3FQM


Conserved Protein Domain Family
HCV_NS5a_1b

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pfam08301: HCV_NS5a_1b 
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Hepatitis C virus non-structural 5a domain 1b
The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR. This region corresponds to the 1b domain.
Statistics
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PSSM-Id: 149382
View PSSM: pfam08301
Aligned: 21 rows
Threshold Bit Score: 132.871
Threshold Setting Gi: 81921784
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FQM_A     66 GPCTPSPAPnYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVkCPCQVPaPEFF--TEVDGVRLHRYAPACKPLLREEV 143 
Q69422   1963 GSARPDPTD-WTSLVVNYGVRDYCKYEKLGDHIFVTAVSSPNV-CFTQVP-PTLRaaVAVDGVQVQCYLGEPKTPWTTSA 2039 Hepatitis GB virus B
O41914    180 GETSPLLAS-DMPKVVPFGTSGWAEVVVTPTHVVVRRTSCYKL-LRQQILsAAVAepYYVDGIPVSWEADARAPAMVYGP 257  GB virus C
O56074   2056 GDAEPEVPA--GPALYQIGVAEWVQLVRKDKTLVVGASSVYHL-HIDELRrAIRGppMFVGGVGVSWEAPLQQPPLVYRA 2132 Pegivirus A
O41892   2037 GGATPVVPP-RGPKTYQLGCADWIEALVVSGTVTVTASSAYDL-TAAEVRrAVKAspCFAGDLPVSWEAPICRPAMVYRG 2114 Pegivirus A
O56073   2045 GAAEPAPPP-RGLKTYQFGYKDWVEALVMEGTMTIHATSCYET-TAAELRrAARTrpCFSQGVACSWEAPMSPPAMVYRT 2122 Pegivirus A
Q58V89   2073 GPSVPAPSPnYTRALWRVAAEEYVEILRVGDSHYVVGVTADNVkCPCQVPaPEFF--TEIDGVRIHRYAPKCKPLLRDEV 2150 Hepacivirus C
O92529   2073 SPSVPVPAPnYKRALWRVSAEEYVEVERHGDRHYVVGVTADGLkCPCQVPgPEFF--TEVDGVRIHRYAPPCKPLLRDEV 2150 Hepatitis C virus...
Q1KL34   2073 GPSTPRPAPnYQRALWRVSAEDYVEVRRLGDYHYVVGVTAEGLkCPCQVPaPEFF--TEVDGVRIHRYAPPCKPLLRDEV 2150 Hepatitis C virus...
ABI36963 2068 GPSVPIPSPnYRKALWRVAAEEYVEVVRHGDNHYIVAATSDNLkCPCQVPsPEFF--TEVDGIRLHRYAPACRPLLRDEI 2145 Hepatitis C virus...
3FQM_A    144 TfLVGLNQYLVGSQLPcePEPDV 166 
Q69422   2040 C-CYGPDGKGKTVKLP--FRVDG 2059 Hepatitis GB virus B
O41914    258 GqSVTIDG--ERYTLPhqLRMRN 278  GB virus C
O56074   2133 GqSVRFDD--VRYSLPhtLALPP 2153 Pegivirus A
O41892   2115 GqTIQLDG--VRRTLPcgLPLGA 2135 Pegivirus A
O56073   2123 GqTITIDG--VRKMLPctLVLGA 2143 Pegivirus A
Q58V89   2151 SfSVGLNTYVVGSQLPcdPEPDV 2173 Hepacivirus C
O92529   2151 SfSVGLLEFVVGSQLPcePEPDV 2173 Hepatitis C virus (isolate Th580)
Q1KL34   2151 TfSVGLSNYAIGSQLPcePEPDV 2173 Hepatitis C virus subtype 6a
ABI36963 2146 TySVGLSTYIIGSQLPcePEPDV 2168 Hepatitis C virus subtype 6f
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