-NYK-PK-ITKIVRGI---GGSESKKNL-------------- 628 Torulaspora del...
Q6FJW3       562 SLINAKRILNNLHDKYPVLVp-TVPTDEEIRAAFEKSL-EYK-PT-TVKIINEK---GSRRNKNKDKk------------ 622 [Candida] glabrata
P09880       566 SLTNAKQILNEIHKAYPILVp-EIPKDDEIETAFRRSL-DYK-PT-VRKIVGKG---NNNQQK----------------- 621 Saccharomyces c...
XP_003673897 562 SLMNVKTILKRLHDVYPILIp-EIPSEESINIAFQKSL-QYK-PKmKERKVTNNetvSGTPKK----------------- 621 Naumovozyma cas...
XP_003954723 564 SLINSMTIINELHEKYPILIp-KMPTTMELEDAFKQSI-EFKiPS-KTKEMNMN---NKLTKK----------------- 620 Kazachstania af...
CCK68629     564 SLINTKIILENLHREYPILVp-EIPDENAIKSSFDLSL-EHKiPI-----KPGSstpNTKEKKNKPAk------------ 624 Kazachstania na...
Q10313       547 SLENARRIVNYFKKNIPELIp-NDPSDDDYAAALNYAVNEYV-PT-YRKTFGND---SKKIKNKITAe-----------g 609 Schizosaccharom...
XP_003170706 628 KPQTLDQLVKKIEYFNISV-PAGPVNAILASIFD-ASPs--pDYAHLY--RLLTNSRRIQPSFHVTLIH---RASSA--- 695 Nannizzia gypse...
XP_004179612 626 NKKSVRKPNVHAVYYSATIaEQNELINTVVNLISeSDI----NLSKKTslLEYFDLNKYQREFHITLSHv--SSAKNgtq 699 Tetrapisispora ...
XP_001643312 621 --EEIRQKKINPVYYSATImDLQLIRSEILKSLEdSDLg---EEEKML--IKNTVENKLQNKLHITLAHv--GSSKRgtp 691 Vanderwaltozyma...
CCE91732     629 -----------PTFFSAHInNRLEIIEEISNLVQnAKLd--dAAKSGI--KKLFQENKFQSEFHITLSHi--SQRKKgte 691 Torulaspora del...
Q6FJW3       623 HTSAPTMKKLKPVYFFAELrDPTKLLRCIKAFIEeNRSs--iDNDSYIhiDRLFQDKKYQEKLHVTLIHl--MQGKKgte 698 [Candida] glabrata
P09880       622 -----TPKLIKPTYISAKIeNYDEIIELVKRCIAsDA-----ELTEKF--KHLLASGKVQKELHITLGHv----MSSrek 685 Saccharomyces c...
XP_003673897 622 --------KVRPAYFSVNIkDGTPIKELISNVIEkPSNis-eDAQTIL--KNLLQNDNFQESFHITLAHv--MQGKRgdp 688 Naumovozyma cas...
XP_003954723 621 ---------INPAYFSANLdNKDKLIVAIMQLMEdDSSnnhgINFEPL--EKLLDENLFQPGFHITLSHv--AQGKRgdp 687 Kazachstania af...
CCK68629     625 KDPLLKPKKLKPVYFSANV-SVDLVKSAIDTLIMqNLGkiaeEGNQYL--TSLFAEDKFQKAFHVTLSHraqSSSNSgde 701 Kazachstania na...
Q10313       610 ITGSSTCFKKAPRYFGVLL-DRKTVESSLVQVLTiANL----QWQEAF--SRYT----LQDSFHITMIH---ESQKP--- 672 Schizosaccharom...
XP_003170706 696 DNPQIWHTYTDLYKATIAQQQQQQnTSSSAaslpgsatvtgtptpsLGAASVRLETLVWDKRIMAIVARILSGpaasgat 775 Nannizzia gypse...
XP_004179612 700 FQKDMWSRYQQHYKPILKKLKDTPiKENVDpnasni-----lsidvNDTLKFKLDKLYFDDKIMTATVKVDSEciydpkg 774 Tetrapisispora ...
XP_001643312 692 EQQAIWKNYSNRYIPYL--------KTVFKstevpt----steiitEDSVKFSIRKLCMDSKIFTAIVDINELgvltseg 759 Vanderwaltozyma...
CCE91732     692 LQRATWQNLIHRYQNLI----------STIkiqkee----rhclstKDVVKFSIRKLCWDEKIVGILVDLPEEhlfdvdg 757 Torulaspora del...
Q6FJW3       699 TQQQLWDDYLRSFDEYL---------TVNPetfdkn----cdriktKYSIKVTVQSLYWDSKIATLTVKpelvever--- 762 [Candida] glabrata
P09880       686 EAKKLWKSYCNRYTDQITEYNNNR-IENAQgsgnnq----ntqvktTDKLNFRLEKLCWDEKIIAIVVELSKDkdgciid 760 Saccharomyces c...
XP_003673897 689 AEQELWKAYLKHYKKIL-----------KSyndkei----pklietNDFVRFQPKMICWDDKIVSIVIKFPNDecvsden 753 Naumovozyma cas...
XP_003954723 688 RDKILWKEYLKEFDPQL---------TEISardnyq----etlfktDYRVKFKLDKLCWDDKIVAVMVKFEDTncvtdkd 754 Kazachstania af...
CCK68629     702 RGKRNWERYTKHYEPII------KmSESTNnsqent----alpirtGDIVSMRLSKLIWDDKIVTIIVDLLENtdnsiav 771 Kazachstania na...
Q10313       673 VNSRIWEQYLQHMHDKNTTK--------------------------MGNISFRITHLVWDDRVICFRVTMNen------- 719 Schizosaccharom...
XP_003170706 776 tgvataalpisgeahsdrreeeerqgerelaptW--PCANEIAHVTIGTANASVKPKESNDLLK--RWLTMGA-GEESGI 850 Nannizzia gypse...
XP_004179612 775 ------------------------------klipglGCSNTVPHITVCILLEGTKPFYSNTLCDs---vLANG-V-VDGI 819 Tetrapisispora ...
XP_001643312 760 ------------------------------nnisnlRCSNNYSHITLGILKEGTKPFYSNELCEk---vEAGS-A-GEDV 804 Vanderwaltozyma...
CCE91732     758 ------------------------------eavpriNFRNEVSHITVGILETGTPPFYTNELCRk---vLSSD-K-KRDY 802 Torulaspora del...
Q6FJW3       763 -----------------------------dgslntlACCNDIPHITLGILEEGIKPVYSNELLKmmNQ-NDKE-SRPANS 811 [Candida] glabrata
P09880       761 e---------------------------nnekikglCCQNKIPHITLCKLESGVKAVYSNVLCEk---vESAE-V-DENI 808 Saccharomyces c...
XP_003673897 754 -----------------------------gllvtklKCANKIPHITVARLQDNVKAVYSNTICKd--vVENRD---ATNI 799 Naumovozyma cas...
XP_003954723 755 -----------------------------nvtitglECSNKFPHITIGRLNSDIKASYSNSLCEr---iMKDD-ADGESS 801 Kazachstania af...
CCK68629     772 rs-------------------------aerevinglNCTNLIPHITIGILQDGVKAYYSNELCNk---iASGG-N-TSGC 821 Kazachstania na...
Q10313       720 -------------------------------svWygKTCNPQLHITLGTSSSDVKAFESNFLLKklRWQGDEVdSTDGNV 768 Schizosaccharom...
XP_003170706 851 WEAKIPSVKVVEGFVGVVM 869 Nannizzia gypsea CBS 118893
XP_004179612 820 YCIKFNDPKEYNAAVRINL 838 Tetrapisispora blattae CBS 6284
XP_001643312 805 KSWKISRPNILEAKVTINL 823 Vanderwaltozyma polyspora DSM 70294
CCE91732     803 HVLEFEYPKRFEANVRITf 821 Torulaspora delbrueckii
Q6FJW3       812 FCLELAGLEVQIADVYIHL 830 [Candida] glabrata
P09880       809 KVVKLDNSKEFVGSVYLNf 827 Saccharomyces cerevisiae S288C
XP_003673897 800 NHVELVDSPSLTGNVCINL 818 Naumovozyma castellii CBS 4309
XP_003954723 802 YYLNFNDSEEFVADVCINL 820 Kazachstania africana CBS 2517
CCK68629     822 FELNFVDSKVFDAEVYINL 840 Kazachstania naganishii CBS 8797
Q10313       769 RYLTVLPKIIIEGMLEPVy 787 Schizosaccharomyces pombe 972h-
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